Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review

Milad Iranshahy, Mohammad Yahya Hanafi-Bojd, Seyed Hadi Aghili, Mehrdad Iranshahi, Seyed Mohammad Nabavi, Satar Saberi, Rosanna Filosa, Iman Farzam Nezhad and Maede Hasanpour

RSC Adv., 2023, 13, 22250
DOI: 10.1039/D3RA02772D

pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia

Hasan Keshavarz, Alireza Khavandi, Somaye Alamolhoda and M. Reza Naimi-Jamal

RSC Adv., 2020, 10, 39008
DOI: 10.1039/D0RA06916G

ROS-responsive mesoporous silica nanoparticles for MR imaging-guided photodynamically maneuvered chemotherapy

Vijayakameswara Rao N, Hwa Seung Han, Hansang Lee, Van Quy Nguyen, Sangmin Jeon, Dae-Woong Jung, Jeongjin Lee, Gi-Ra Yi and Jae Hyung Park

Nanoscale, 2018, 10, 9616
DOI: 10.1039/C8NR00888D

Amino-functionalized mesoporous silica nanospheres (MSN-NH2) as sorbent for extraction and concentration of synthetic dyes from foodstuffs prior to HPLC analysis

Peige Qin, Yixin Yang, Wenqi Li, Jing Zhang, Qian Zhou and Minghua Lu

Anal. Methods, 2019, 11, 105
DOI: 10.1039/C8AY02215A

Curcumin-loaded metal oxide aerogels: supercritical drying and stability

Wael Hamd, Digambara Patra and Houssam El-Rassy

RSC Adv., 2021, 11, 34479
DOI: 10.1039/D1RA06693E

Tailor-made spider-eggcase-silk spheres for efficient lysosomal drug delivery

Jianming Chen, Jinlian Hu, Peijun Zuo, Xiaoqian Su, Zhigao Liu and Mo Yang

RSC Adv., 2018, 8, 9394
DOI: 10.1039/C8RA00232K

Co-delivery of doxorubicin and curcumin to breast cancer cells by a targeted delivery system based on Ni/Ta core-shell metal-organic framework coated with folic acid-activated chitosan nanoparticles

Samaneh-sadat Jalaladdiny, Arastoo Badoei-dalfard, Zahra Karami and Ghasem Sargazi

J IRAN CHEM SOC, 2022, 19, 4287
DOI: 10.1007/s13738-022-02604-w

High-Performance Spirulina–Bismuth Biohybrids for Enhanced Computed Tomography Imaging

Maryam Hosseini, Zahed Ahmadi, Mehdi Khoobi, Sadegh Dehghani and Amirhosein Kefayat

ACS Sustainable Chem. Eng., 2020, 8, 13085
DOI: 10.1021/acssuschemeng.0c04877

pH-Responsive Release of Anesthetic Lidocaine Derivative QX-OH from Mesoporous Silica Nanoparticles Mediated by Ester Bonds

Ken Takahashi, Yasuhiro Nakagawa, Yu Sato, Ryo Wakita, Shigeru Maeda and Toshiyuki Ikoma

SSRN Journal, 2022
DOI: 10.2139/ssrn.4183237

Facile post modification synthesis of copper-doped mesoporous bioactive glass with high antibacterial performance to fight bone infection

Maryam Hosseini, Negar Hassani Besheli, Dongmei Deng, Caroline Lievens, Yi Zuo, Sander C.G. Leeuwenburgh and Fang Yang

Biomaterials Advances, 2023, 144, 213198
DOI: 10.1016/j.bioadv.2022.213198

Facile development, characterization, and evaluation of novel bicalutamide loaded pH-sensitive mesoporous silica nanoparticles for enhanced prostate cancer therapy

Seema Saroj and Sadhana J. Rajput

Drug Development and Industrial Pharmacy, 2019, 45, 532
DOI: 10.1080/03639045.2018.1562463

Nanodiamond-Protein hybrid Nanoparticles: LHRH receptor targeted and co-delivery of doxorubicin and dasatinib for triple negative breast cancer therapy

Behdad Delavari, Bahareh Bigdeli, Sepideh Khazeni and Pegah Varamini

International Journal of Pharmaceutics, 2025, 675, 125544
DOI: 10.1016/j.ijpharm.2025.125544

Investigating the effect of rAzurin loaded mesoporous silica nanoparticles enwrapped with chitosan-folic acid on breast tumor regression in BALB/C mice

Hajar Mohammadi Barzelighi, Bita Bakhshi, Bahram Daraei and Arezoo Mirzaei

International Journal of Biological Macromolecules, 2025, 300, 139245
DOI: 10.1016/j.ijbiomac.2024.139245

Gadolinium (III) oxide nanoparticles coated with folic acid-functionalized poly(β-cyclodextrin-co-pentetic acid) as a biocompatible targeted nano-contrast agent for cancer diagnostic: in vitro and in vivo studies

Tohid Mortezazadeh, Elham Gholibegloo, Nader Riyahi Alam, Sadegh Dehghani, Soheila Haghgoo, Hossein Ghanaati and Mehdi Khoobi

Magn Reson Mater Phy, 2019, 32, 487
DOI: 10.1007/s10334-019-00738-2

Galactosylated chitosan-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery

Wei Liu, Yongchao Zhu, Fan Wang, Xue Li, Xiaojing Liu, Jingjing Pang and Weisan Pan

R. Soc. open sci., 2018, 5, 181027
DOI: 10.1098/rsos.181027

pH-responsive release of anesthetic lidocaine derivative QX-OH from mesoporous silica nanoparticles mediated by ester bonds

Ken Takahashi, Yasuhiro Nakagawa, Yu Sato, Ryo Wakita, Maeda Shigeru and Toshiyuki Ikoma

Journal of Drug Delivery Science and Technology, 2022, 78, 103977
DOI: 10.1016/j.jddst.2022.103977

Cross-Linked Poly(acrylic acid) Hydrogel Loaded with Zinc Oxide Nanoparticles and Egg White Proteins for Antimicrobial Application

Mehdi khoobi, Morvarid Moghimi, Ghodratollah Hashemi Motlagh, Farzaneh Sorouri and Esmaeil Haririan

J Inorg Organomet Polym, 2020, 30, 5234
DOI: 10.1007/s10904-020-01619-1

Folic Acid Targeted Selenium–Curcumin Nanoparticles to Enhance Apoptosis in Breast Cancer Cells

Fateme Davarani Asl, Pooria Mohammadi Arvejeh, Mehdi Rezaee, Javad Saffari‐Chaleshtori, Fatemeh Deris, Atefeh Satari, Samira Asgharzadeh and Pegah Khosravian

Chemistry & Biodiversity, 2025
DOI: 10.1002/cbdv.202500183

Evaluation of targeted curcumin (CUR) loaded PLGA nanoparticles for in vitro photodynamic therapy on human glioblastoma cell line

Zahra Jamali, Mehdi Khoobi, Sedigheh Marjaneh Hejazi, Neda Eivazi, Saeideh Abdolahpour, Fatemeh Imanparast, Hemen Moradi-Sardareh and Maliheh Paknejad

Photodiagnosis and Photodynamic Therapy, 2018, 23, 190
DOI: 10.1016/j.pdpdt.2018.06.026

pH-sensitive chitosan-PEG-decorated hollow mesoporous silica nanoparticles could be an effective treatment for acute myeloid leukemia (AML)

G. Ultav, H. Tonbul, E. Tavukcuoglu, S. C. Ozturk, S. Akbas, A. Sahin, G. Esendagli and Y. Capan

J Nanopart Res, 2022, 24
DOI: 10.1007/s11051-022-05404-8

An electrochemical biosensor based on DNAzyme and TB-loading mesoporous silica nanoparticles for detection of TdT in serum

Minqiao Feng, Chengyan Yin, Hailiang Qin, Wei Liu, Yunqi Wang, Ruth Antwi-Baah, Yao Rao and Shuxia Xu

Microchemical Journal, 2025, 219, 116073
DOI: 10.1016/j.microc.2025.116073

Green synthesis and optimization of iron oxide nanoparticles as MRI contrast agent

Sathyamoorthy Yuwvaranni, Balaji Amritta, Sathyaraj Weslen Vedakumari and Munusamy Chamundeeswari

Green Materials, 2025, 13, 170
DOI: 10.1680/jgrma.23.00089

Enhancing Cancer Therapy with Silica Nanoparticles: Exploring Curcumin-based Drug Delivery Systems

Niloufar Rahiman, Prashant Kesharwani, Tannaz Jamialahmadi and Amirhossein Sahebkar

Silicon, 2025, 17, 3501
DOI: 10.1007/s12633-025-03435-z

Supercritically dried superparamagnetic mesoporous silica nanoparticles for cancer theranostics

Joana Vaz-Ramos, Rosemeyre Cordeiro, M. Margarida C.A. Castro, Carlos F.G.C. Geraldes, Benilde F.O. Costa, Henrique Faneca and Luísa Durães

Materials Science and Engineering: C, 2020, 115, 111124
DOI: 10.1016/j.msec.2020.111124

Electrophoretic deposition of chitosan/mesoporous bioactive glass nanoparticles/ hexagonal boron nitride composite coating on AZ31 Mg alloy for maxillofacial and biomedical applications

Umaira Najeeb, Khalil Ahmad, Khurram Yaqoob, Haseeb Nawaz, Aqsa Aizaz, Abdul Wadood, Mohamed Abbas, Shaeen Kalathil, Muneer Parayangat, Muhammad Amber Fareed and Muhammad Atiq Ur Rehman

Materials Today Communications, 2026, 50, 114370
DOI: 10.1016/j.mtcomm.2025.114370

Multifunctional MIL-Cur@FC as a theranostic agent for magnetic resonance imaging and targeting drug delivery: in vitro and in vivo study

Sadegh Dehghani, Maryam Hosseini, Soheila Haghgoo, Vahid Changizi, Hamid Akbari Javar, Mehdi Khoobi and Nader Riahi Alam

Journal of Drug Targeting, 2020, 28, 668
DOI: 10.1080/1061186X.2019.1710839

Cholesterol Mediated Stable Vesicles: A Nano Drug Delivery Vehicle for Anti‐cancer Drugs Curcumin and 5‐Fluorourecil

Hiral Ukani, Pratyush, Sugam Kumar, Vinod K Aswal, Azza A. Al‐Ghamdi and Naved I. Malek

ChemistrySelect, 2022, 7
DOI: 10.1002/slct.202201613

Cetuximab-modified silica nanoparticle loaded with ICG for tumor-targeted combinational therapy of breast cancer

Xiaoxue Zhang, Yinyan Li, Minjie Wei, Chang Liu, Tao Yu and Jun Yang

Drug Delivery, 2019, 26, 129
DOI: 10.1080/10717544.2018.1564403

Hybrid nanoarchitecture of gelatin-modified silica-chitosan as an efficient delivery platform and functional role of crosslinking

Zahra Niazi and Mohsen Ashjari

International Journal of Polymeric Materials and Polymeric Biomaterials, 2024, 73, 1291
DOI: 10.1080/00914037.2023.2277237

Poly(lactic-co-glycolic acid)(PLGA)-based nanoparticles modified with chitosan-folic acid to delivery of Artemisia vulgaris L. essential oil to HT-29 cancer cells

Mohadese Alirezaei, Maryam Ghobeh and Ali Es-haghi

Process Biochemistry, 2022, 121, 207
DOI: 10.1016/j.procbio.2022.06.034

Nanoparticles of Antroquinonol-Rich Extract from Solid-State-Cultured Antrodia cinnamomea Improve Reproductive Function in Diabetic Male Rats

Zwe-Ling Kong, Jia-Ling He, Sabri Sudirman, Mao-Tien Kuo, Song Miao, Ke-Liang B Chang and David Tsou

IJN, 2020, Volume 15, 4191
DOI: 10.2147/IJN.S252885

Gold-capped mesoporous silica nanoparticles as an excellent enzyme-responsive nanocarrier for controlled doxorubicin delivery

Parvaneh Eskandari, Bahare Bigdeli, Mohammad Porgham Daryasari, Hadi Baharifar, Behroz Bazri, Mostafa Shourian, Amir Amani, Armin Sadighi, Bahram Goliaei, Mehdi Khoobi and Ali A. Saboury

Journal of Drug Targeting, 2019, 27, 1084
DOI: 10.1080/1061186X.2019.1599379

“Three-in-One” Multifunctional Gatekeeper Gated Mesoporous Silica Nanoparticles for Intracellular pH-Activated Targeted Cancer Therapy

Yajie Zhang, Wei Wang, Yahui Zhang, Mingbo Cheng, Qiang Wu and Zhi Yuan

ACS Appl. Bio Mater., 2018, 1, 572
DOI: 10.1021/acsabm.8b00050

Magnetic ferrite nanoparticles coated with bovine serum albumin and glycine polymers for controlled release of curcumin as a model

Afsoon Aghaei, Hazratuddin Sadiqi, Abdul Ali Khwaja Mohammad, Abdul wali Gulmohammad, Blaž Likozar, Hamed Nosrati, Hossein Danafar and Maryam Shaterian

Journal of Biomaterials Science, Polymer Edition, 2023, 34, 2537
DOI: 10.1080/09205063.2023.2265181

Glutathione conjugated polyethylenimine on the surface of Fe3O4 magnetic nanoparticles as a theranostic agent for targeted and controlled curcumin delivery

Navid Aeineh, Fahimeh Salehi, Mohammad Akrami, Firouzeh Nemati, Masoumeh Alipour, Milad Ghorbani, Banafsheh Nikfar, Fatemeh Salehian, Nader Riyahi Alam, Seyed Esmaeil Sadat Ebrahimi, Alireza Foroumadi, Mehdi Khoobi, Mohammadreza Rouini, Maryam Dibaei, Ismaeil Haririan, Mohammad Reza Ganjali and Saeed Safaei

Journal of Biomaterials Science, Polymer Edition, 2018, 29, 1109
DOI: 10.1080/09205063.2018.1427013

Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery

Bianca Dumontel, Verónica Conejo-Rodríguez, María Vallet-Regí and Miguel Manzano

Pharmaceutics, 2023, 15, 447
DOI: 10.3390/pharmaceutics15020447

A nano drug delivery system loading drugs and chlorin e6 separately to achieve photodynamic-chemo combination therapy

Guohao Yin, Hongli Zhao and Minbo Lan

Nanomedicine, 2025, 20, 559
DOI: 10.1080/17435889.2025.2460960

Formulation and development of smart pH responsive mesoporous silica nanoparticles for breast cancer targeted delivery of anastrozole: In vitro and in vivo characterizations

Dhaval Bhavsar, Jyot Gajjar and Krutika Sawant

Microporous and Mesoporous Materials, 2019, 279, 107
DOI: 10.1016/j.micromeso.2018.12.026

Synthesis of magnetic electroactive nanomotors based on sodium alginate/chitosan and investigation the influence of the external electric field on the mechanism of locomotion

Fariba Mafakheri, Ali Asakereh, Sepideh Khoee and Mojtaba Kamankesh

Sci Rep, 2023, 13
DOI: 10.1038/s41598-023-37463-9

Effects of pore topology and iron oxide core on doxorubicin loading and release from mesoporous silica nanoparticles

Cicily J. Ronhovde, John Baer and Sarah C. Larsen

J Nanopart Res, 2017, 19
DOI: 10.1007/s11051-017-3908-5

Etoposide encased folic acid adorned mesoporous silica nanoparticles as potent nanovehicles for enhanced prostate cancer therapy: synthesis, characterization, cellular uptake and biodistribution

Seema Saroj and Sadhana J. Rajput

Artificial Cells, Nanomedicine, and Biotechnology, 2018, 46, 1115
DOI: 10.1080/21691401.2018.1533843

Targeted cancer treatment using folate-conjugated sponge-like ZIF-8 nanoparticles: a review

Mahsa Akbari Oryani, Shamim Nosrati, Hossein Javid, Ali Mehri, Alireza Hashemzadeh and Mehdi Karimi-Shahri

Naunyn-Schmiedeberg's Arch Pharmacol, 2024, 397, 1377
DOI: 10.1007/s00210-023-02707-y

Alginate coated mesoporous silica nanoparticles as oral delivery carrier of curcumin and quercetin to colon cancer: preparation, optimization, characterization, and anticancer activity

Batoul Alallam, Erazuliana Abdkadir, Alfiah Hayati, Yong Yoke Keong and Vuanghao Lim

Drug Deliv. and Transl. Res., 2025, 15, 3793
DOI: 10.1007/s13346-024-01777-6

A novel method for in situ encapsulation of curcumin in magnetite-silica core-shell nanocomposites: A multifunctional platform for controlled drug delivery and magnetic hyperthermia therapy

Mahsa Asgari, Taghi Miri, Meysam Soleymani and Aboulfazl Barati

Journal of Molecular Liquids, 2021, 324, 114731
DOI: 10.1016/j.molliq.2020.114731

Charge-specific and hesperidin loaded mesoporous silica nanoparticles: Enhanced antimicrobial activity against pathogenic bacteria

Divya Sree H.R., Satyanarayana Swamy Vyshnava and Muralidhara Rao Dowlathabad

Nano-Structures & Nano-Objects, 2025, 41, 101441
DOI: 10.1016/j.nanoso.2025.101441

Tailor-made pH-sensitive polyacrylic acid functionalized mesoporous silica nanoparticles for efficient and controlled delivery of anti-cancer drug Etoposide

Seema Saroj and Sadhana J. Rajput

Drug Development and Industrial Pharmacy, 2018, 44, 1198
DOI: 10.1080/03639045.2018.1438467

Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(N,N-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin

Ecaterina Stela Dragan, Maria Valentina Dinu, Claudiu Augustin Ghiorghita, Maria Marinela Lazar and Florica Doroftei

Molecules, 2021, 26, 6975
DOI: 10.3390/molecules26226975

Facile Synthesis of Amino-functionalized Mesoporous Fe3O4/rGO 3D Nanocomposite by Diamine compounds as Li-ion Battery Anodes

Mahshid Ershadi, Mehran Javanbakht, Daniel Brandell, Sayed Ahmad Mozaffari and Ali Molaei Aghdam

Applied Surface Science, 2022, 601, 154120
DOI: 10.1016/j.apsusc.2022.154120

5-Fluoro uracil mediated transformation of surface-active ionic liquid based micellar nanoaggregates into pH-responsive vesicular nanoaggregates as promising drug delivery vehicle

Ishani Pandya, Siddharth Mishra, Tapas Patel, Nicolas Keppeler, Sugam Kumar, Vinod K. Aswal, Suresh Kumar Kailasa, Omar El Seoud and Naved I. Malek

Journal of Molecular Liquids, 2024, 409, 125443
DOI: 10.1016/j.molliq.2024.125443

Facile Synthesis of Chitosan Capped Mesoporous Silica Nanoparticles: A pH Responsive Smart Delivery Platform for Raloxifene Hydrochloride

Priya V. Shah and Sadhana J. Rajput

AAPS PharmSciTech, 2018, 19, 1344
DOI: 10.1208/s12249-017-0949-0

Folic acid decorated magnetic nanosponge: An efficient nanosystem for targeted curcumin delivery and magnetic resonance imaging

Elham Gholibegloo, Tohid Mortezazadeh, Fatemeh Salehian, Hamid Forootanfar, Loghman Firoozpour, Alireza Foroumadi, Ali Ramazani and Mehdi Khoobi

Journal of Colloid and Interface Science, 2019, 556, 128
DOI: 10.1016/j.jcis.2019.08.046

Development and Evaluation of PLGA Nanoparticles Surfaced Modified with Chitosan-Folic Acid for Improved Delivery of Resveratrol to Prostate Cancer Cells

Hamed Amiri, Hossein Javid, Elham Einafshar, Farideh Ghavidel, Arezoo Rajabian, Seyed Isaac Hashemy and Hossein Hosseini

BioNanoSci., 2024, 14, 988
DOI: 10.1007/s12668-024-01345-9

Optimization and chemical free fabrication of green synthesized iron nanoparticles as potential MRI contrast agent

Yuwvaranni S, Punitha N and Chamundeeswari M

Biotech and App Biochem, 2024, 71, 596
DOI: 10.1002/bab.2561

pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles

Fajar R. Wibowo, Ozi A. Saputra, Witri W. Lestari, Mamoru Koketsu, Rino R. Mukti and Ronny Martien

ACS Omega, 2020, 5, 4261
DOI: 10.1021/acsomega.9b04167

Theranostic Approach for the Protein Corona of Polysaccharide Nanoparticles

Sylvie Skalickova, Pavel Horky, Veronika Mlejnkova, Jiri Skladanka, Bozena Hosnedlova, Branislav Ruttkay‐Nedecky, Carlos Fernandez and Rene Kizek

The Chemical Record, 2021, 21, 17
DOI: 10.1002/tcr.202000042

Folic acid grafted aminated zeolitic imidazolate framework (ZIF-8) as pH responsive drug carrier for targeted delivery of curcumin

Reshmi R., Jiju K.R., Suma S. and Anoop S. Nair

Journal of Drug Delivery Science and Technology, 2023, 79, 104098
DOI: 10.1016/j.jddst.2022.104098

Folic acid-chitosan functionalized polymeric nanocarriers to treat colon cancer

Navya Ajitkumar Bhaskaran, Srinivas Reddy Jitta, Salwa, Lalit Kumar, Pravesh Sharma, Onkar Prakash Kulkarni, Gangadhar Hari, Karthik Gourishetti, Ruchi Verma, Sumit Raosaheb Birangal and K. Vijaya Bhaskar

International Journal of Biological Macromolecules, 2023, 253, 127142
DOI: 10.1016/j.ijbiomac.2023.127142

Transferrin-Conjugated Polymer-Coated Mesoporous Silica Nanoparticles Loaded with Gemcitabine for Killing Pancreatic Cancer Cells

Kusum Saini and Rajdip Bandyopadhyaya

ACS Appl. Nano Mater., 2020, 3, 229
DOI: 10.1021/acsanm.9b01921

Chitosan-coated Zn-metal-organic framework nanocomposites for effective targeted delivery of LNA-antisense miR-224 to colon tumor: in vitro studies

Negin Mokri, Zahra Sepehri, Farnaz Faninam, Sepideh Khaleghi, Negar Motakef Kazemi and Mehrdad Hashemi

Gene Ther, 2022, 29, 680
DOI: 10.1038/s41434-021-00265-7

pH-responsive mesoporous silica nanoparticles functionalized with folic acid and chitosan for targeted epirubicin delivery: In vitro and in vivo efficacy in breast cancer

Nasim Kaveh Farsani, Shamim Afshari, Anita Saremi Poor, Arvin Toutounchi, Zahra Shahbazi, Sara Ramezani, Mohammadreza Tajik, Masoumeh Mirzaei Chegeni, Nastaran Asghari Moghaddam and Hamid Abbasi

International Journal of Biological Macromolecules, 2025, 309, 142558
DOI: 10.1016/j.ijbiomac.2025.142558

Effects of natural polymers for enhanced silica-based mesoporous drug carrier

Alireza Aramideh, Mohsen Ashjari and Zahra Niazi

Journal of Drug Delivery Science and Technology, 2023, 81, 104189
DOI: 10.1016/j.jddst.2023.104189

Antimicrobial action of mesoporous silica nanoparticles loaded with cefepime and meropenem separately against multidrug-resistant (MDR) Acinetobacter baumannii

Afsaneh Najafi, Pegah Khosravian, Majid Validi, Mohammad Porgham Daryasari, Fatemeh Drees and Abolfazl Gholipour

Journal of Drug Delivery Science and Technology, 2021, 65, 102757
DOI: 10.1016/j.jddst.2021.102757

A biocompatible theranostic nanoplatform based on magnetic gadolinium-chelated polycyclodextrin: in vitro and in vivo studies

Hedieh Mansouri, Elham Gholibegloo, Tohid Mortezazadeh, Mohammad Hossein Yazdi, Fatemeh Ashouri, Reza Malekzadeh, Alireza Najafi, Alireza Foroumadi and Mehdi Khoobi

Carbohydrate Polymers, 2021, 254, 117262
DOI: 10.1016/j.carbpol.2020.117262

Polymeric Liposome-Silica Hybrid Nanocarriers as Stimuli-Responsive Systems for Targeted Drug Delivery

Tien-Dung Nguyen-Dinh, Ngoc Hoi Nguyen, Pham Nguyen Dong Yen, Minh Hoang Vo Do, Dai Hai Nguyen, Ching Yern Chee and Ngoc Thuy Trang Le

J Polym Environ, 2025, 33, 5443
DOI: 10.1007/s10924-025-03698-y

Design and characterization of dual responsive mesoporous silica nanoparticles for breast cancer targeted therapy

Dhaval B. Bhavsar, Vijay Patel and Krutika K. Sawant

European Journal of Pharmaceutical Sciences, 2020, 152, 105428
DOI: 10.1016/j.ejps.2020.105428

Regenerated silk fibroin-based dressing modified with carnosine-bentonite nanosheets accelerates healing of second-degree burn wound

Pegah Azimzadeh Asiabi, Ali Ramazani, Mehdi Khoobi, Mohsen Amin, Marzieh Shakoori, Navid Mirmohammad Sadegh and Ramtin Farhadi

Chem. Pap., 2020, 74, 3243
DOI: 10.1007/s11696-020-01155-9

Membrane-cloaked polydopamine modified mesoporous silica nanoparticles for cancer therapy

Zeyu Wang, Jinyan Shi, Hao Pan, Mingxia Liu, Yuli Sang, Jiao Ai, Yang Liu and Lijiang Chen

Nanotechnology, 2022, 33, 345101
DOI: 10.1088/1361-6528/ac6fee

Hybrid Nanoparticles Dual‐Loaded With Curcumin and Benzydamine Hydrochloride for the Treatment of Vulvovaginal Candidiasis: From Development to Biological Application In Vitro and In Vivo

Gabriela C. Carvalho, Maria Nolasco Viseu Domingues, Gabriel Davi Marena, Ermei Mäkilä, Jiachen Li, Gésinda Geertsema‐Doornbusch, Cleverton Roberto de Andrade, Marc C. A. Stuart, Mohammad‐Ali Shahbazi, Ione Corrêa, Brandon W. Peterson, Jarno Salonen, Helena F. Florindo, Taís Maria Bauab, Marlus Chorilli and Hélder A. Santos

Advanced Therapeutics, 2025, 8
DOI: 10.1002/adtp.202400342

Magnetic bio-metal–organic framework nanocomposites decorated with folic acid conjugated chitosan as a promising biocompatible targeted theranostic system for cancer treatment

Vajihe Nejadshafiee, Hossein Naeimi, Bahram Goliaei, Bahareh Bigdeli, Armin Sadighi, Sadegh Dehghani, Alireza Lotfabadi, Maryam Hosseini, Maryam Sadat Nezamtaheri, Massoud Amanlou, Mohammad Sharifzadeh and Mehdi Khoobi

Materials Science and Engineering: C, 2019, 99, 805
DOI: 10.1016/j.msec.2019.02.017

Engineering bipedal Janus nanocarriers: Dual-targeting and pH/microwave-responsive drug delivery system for cancer therapy

Rong Wang and Xiaodan Kong

Microporous and Mesoporous Materials, 2025, 398, 113820
DOI: 10.1016/j.micromeso.2025.113820

Poly-l-lactic acid scaffold incorporated chitosan-coated mesoporous silica nanoparticles as pH-sensitive composite for enhanced osteogenic differentiation of human adipose tissue stem cells by dexamethasone delivery

Mohammad Porgham Daryasari, Mehdi Dusti Telgerd, Mohammad Hossein Karami, Ali Zandi-Karimi, Hamid Akbarijavar, Mehdi Khoobi, Ehsan Seyedjafari, Gebremariam Birhanu, Pegah Khosravian and Fatemeh SadatMahdavi

Artificial Cells, Nanomedicine, and Biotechnology, 2019, 47, 4020
DOI: 10.1080/21691401.2019.1658594

Folic Acid-Chitosan Conjugated Mesoporous Silica Nanoparticles for Enhanced Piceatannol Uptake in MCF-7 Breast Cancer Cells

Santosh Sarnaik, Hafiz Ahmed, Nazir Hussain, Sourav Kundu, Bidya Dhar Sahu and Amit Alexander

ACS Omega, 2025, 10, 45417
DOI: 10.1021/acsomega.5c05302

Cellular Uptake of Modified Mesoporous Bioactive Glass Nanoparticles for Effective Intracellular Delivery of Therapeutic Agents

Negar Hassani Besheli, Juul Verbakel, Maryam Hosseini, Lea Andrée, Ben Joosten, X Frank Walboomers, Alessandra Cambi, Fang Yang and Sander CG Leeuwenburgh

IJN, 2023, Volume 18, 1599
DOI: 10.2147/IJN.S397297

Rational design of hollow mesoporous titania nanoparticles loaded with curcumin for UV-controlled release and targeted drug delivery

Zhuoxian Mai, Jiali Chen, Qingyun Cao, Yang Hu, Xianming Dong, Hongwu Zhang, Wenhua Huang and Wuyi Zhou

Nanotechnology, 2021, 32, 205604
DOI: 10.1088/1361-6528/abe4fe

Fabrication and assessment of folic acid conjugated-chitosan modified PLGA nanoparticle for delivery of alpha terpineol in colon cancer

Amir Rahmati, Masoud Homayouni Tabrizi, Ehsan Karimi and Bahar Zarei

Journal of Biomaterials Science, Polymer Edition, 2022, 33, 1289
DOI: 10.1080/09205063.2022.2051693

Chitosan-glucuronic acid conjugate coated mesoporous silica nanoparticles: A smart pH-responsive and receptor-targeted system for colorectal cancer therapy

Reema Narayan, Shivaprasad Gadag, Sri Pragnya Cheruku, Ashok M. Raichur, Candace Minhthu Day, Sanjay Garg, Suman Manandhar, Karkala Sreedhara Ranganath Pai, Akhil Suresh, Chetan Hasmukh Mehta, Yogendra Nayak, Nitesh Kumar and Usha Yogendra Nayak

Carbohydrate Polymers, 2021, 261, 117893
DOI: 10.1016/j.carbpol.2021.117893

Synthesis of Magnetic Nanocarrier Conjugated by Folate Based on Tragacanth and In Vitro Investigation of their Efficiency on Breast Cancer Cells

Somayeh Jalali, Peyman Najafi Moghadam and Vahid Shafiei‐Irannejad

Starch Stärke, 2023, 75
DOI: 10.1002/star.202200092

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

Nittiya Suwannasom, Netsai Sriaksorn, Chutamas Thepmalee, Krissana Khoothiam, Ausanai Prapan, Hans Bäumler and Chonthida Thephinlap

Beilstein J. Nanotechnol., 2023, 14, 1127
DOI: 10.3762/bjnano.14.93

Biodegradable and biocompatible subcutaneous implants consisted of pH-sensitive mebendazole-loaded/folic acid-targeted chitosan nanoparticles for murine triple-negative breast cancer treatment

Amirhosein Kefayat, Maryam Hosseini, Fatemeh Ghahremani, Nafise Arbab Jolfaie and Mohammad Rafienia

J Nanobiotechnol, 2022, 20
DOI: 10.1186/s12951-022-01380-2

A Comprehensive Study on Folate-Targeted Mesoporous Silica Nanoparticles Loaded with 5-Fluorouracil for the Enhanced Treatment of Gynecological Cancers

Aliyah Almomen and Adel Alhowyan

JFB, 2024, 15, 74
DOI: 10.3390/jfb15030074

Alginate-bentonite composite decorated by chitosan-folate conjugate for the oral delivery of 5-Fluorouracil

R. Surya, Manohar D Mullassery, Noeline B Fernandez and Diana Thomas

Analytical Chemistry Letters, 2023, 13, 461
DOI: 10.1080/22297928.2023.2263018

Chitosan-based antibacterial microspheres loaded multifunctional Janus composite membranes with unidirectional biofluid transport, antioxidant and pH-responsive monitoring

Ting-Ting Li, Li Sun, Ying Zhang, Bing-Chiuan Shiu, Hai-Tao Ren, Hao-Kai Peng, Jia-Horng Lin and Ching-Wen Lou

Chemical Engineering Journal, 2023, 472, 144820
DOI: 10.1016/j.cej.2023.144820

Anticancer Potential of Temozolomide-Loaded Eudragit-Chitosan Coated Selenium Nanoparticles: In Vitro Evaluation of Cytotoxicity, Apoptosis and Gene Regulation

Madineh Mazarei, Pooria Mohammadi Arvejeh, M. R. Mozafari, Pegah Khosravian and Sorayya Ghasemi

Nanomaterials, 2021, 11, 1704
DOI: 10.3390/nano11071704

Synergistic cytotoxicity of erianin, a bisbenzyl in the dietetic Chinese herb Dendrobium against breast cancer cells

Hualing Xie, Simin Feng, Mohamed Ali Farag, Peilong Sun and Ping Shao

Food and Chemical Toxicology, 2021, 149, 111960
DOI: 10.1016/j.fct.2020.111960

Theranostic α-Lactalbumin-Polymer-Based Nanocomposite as a Drug Delivery Carrier for Cancer Therapy

Behdad Delavari, Bahareh Bigdeli, Fatemeh Mamashli, Mahdi Gholami, Behrouz Bazri, Mehdi Khoobi, Atiyeh Ghasemi, Hadi Baharifar, Sadegh Dehghani, Elham Gholibegloo, Amir Amani, Nader Riahi-Alam, Shahin Ahmadian, Bahram Goliaei, Naisana S. Asli, Ali Hossein Rezayan, Ali Akbar Saboury and Pegah Varamini

ACS Biomater. Sci. Eng., 2019, 5, 5189
DOI: 10.1021/acsbiomaterials.9b01236

Development of Novel Chimeric Endolysin Conjugated with Chitosan-Zn-Metal–Organic Framework Nanocomposites with Antibacterial Activity

Mahnaz Malekian, Hossein Fahimi, Neda Mousavi Niri and Sepideh Khaleghi

Appl Biochem Biotechnol, 2024, 196, 616
DOI: 10.1007/s12010-023-04514-w

Lymphatic clearance is the main drainage route of lamotrigine-loaded micelles following delivery to the brain

Jiaqi Yan, Jialin Ren, Yu Zhu, Yanzhen Lin, Gang Chen, Dongzhi Hou, Zhufen Lv, Jiaxin Zhou, Yanzhong Chen and Fan Yang

Journal of Pharmacy and Pharmacology, 2019, 71, 1488
DOI: 10.1111/jphp.13137

Review of Curcumin Physicochemical Targeting Delivery System

Lanmei Li, Xiaomei Zhang, Chao Pi, Hongru Yang, Xiaoli Zheng, Ling Zhao and Yumeng Wei

IJN, 2020, Volume 15, 9799
DOI: 10.2147/IJN.S276201

pH-sensitive biocompatible mesoporous magnetic nanoparticles labeled with folic acid as an efficient carrier for controlled anticancer drug delivery

Ninet Avedian, Farzaaneh Zaaeri, Mohammad Porgham Daryasari, Hamid Akbari Javar and Mehdi Khoobi

Journal of Drug Delivery Science and Technology, 2018, 44, 323
DOI: 10.1016/j.jddst.2018.01.006

Polyethylenimine-graft-poly (maleic anhydride-alt-1-octadecene) coated Fe3O4magnetic nanoparticles: promising targeted pH-sensitive system for curcumin delivery and MR imaging

Haniyeh Molaei, Farzaaneh Zaaeri, Sharareh Sharifi, Ali Ramazani, Saeed Safaei, Jamil Abdolmohammadi and Mehdi Khoobi

International Journal of Polymeric Materials and Polymeric Biomaterials, 2021, 70, 1344
DOI: 10.1080/00914037.2020.1798435

Folic acid-functionalized cerium oxide nanoparticles as smart nanocarrier for pH-responsive and targeted delivery of Morin in breast cancer therapy

Neelam Thakur, Pritam Sadhukhan, Mousumi Kundu, Th. Abhishek Singh, Madushmita Hatimuria, Ashok Pabbathi, Joydeep Das and Parames C. Sil

Inorganic Chemistry Communications, 2022, 145, 109976
DOI: 10.1016/j.inoche.2022.109976

Curcumin-loaded mesoporous silica nanoparticles with dual-imaging and temperature control inhibits the infection of Zika virus

Tzu-Hsuan Lo, Zhi-Yuan Wu, Shiow-Yi Chen, Fan-Yi Meng, Pi-Tai Chou, Chih-Min Wang and Hsiu-Mei Lin

Microporous and Mesoporous Materials, 2021, 314, 110886
DOI: 10.1016/j.micromeso.2021.110886

Multifunctional Gold Helix Phototheranostic Biohybrid That Enables Targeted Image-Guided Photothermal Therapy in Breast Cancer

Maryam Hosseini, Zahed Ahmadi, Amirhosein Kefayat, Fatemeh Molaabasi, Anita Ebrahimpour, Yousef Naderi Khojasteh far and Mehdi Khoobi

ACS Appl. Mater. Interfaces, 2022, 14, 37447
DOI: 10.1021/acsami.2c10028

Improved curcumin loading, release, solubility and toxicity by tuning the molar ratio of cross-linker to β-cyclodextrin

Elham Gholibegloo, Tohid Mortezazadeh, Fatemeh Salehian, Ali Ramazani, Massoud Amanlou and Mehdi Khoobi

Carbohydrate Polymers, 2019, 213, 70
DOI: 10.1016/j.carbpol.2019.02.075

Camptothecin-loaded mesoporous silica nanoparticles functionalized with CpG oligodeoxynucleotide as a new approach for skin cancer treatment

Munibah Qureshi, Cláudia Viegas, Sofia O.D. Duarte, Michael Girardi, Adeeb Shehzad and Pedro Fonte

International Journal of Pharmaceutics, 2024, 660, 124340
DOI: 10.1016/j.ijpharm.2024.124340

Physico-biochemical Properties of Chitosan-poly(N-[3-(dimethylaminopropyl)] methacrylamide) Copolymers Synthesized as siRNA Carrier Biomaterials

Ceyda Şimşek, Erhan Demirel, Semih Macit, Yasemin Yüksel Durmaz and Candan Erbil

ACS Omega, 2025, 10, 42019
DOI: 10.1021/acsomega.5c06839