Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology

Joanna I. Zaitseva-Kinneberg, Anke Puchert, Yannik Pfeifer, Hao Yan, Briony A. Yorke, Henrike M. Müller-Werkmeister, Charlotte Uetrecht, Julia Rehbein, Nils Huse, Arwen R. Pearson and Marta Sans

RSC Adv., 2019, 9, 8695
DOI: 10.1039/C9RA00968J

A study on the applicability of l-aspartate α-decarboxylase in the biobased production of nitrogen containing chemicals

Paul M. Könst, Maurice C. R. Franssen, Elinor L. Scott and Johan P. M. Sanders

Green Chem., 2009, 11, 1646
DOI: 10.1039/b902731a

Rational molecular engineering ofl-amino acid deaminase for production of α-ketoisovaleric acid froml-valine by Escherichia coli

Ruoxi Li, Hossain Gazi Sakir, Jianghua Li, Hyun-dong Shin, Guocheng Du, Jian Chen and Long Liu

RSC Adv., 2017, 7, 6615
DOI: 10.1039/C6RA26972A

Elucidating biosynthetic pathways for vitamins and cofactors

Michael E. Webb, Andrée Marquet, Ralf R. Mendel, Fabrice Rébeillé and Alison G. Smith

Nat. Prod. Rep., 2007, 24, 988
DOI: 10.1039/b703105j

The design and synthesis of inhibitors of pantothenate synthetase

Kellie L. Tuck, S. Adrian Saldanha, Louise M. Birch, Alison G. Smith and Chris Abell

Org. Biomol. Chem., 2006, 4, 3598
DOI: 10.1039/b609482a

Biosynthesis of natural products containing β-amino acids

Fumitaka Kudo, Akimasa Miyanaga and Tadashi Eguchi

Nat. Prod. Rep., 2014, 31, 1056
DOI: 10.1039/C4NP00007B

Engineered ketoreductase-catalyzed stereoselective reduction of ethyl 2′-ketopantothenate and its analogues: chemoenzymatic synthesis of d-pantothenic acid

Pan Hu, Xiaofan Wu, Yajiao Zhang, Minjie Liu, Yuan Tao, Zedu Huang and Fener Chen

Green Chem., 2024, 26, 2124
DOI: 10.1039/D3GC04344D

Fragment-based approaches to TB drugs

CHIARA MARCHETTI, DANIEL S. H. CHAN, ANTHONY G. COYNE and CHRIS ABELL

Parasitology, 2018, 145, 184
DOI: 10.1017/S0031182016001876

The Synthesis and Role of β-Alanine in Plants

Anutthaman Parthasarathy, Michael A. Savka and André O. Hudson

Front. Plant Sci., 2019, 10
DOI: 10.3389/fpls.2019.00921

Loss of Dihydroxyacid Dehydratase Induces Auxotrophy in Bacillus anthracis

Joseph Jelinski, Madeline Cortez, Austen Terwilliger, Justin Clark, Anthony Maresso and Michael J. Federle

J Bacteriol, 2021, 203
DOI: 10.1128/JB.00415-21

Uncovering phytochemicals quantitative evolution in avocado fruit mesocarp during ripening: A targeted LC-MS metabolic exploration of Hass, Fuerte and Bacon varieties

Irene Serrano-García, Carlos Saavedra Morillas, María Gemma Beiro-Valenzuela, Romina Monasterio, Elena Hurtado-Fernández, José Jorge González-Fernández, José Ignacio Hormaza, Romina Pedreschi, Lucía Olmo-García and Alegría Carrasco-Pancorbo

Food Chemistry, 2024, 459, 140334
DOI: 10.1016/j.foodchem.2024.140334

A Fragment‐Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry

Duncan E. Scott, Gwen J. Dawes, Michiyo Ando, Chris Abell and Alessio Ciulli

ChemBioChem, 2009, 10, 2772
DOI: 10.1002/cbic.200900537

Metabolomic analysis of methane-reducing seaweed Asparagopsis taxiformis for sustainable production in Taiwan

Zi-Yan Xu, Chen-Hsun Liu, Bonien Chen, Li-Lien Liu, Jen-Lung Lo, Chiu-Hui Kuo and Kuohsun Chiu

Science of The Total Environment, 2025, 971, 179045
DOI: 10.1016/j.scitotenv.2025.179045

Inhibition of Pantothenate Synthetase by Analogs of β-Alanine Precursor Ineffective as an Antibacterial Strategy

S. Imindu Liyanage, Mayuri Gupta, Fan Wu, Marcy Taylor, Michael D. Carter and Donald F. Weaver

Chemotherapy, 2019, 64, 22
DOI: 10.1159/000499899

Plants need their vitamins too

Alison G Smith, Martin T Croft, Michael Moulin and Michael E Webb

Current Opinion in Plant Biology, 2007, 10, 266
DOI: 10.1016/j.pbi.2007.04.009

Diversity of membrane transport proteins for vitamins in bacteria and archaea

Michael Jaehme and Dirk Jan Slotboom

Biochimica et Biophysica Acta (BBA) - General Subjects, 2015, 1850, 565
DOI: 10.1016/j.bbagen.2014.05.006

Threonine 57 is required for the post-translational activation ofEscherichia coliaspartate α-decarboxylase

Michael E. Webb, Briony A. Yorke, Tom Kershaw, Sarah Lovelock, Carina M. C. Lobley, Mairi L. Kilkenny, Alison G. Smith, Tom L. Blundell, Arwen R. Pearson and Chris Abell

Acta Crystallogr D Biol Crystallogr, 2014, 70, 1166
DOI: 10.1107/S1399004713034275

Stable isotope dilution liquid chromatography/mass spectrometry analysis of cellular and tissue medium‐ and long‐chain acyl‐coenzyme A thioesters

Nathaniel W. Snyder, Sankha S. Basu, Zinan Zhou, Andrew J. Worth and Ian A. Blair

Rapid Comm Mass Spectrometry, 2014, 28, 1840
DOI: 10.1002/rcm.6958

A highly active pantothenate synthetase from Corynebacterium glutamicum enables the production of d-pantothenic acid with high productivity

Fitsum Tigu, Junli Zhang, Guoxia Liu, Zhen Cai and Yin Li

Appl Microbiol Biotechnol, 2018, 102, 6039
DOI: 10.1007/s00253-018-9017-2

Ultra-performance liquid chromatography (UPLC) for the determination of organic acids – The intermediates of branched-chain amino acid biosynthesis in Escherichia coli strains

Elizaveta N. Fedorova, Darya O. Varlamova, Alexandr D. Kivero, Kristina D. Guk and Leonid R. Ptitsyn

Journal of Liquid Chromatography & Related Technologies, 2020, 43, 844
DOI: 10.1080/10826076.2020.1832894

Identification of dihydropyrimidine dehydrogenase as a virulence factor essential for the survival ofEntamoeba histolyticain glucose-poor environments

Sharon Baumel-Alterzon, Christian Weber, Nancy Guillén and Serge Ankri

Cell Microbiol, 2013, 15, 130
DOI: 10.1111/cmi.12036

Strengthening the (R)-pantoate pathway to produce D-pantothenic acid based on systematic metabolic analysis

Bo Zhang, Li Chen, Jie-Yi Jin, Na Zhong, Xue Cai, Shu-Ping Zou, Hai-Yan Zhou, Zhi-Qiang Liu and Yu-Guo Zheng

Food Bioscience, 2021, 43, 101283
DOI: 10.1016/j.fbio.2021.101283

Crystal Structure of Escherichia coli Ketopantoate Reductase in a Ternary Complex with NADP+ and Pantoate Bound

Alessio Ciulli, Dimitri Y. Chirgadze, Alison G. Smith, Tom L. Blundell and Chris Abell

Journal of Biological Chemistry, 2007, 282, 8487
DOI: 10.1074/jbc.M611171200

A putative terpene cyclase gene (CcPtc1) is required for fungal development and virulence in Cytospora chrysosperma

Yuchen Yang, Lu Yu, Xiaolin Qiu, Dianguang Xiong and Chengming Tian

Front. Microbiol., 2023, 14
DOI: 10.3389/fmicb.2023.1084828

Substrate inactivation of bacterial l-aspartate α-decarboxylase from Corynebacterium jeikeium K411 and improvement of molecular stability by saturation mutagenesis

Qin Mo, An Mao, Youran Li and Guiyang Shi

World J Microbiol Biotechnol, 2019, 35
DOI: 10.1007/s11274-019-2629-6

Plant amino acid-derived vitamins: biosynthesis and function

Javier A. Miret and Sergi Munné-Bosch

Amino Acids, 2014, 46, 809
DOI: 10.1007/s00726-013-1653-3

Uncovering metabolic pathways relevant to phenotypic traits of microbial genomes

Gabi Kastenmüller, Maria Elisabeth Schenk, Johann Gasteiger and Hans-Werner Mewes

Genome Biol, 2009, 10
DOI: 10.1186/gb-2009-10-3-r28

Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors

Michaelyn C. Lux, Lisa C. Standke and Derek S. Tan

J Antibiot, 2019, 72, 325
DOI: 10.1038/s41429-019-0171-2

A continuous kinetic assay for adenylation enzyme activity and inhibition

Daniel J. Wilson and Courtney C. Aldrich

Analytical Biochemistry, 2010, 404, 56
DOI: 10.1016/j.ab.2010.04.033

Label-free quantitative proteomic analysis of the inhibition effect of Lactobacillus rhamnosus GG on Escherichia coli biofilm formation in co-culture

Huiyi Song, Ni Lou, Jianjun Liu, Hong Xiang and Dong Shang

Proteome Sci, 2021, 19
DOI: 10.1186/s12953-021-00172-0

Metabolic Engineering of Microbial Chassis Cells for d-Pantothenate Production: A Review

Fang-Ying Zhu, Yun-Yue Gu, Xue Cai, Jun-Ping Zhou, Yuan-Yuan Chen, Yi-Hong Wang, Bo Zhang, Zhi-Qiang Liu and Yu-Guo Zheng

ACS Synth. Biol., 2025, 14, 3831
DOI: 10.1021/acssynbio.5c00283

Design, Synthesis, Pharmacological Evaluation, In silico Modeling, Prediction of Toxicity and Metabolism Studies of Novel 1-(substituted)-2-methyl- 3-(4-oxo-2-phenyl quinazolin-3(4H)-yl)isothioureas

Mohaideen Thasthagir Sulthana, Veerachamy Alagarsamy and Krishnan Chitra

MC, 2021, 17, 352
DOI: 10.2174/1573406416666200817153033

Metabolic repair through emergence of new pathways in Escherichia coli

Sammy Pontrelli, Riley C. B. Fricke, Shao Thing Teoh, Walter A. Laviña, Sastia Prama Putri, Sorel Fitz-Gibbon, Matthew Chung, Matteo Pellegrini, Eiichiro Fukusaki and James C. Liao

Nat Chem Biol, 2018, 14, 1005
DOI: 10.1038/s41589-018-0149-6

Research progress of l-aspartate-α-decarboxylase and its isoenzyme in the β-alanine synthesis

Zhong-Ce Hu, Yu-Hang Tian, Jia-Li Yang, Ya-Nan Zhu, Hai-Yan Zhou, Yu-Guo Zheng and Zhi-Qiang Liu

World J Microbiol Biotechnol, 2023, 39
DOI: 10.1007/s11274-022-03483-2

Major urinary protein ( Mup ) gene family deletion drives sex-specific alterations in the house-mouse gut microbiota

Madalena V. F. Real, Melanie S. Colvin, Michael J. Sheehan, Andrew H. Moeller and Jan Claesen

Microbiol Spectr, 2024, 12
DOI: 10.1128/spectrum.03566-23

Degradation of agricultural polyethylene film by greater wax moth (Galleria mellonella) larvae and screening of involved gut bacteria

Qing Ma, Yule Qian, Weisi Su, Lanxin Shi, Enjun Wang, Aixian Yu, Junjie Zheng and Yin Lu

Ecotoxicology and Environmental Safety, 2025, 303, 118841
DOI: 10.1016/j.ecoenv.2025.118841

Vitamin in the Crosshairs: Targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents

Hailey S. Butman, Timothy J. Kotzé, Cynthia S. Dowd and Erick Strauss

Front. Cell. Infect. Microbiol., 2020, 10
DOI: 10.3389/fcimb.2020.605662

Molecular Properties of Bare and Microhydrated Vitamin B5–Calcium Complexes

Davide Corinti, Barbara Chiavarino, Debora Scuderi, Caterina Fraschetti, Antonello Filippi, Simonetta Fornarini and Maria Elisa Crestoni

IJMS, 2021, 22, 692
DOI: 10.3390/ijms22020692

Targeting metabolic driving and minimization of by‐products synthesis for high‐yield production of D‐pantothenate in Escherichia coli

Bo Li, Bo Zhang, Pei Wang, Xue Cai, Ya‐Qun Tang, Jie‐Yi Jin, Jin‐Xi Liang, Zhi‐Qiang Liu and Yu‐Guo Zheng

Biotechnology Journal, 2022, 17
DOI: 10.1002/biot.202100431

The Bewildering Antitubercular Action of Pyrazinamide

Elise A. Lamont, Nicholas A. Dillon and Anthony D. Baughn

Microbiol Mol Biol Rev, 2020, 84
DOI: 10.1128/MMBR.00070-19

Chemoinformatic Identification of Novel Inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase

Reetu Sharma, Roopa Kothapalli, Antonius M. J. Van Dongen, Kunchithapadam Swaminathan and Chandra Verma

PLoS ONE, 2012, 7, e33521
DOI: 10.1371/journal.pone.0033521

Role of Glutamate Decarboxylase-like Protein 1 (GADL1) in Taurine Biosynthesis

Pingyang Liu, Xiaomei Ge, Haizhen Ding, Honglin Jiang, Bruce M. Christensen and Jianyong Li

Journal of Biological Chemistry, 2012, 287, 40898
DOI: 10.1074/jbc.M112.393728

Impact of the host environment on the antitubercular action of pyrazinamide

Elise A. Lamont and Anthony D. Baughn

eBioMedicine, 2019, 49, 374
DOI: 10.1016/j.ebiom.2019.10.014

Association between plasma vitamin B5 and coronary heart disease: Results from a case-control study

Pengfei Sun, Haoyu Weng, Fangfang Fan, Nan Zhang, Zhihao Liu, Ping Chen, Jia Jia, Bo Zheng, Tieci Yi, Yuxi Li, Yan Zhang and Jianping Li

Front. Cardiovasc. Med., 2022, 9
DOI: 10.3389/fcvm.2022.906232

A Perspective on the Strategic Application of Deconstruction–Reconstruction in Drug Discovery

J. Henry Blackwell, Iacovos N. Michaelides and Floriane Gibault

J. Med. Chem., 2025, 68, 10520
DOI: 10.1021/acs.jmedchem.5c00036

Quantitative Mass Spectrometry Reveals Plasticity of Metabolic Networks in Mycobacterium smegmatis

Tarun Chopra, Romain Hamelin, Florence Armand, Diego Chiappe, Marc Moniatte and John D. McKinney

Molecular & Cellular Proteomics, 2014, 13, 3014
DOI: 10.1074/mcp.M113.034082

Salmonella exploits host- and bacterial-derived β-alanine for replication inside host macrophages

Shuai Ma, Bin Yang, Yuyang Sun, Xinyue Wang, Houliang Guo, Ruiying Liu, Ting Ye, Chenbo Kang, Jingnan Chen and Lingyan Jiang

eLife, 2025, 13
DOI: 10.7554/eLife.103714.4

Biosynthesis of Pantothenic Acid and Coenzyme A

Roberta Leonardi, Suzanne Jackowski and Thomas J. Begley

EcoSal Plus, 2007, 2
DOI: 10.1128/ecosalplus.3.6.3.4

Interaction of D-panthenol with water molecules – Experimental and computational study

Milan Vraneš, Jovana Panić, Aleksandar Tot, Snežana Papović, Maksim Rapaić and Slobodan Gadžurić

The Journal of Chemical Thermodynamics, 2018, 118, 34
DOI: 10.1016/j.jct.2017.10.014

Crystal structure of archaeal ketopantoate reductase complexed with coenzyme a and 2‐oxopantoate provides structural insights into feedback regulation

Yoshiki Aikawa, Yuichi Nishitani, Hiroya Tomita, Haruyuki Atomi and Kunio Miki

Proteins, 2016, 84, 374
DOI: 10.1002/prot.24984

3‐Fluoroaspartate and Pyruvoyl‐Dependant Aspartate Decarboxylase: Exploiting the Unique Characteristics of Fluorine To Probe Reactivity and Binding

Jandré de Villiers, Lizbé Koekemoer and Erick Strauss

Chemistry A European J, 2010, 16, 10030
DOI: 10.1002/chem.201000622

Pyrimidine Metabolism: Dynamic and Versatile Pathways in Pathogens and Cellular Development

Manuel F. Garavito, Heidy Y. Narváez-Ortiz and Barbara H. Zimmermann

Journal of Genetics and Genomics, 2015, 42, 195
DOI: 10.1016/j.jgg.2015.04.004

The pathogenic mechanism of Mycobacterium tuberculosis: implication for new drug development

Weizhu Yan, Yanhui Zheng, Chao Dou, Guixiang Zhang, Toufic Arnaout and Wei Cheng

Mol Biomed, 2022, 3
DOI: 10.1186/s43556-022-00106-y

De novo biosynthesis of D-panthenol in engineered E. coli with rationally designed L-homoserine decarboxylase

Peng Zheng, Jie Ren, Jie Zheng, Feixia Liu, Xinhao Han and Bo Yu

Metabolic Engineering, 2025, 92, 63
DOI: 10.1016/j.ymben.2025.07.013

NMR-Based Metabonomic Analysis of Physiological Responses to Starvation and Refeeding in the Rat

José I. Serrano-Contreras, Isabel García-Pérez, María E. Meléndez-Camargo and L. Gerardo Zepeda

J. Proteome Res., 2016, 15, 3241
DOI: 10.1021/acs.jproteome.6b00433

Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase

Zhixiang Xu, Wei Yin, Leonardo K. Martinelli, Joanna Evans, Jinglei Chen, Yang Yu, Daniel J. Wilson, Valerie Mizrahi, Chunhua Qiao and Courtney C. Aldrich

Bioorganic & Medicinal Chemistry, 2014, 22, 1726
DOI: 10.1016/j.bmc.2014.01.017

Improved production of D-pantothenic acid in Escherichia coli by integrated strain engineering and fermentation strategies

Shuping Zou, Kuo Zhao, Heng Tang, Zheng Zhang, Bo Zhang, Zhiqiang Liu and Yuguo Zheng

Journal of Biotechnology, 2021, 339, 65
DOI: 10.1016/j.jbiotec.2021.07.014

Confirmation of a Protein–Protein Interaction in the Pantothenate Biosynthetic Pathway by Using Sortase‐Mediated Labelling

Philip M. Morrison, Matthew R. Balmforth, Samuel W. Ness, Daniel J. Williamson, Michael D. Rugen, W. Bruce Turnbull and Michael E. Webb

ChemBioChem, 2016, 17, 753
DOI: 10.1002/cbic.201500547

Chlorflavonin Targets Acetohydroxyacid Synthase Catalytic Subunit IlvB1 for Synergistic Killing of Mycobacterium tuberculosis

Nidja Rehberg, Herve Sergi Akone, Thomas R. Ioerger, German Erlenkamp, Georgios Daletos, Holger Gohlke, Peter Proksch and Rainer Kalscheuer

ACS Infect. Dis., 2018, 4, 123
DOI: 10.1021/acsinfecdis.7b00055

Cloning and overexpression of ketopantoic acid reductase gene from Stenotrophomonas maltophilia and its application to stereospecific production of d-pantoic acid

Dayong Si, Nobuyuki Urano, Sakayu Shimizu and Michihiko Kataoka

Appl Microbiol Biotechnol, 2012, 93, 1619
DOI: 10.1007/s00253-011-3664-x

How an overlooked gene in coenzyme a synthesis solved an enzyme mechanism predicament

John E. Cronan

Molecular Microbiology, 2023, 119, 687
DOI: 10.1111/mmi.15070

Metabolic engineering of Escherichia coli for d-pantothenic acid production

Bo Zhang, Xiao-Ming Zhang, Wei Wang, Zhi-Qiang Liu and Yu-Guo Zheng

Food Chemistry, 2019, 294, 267
DOI: 10.1016/j.foodchem.2019.05.044

Metabolic engineering of Escherichia coli for improved d-pantothenic acid biosynthesis by enhancing NADPH availability

Shuping Zou, Zheng Zhang, Kuo Zhao, Zhiqiang Liu and Yuguo Zheng

Biochemical Engineering Journal, 2022, 187, 108603
DOI: 10.1016/j.bej.2022.108603

Biosynthesis of Pantothenate

Michael E. Webb, Alison G. Smith and Chris Abell

ChemInform, 2005, 36
DOI: 10.1002/chin.200514279

Structure ofEscherichia coliaspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation

Michael E. Webb, Carina M. C. Lobley, Fatima Soliman, Mairi L. Kilkenny, Alison G. Smith, Tom L. Blundell and Chris Abell

Acta Crystallogr F Struct Biol Cryst Commun, 2012, 68, 414
DOI: 10.1107/S1744309112009487

Metabolic Engineering of Saccharomyces cerevisiae for Vitamin B5 Production

Jiaxuan Guo, Xixi Sun, Yujie Yuan, Qitong Chen, Zutian Ou, Zixin Deng, Tian Ma and Tiangang Liu

J. Agric. Food Chem., 2023, 71, 7408
DOI: 10.1021/acs.jafc.3c01082

Crystal structure of ketopantoate reductase fromThermococcus kodakarensiscomplexed with NADP+

Yoshiki Aikawa, Yuichi Nishitani, Hiroya Tomita, Haruyuki Atomi and Kunio Miki

Acta Crystallogr F Struct Biol Commun, 2016, 72, 369
DOI: 10.1107/S2053230X16005033

Nucleoside Analogs and Tuberculosis: New Weapons Against an Old Enemy

Valentina Ferrari and Michaela Serpi

Future Med. Chem., 2015, 7, 291
DOI: 10.4155/fmc.14.166

Vitamin B5 and vitamin U review: justification of combined use for the treatment of mucosa-associated gastrointestinal pathologies

Valentin P. Shichkin

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1587627

Experimental Raman and IR spectral and theoretical studies of vibrational spectrum and molecular structure of Pantothenic acid (vitamin B5)

Mayuri Srivastava, N.P. Singh and R.A. Yadav

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 129, 131
DOI: 10.1016/j.saa.2014.02.121

Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5

Marcel Hrubša, Tomáš Siatka, Iveta Nejmanová, Marie Vopršalová, Lenka Kujovská Krčmová, Kateřina Matoušová, Lenka Javorská, Kateřina Macáková, Laura Mercolini, Fernando Remião, Marek Máťuš and Přemysl Mladěnka

Nutrients, 2022, 14, 484
DOI: 10.3390/nu14030484

Biochemical Features and Functional Implications of the RNA-Based T-Box Regulatory Mechanism

Ana Gutiérrez-Preciado, Tina M. Henkin, Frank J. Grundy, Charles Yanofsky and Enrique Merino

Microbiol Mol Biol Rev, 2009, 73, 36
DOI: 10.1128/MMBR.00026-08

Hot spot-based engineering of ketopantoate hydroxymethyltransferase for the improvement of D-pantothenic acid production in Escherichia coli

Xue Cai, Xue Shi, Si-Qi Liu, Yu Qiang, Ji-Dong Shen, Bo Zhang, Zhi-Qiang Liu and Yu-Guo Zheng

Journal of Biotechnology, 2023, 364, 40
DOI: 10.1016/j.jbiotec.2023.01.010

An activator for pyruvoyl‐dependent l‐aspartate α‐decarboxylase is conserved in a small group of the γ‐proteobacteria including Escherichia coli

Shingo Nozaki, Michael E. Webb and Hironori Niki

MicrobiologyOpen, 2012, 1, 298
DOI: 10.1002/mbo3.34

Production of stable isotope-labeled acyl-coenzyme A thioesters by yeast stable isotope labeling by essential nutrients in cell culture

Nathaniel W. Snyder, Gregory Tombline, Andrew J. Worth, Robert C. Parry, Jacob A. Silvers, Kevin P. Gillespie, Sankha S. Basu, Jonathan Millen, David S. Goldfarb and Ian A. Blair

Analytical Biochemistry, 2015, 474, 59
DOI: 10.1016/j.ab.2014.12.014

PanG, a New Ketopantoate Reductase Involved in Pantothenate Synthesis

C. N. Miller, E. D. LoVullo, T. M. Kijek, J. R. Fuller, J. C. Brunton, S. P. Steele, S. A. Taft-Benz, A. R. Richardson and T. H. Kawula

Journal of Bacteriology, 2013, 195, 965
DOI: 10.1128/JB.01740-12

2′, 3′, 5′-tri-O-acetyl-N6-(3-hydroxyphenyl) adenosine alleviates diet-induced hyperlipidemia by modulating intestinal gene expression profiles and metabolic pathway

Qifeng Liu, Yue Xu, Xueqi Lv, Congcong Guo, Haibo Zhu, Liu Yang and Yinghong Wang

Life Sciences, 2024, 352, 122891
DOI: 10.1016/j.lfs.2024.122891

Substrate-Induced Closing of the Active Site Revealed by the Crystal Structure of Pantothenate Synthetase from Staphylococcus aureus

Atsuko Satoh, Saki Konishi, Haruka Tamura, Hannah G. Stickland, Heather M. Whitney, Alison G. Smith, Hiroyoshi Matsumura and Tsuyoshi Inoue

Biochemistry, 2010, 49, 6400
DOI: 10.1021/bi1004206

Aspartate α-decarboxylase a new therapeutic target in the fight against Helicobacter pylori infection

Kareem A. Ibrahim, Mona T. Kashef, Tharwat R. Elkhamissy, Mohammed A. Ramadan and Omneya M. Helmy

Front. Microbiol., 2022, 13
DOI: 10.3389/fmicb.2022.1019666

Coenzyme A biosynthesis: an antimicrobial drug target

Christina Spry, Kiaran Kirk and Kevin J. Saliba

FEMS Microbiol Rev, 2008, 32, 56
DOI: 10.1111/j.1574-6976.2007.00093.x

Substrate Diversity of L-Threonic Acid Dehydrogenase Homologs

C. F. Zhang, Y. P. Liu, X. X. Wu, X. S. Zhang and H. Huang

Biochemistry Moscow, 2020, 85, 463
DOI: 10.1134/S0006297920040069

The Mechanism of Regulation of Pantothenate Biosynthesis by the PanD–PanZ·AcCoA Complex Reveals an Additional Mode of Action for the Antimetabolite N-Pentyl Pantothenamide (N5-Pan)

Zoe L. P. Arnott, Shingo Nozaki, Diana C. F. Monteiro, Holly E. Morgan, Arwen R. Pearson, Hironori Niki and Michael E. Webb

Biochemistry, 2017, 56, 4931
DOI: 10.1021/acs.biochem.7b00509

The STM4195 Gene Product (PanS) Transports Coenzyme A Precursors in Salmonella enterica

Dustin C. Ernst, Diana M. Downs and W. W. Metcalf

J Bacteriol, 2015, 197, 1368
DOI: 10.1128/JB.02506-14

Escherichia coli Dihydropyrimidine Dehydrogenase Is a Novel NAD-Dependent Heterotetramer Essential for the Production of 5,6-Dihydrouracil

Ryota Hidese, Hisaaki Mihara, Tatsuo Kurihara and Nobuyoshi Esaki

J Bacteriol, 2011, 193, 989
DOI: 10.1128/JB.01178-10

X‐ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate

Kalyan Sundar Chakrabarti, Krishan Gopal Thakur, B. Gopal and Siddhartha P. Sarma

The FEBS Journal, 2010, 277, 697
DOI: 10.1111/j.1742-4658.2009.07515.x

E, K, B5, B6, and B9 vitamins and their specific immunological effects evaluated by flow cytometry

Camelia Munteanu, Ioana Berindean, Mihaela Mihai, Bianca Pop, Mihai Popa, Leon Muntean, Olivia Petrescu and Andreea Ona

Front. Med., 2023, 9
DOI: 10.3389/fmed.2022.1089476

Formation of a heterooctameric complex between aspartate α-decarboxylase and its cognate activating factor, PanZ, is CoA-dependent

Diana C.F. Monteiro, Michael D. Rugen, Dale Shepherd, Shingo Nozaki, Hironori Niki and Michael E. Webb

Biochemical and Biophysical Research Communications, 2012, 426, 350
DOI: 10.1016/j.bbrc.2012.08.084

Nanostructured Systems Improve the Antimicrobial Potential of the Essential Oil from Cymbopogon densiflorus Leaves

Janaína B. Seibert, Juliana S. R. Viegas, Tamires C. Almeida, Tatiane R. Amparo, Ivanildes V. Rodrigues, Juliane S. Lanza, Frédéric J. G. Frézard, Rodrigo D. O. A. Soares, Luiz Fernando M. Teixeira, Gustavo H. B. de Souza, Paula M. A. Vieira, José M. Barichello and Orlando D. H. dos Santos

J. Nat. Prod., 2019, 82, 3208
DOI: 10.1021/acs.jnatprod.8b00870

Module engineering coupled with omics strategies for enhancing D-pantothenate production in Escherichia coli

Pei Wang, Hai-Yan Zhou, Jun-Ping Zhou, Bo Li, Zhi-Qiang Liu and Yu-Guo Zheng

Bioresource Technology, 2022, 352, 127024
DOI: 10.1016/j.biortech.2022.127024

Nonhydrolyzable d‑phenylalanine-benzoxazole derivatives retain antitubercular activity

Michael J. Pepi, Shibin Chacko, Nicole Kopetz, Helena I.M. Boshoff, Gregory D. Cuny and Lizbeth Hedstrom

Bioorganic & Medicinal Chemistry Letters, 2023, 80, 129116
DOI: 10.1016/j.bmcl.2022.129116

Benefiting others and self: Production of vitamins in plants

Yufei Li, Chenkun Yang, Hasan Ahmad, Mohamed Maher, Chuanying Fang and Jie Luo

JIPB, 2021, 63, 210
DOI: 10.1111/jipb.13047

Multiplex modification of Escherichia coli for enhanced β-alanine biosynthesis through metabolic engineering

Pei Wang, Hai-Yan Zhou, Bo Li, Wen-Qing Ding, Zhi-Qiang Liu and Yu-Guo Zheng

Bioresource Technology, 2021, 342, 126050
DOI: 10.1016/j.biortech.2021.126050

Genome-wide survey and crystallographic analysis suggests a role for both horizontal gene transfer and duplication in pantothenate biosynthesis pathways

Basavraj Khanppnavar, Rakesh Chatterjee, Gourab Basu Choudhury and Saumen Datta

Biochimica et Biophysica Acta (BBA) - General Subjects, 2019, 1863, 1547
DOI: 10.1016/j.bbagen.2019.05.017

Modular Enzymatic Cascade Synthesis of Vitamin B5 and Its Derivatives

Mohammad Z. Abidin, Thangavelu Saravanan, Jielin Zhang, Pieter G. Tepper, Erick Strauss and Gerrit J. Poelarends

Chemistry A European J, 2018, 24, 17434
DOI: 10.1002/chem.201804151

Apicomplexan mitochondrial metabolism: a story of gains, losses and retentions

Frank Seeber, Julien Limenitakis and Dominique Soldati-Favre

Trends in Parasitology, 2008, 24, 468
DOI: 10.1016/j.pt.2008.07.004

Growth Phase-Dependent Proteomes of the Malaysian IsolatedLactococcus lactisDairy Strain M4 Using Label-Free Qualitative Shotgun Proteomics Analysis

Theresa Wan Chen Yap, Amir Rabu, Farah Diba Abu Bakar, Raha Abdul Rahim, Nor Muhammad Mahadi, Rosli Md. Illias and Abdul Munir Abdul Murad

The Scientific World Journal, 2014, 2014, 1
DOI: 10.1155/2014/642891

Overproduction of D-pantothenic acid via fermentation conditions optimization and isoleucine feeding from recombinant Escherichia coli W3110

Shu-Ping Zou, Kuo Zhao, Zhi-Jian Wang, Bo Zhang, Zhi-Qiang Liu and Yu-Guo Zheng

3 Biotech, 2021, 11
DOI: 10.1007/s13205-021-02773-0

Recent advances in microbial production of nutraceuticals: a sustainable approach

Dong Zhang, Anying Ji, Ruixi Yu, Pengfei Jiang, Feiteng Sun and Ninghan Feng

3 Biotech, 2026, 16
DOI: 10.1007/s13205-025-04626-6

Integrating Fermentation Engineering and Organopalladium Chemocatalysis for the Production of Squalene from Biomass-Derived Carbohydrates as the Starting Material

Cuicui Wu, Kaifei Tian, Xuan Guo and Yunming Fang

Catalysts, 2023, 13, 1392
DOI: 10.3390/catal13111392

Atık Yılan Gömleğinin Taşıyıcı Sistem Olarak Değerlendirilmesi ve D-Panthenol’ün in Vitro Salımı

Betül AKTAŞ, Lalehan AKYÜZ and Murat KAYA

Aksaray University Journal of Science and Engineering, 2023, 7, 99
DOI: 10.29002/asujse.1298383

A d-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of Mycobacterium tuberculosis

Michael J. Pepi, Shibin Chacko, Gary M. Marqus, Vinayak Singh, Zhe Wang, Kyle Planck, Ryan T. Cullinane, Penchala N. Meka, Deviprasad R. Gollapalli, Thomas R. Ioerger, Kyu Y. Rhee, Gregory D. Cuny, Helena I.M. Boshoff and Lizbeth Hedstrom

ACS Infect. Dis., 2022, 8, 330
DOI: 10.1021/acsinfecdis.1c00461

Pantothenic Acid Biosynthesis in the Parasite Toxoplasma gondii: a Target for Chemotherapy

Sarmad N. Mageed, Fraser Cunningham, Alvin Wei Hung, Hernani Leonardo Silvestre, Shijun Wen, Tom L. Blundell, Chris Abell and Glenn A. McConkey

Antimicrob Agents Chemother, 2014, 58, 6345
DOI: 10.1128/AAC.02640-14

Biophysical tools to monitor enzyme–ligand interactions of enzymes involved in vitamin biosynthesis

A. Ciulli and C. Abell

Biochemical Society Transactions, 2005, 33, 767
DOI: 10.1042/BST0330767

Detecting subtle functional differences in ketopantoate reductase and related enzymes using a rule-based approach with sequence-structure homology recognition scores

S. Mondal, C. Nagao and K. Mizuguchi

Protein Engineering Design and Selection, 2010, 23, 859
DOI: 10.1093/protein/gzq062

Identification of mutations restricting autocatalytic activation of bacterial l-aspartate α-decarboxylase

Qin Mo, Youran Li, Junhua Wang and Guiyang Shi

Amino Acids, 2018, 50, 1433
DOI: 10.1007/s00726-018-2620-9

Inhibition of Mycobacterium tuberculosis Pantothenate Synthetase by Analogues of the Reaction Intermediate

Alessio Ciulli, Duncan E. Scott, Michiyo Ando, Fernando Reyes, S. Adrian Saldanha, Kellie L. Tuck, Dimitri Y. Chirgadze, Tom L. Blundell and Chris Abell

ChemBioChem, 2008, 9, 2606
DOI: 10.1002/cbic.200800437

Effects of high-voltage electrostatic field (HVEF) on frozen shrimp (Solenocera melantho) based on UPLC-MS untargeted metabolism

Jiao Liu, Feixia Zhu, Jing Yang, Yue Wang, Xiaohan Ma, Yongjiang Lou and Yongyong Li

Food Chemistry, 2023, 411, 135499
DOI: 10.1016/j.foodchem.2023.135499

Pantothenate biosynthesis in higher plants: advances and challenges

Ereck Chakauya, Katy M. Coxon, Heather M. Whitney, Jennifer L. Ashurst, Chris Abell and Alison G. Smith

Physiologia Plantarum, 2006, 126, 319
DOI: 10.1111/j.1399-3054.2006.00683.x

Pathway-Selective Sensitization of Mycobacterium tuberculosis for Target-Based Whole-Cell Screening

Garth L. Abrahams, Anuradha Kumar, Suzana Savvi, Alvin W. Hung, Shijun Wen, Chris Abell, Clifton E. Barry, David R. Sherman, Helena I.M. Boshoff and Valerie Mizrahi

Chemistry & Biology, 2012, 19, 844
DOI: 10.1016/j.chembiol.2012.05.020

The Structure of the PanD/PanZ Protein Complex Reveals Negative Feedback Regulation of Pantothenate Biosynthesis by Coenzyme A

Diana C.F. Monteiro, Vijay Patel, Christopher P. Bartlett, Shingo Nozaki, Thomas D. Grant, James A. Gowdy, Gary S. Thompson, Arnout P. Kalverda, Edward H. Snell, Hironori Niki, Arwen R. Pearson and Michael E. Webb

Chemistry & Biology, 2015, 22, 492
DOI: 10.1016/j.chembiol.2015.03.017

Fluorogenic Assay for Acetohydroxyacid Synthase: Design and Applications

Yonghui Xie, Changyu Zhang, Zhihua Wang, Chao Wei, Ningjing Liao, Xin Wen, Congwei Niu, Long Yi, Zejian Wang and Zhen Xi

Anal. Chem., 2019, 91, 13582
DOI: 10.1021/acs.analchem.9b02739

Backbone assignments of the 34 kDa ketopantoate reductase from E. coli

Stephen J. Headey, Amelia Vom, Jamie S. Simpson and Martin J. Scanlon

Biomol NMR Assign, 2008, 2, 93
DOI: 10.1007/s12104-008-9093-9

Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation

Julienne C. Kaiser, David E. Heinrichs and Danielle A. Garsin

mBio, 2018, 9
DOI: 10.1128/mBio.01188-18

In Vitro Reconstitution of the Pantothenic Acid Degradation Pathway in Ochrobactrum anthropi

Yuping Liu, Siting Pan, Xinshuai Zhang and Hua Huang

ACS Chem. Biol., 2021, 16, 1350
DOI: 10.1021/acschembio.1c00492

Combing with redox regulation via quorum-sensing system and fermentation strategies for improving D-pantothenic acid production

Hai-Bin Qin, Jun-Ping Zhou, Bo Zhang, Zhi-Qiang Liu and Yu-Guo Zheng

Process Biochemistry, 2022, 121, 681
DOI: 10.1016/j.procbio.2022.08.012