Pengkun Sun, Cunzheng Fan, Nian Liu, Minghui Tong, Xuan Shi, Han Wang, Shuyi Mu, Ningyuan Hu, Yixiang Sun, Haoyu Zhang, Zixuan Gao, Dongmei Zhao and Maosheng Cheng
RSC Med. Chem., 2025,16, 3551-3566
From themed collection:
Highlights from Industry
Abstract
PLK4 is a serine/threonine protein kinase situated at the centrosome, acting as a crucial regulatory element in the regulation of cell mitosis and significantly contributing to the preservation of genomic integrity.
Yanli Xue, Shuyi Mu, Pengkun Sun, Yin Sun, Nian Liu, Yu Sun, Lin Wang, Dongmei Zhao and Maosheng Cheng
RSC Med. Chem., 2023,14, 1787-1802
Abstract
A structurally novel and highly efficient PLK4 inhibitor was synthesized.
Shuyi Mu, Wenqiang Sun, Zehui Qi, Minghui Tong, Xuan Shi, Han Wang, Nian Liu, Pengkun Sun, Cunzheng Fan, Ningyuan Hu, Yixiang Sun, Haoyu Zhang, Zixuan Gao, Dongmei Zhao and Maosheng Cheng
RSC Med. Chem., 2025,16, 4997-5011
Abstract
Serine/threonine kinase PLK4, a critical regulator of centrosome duplication, is closely associated with tumorigenesis due to its role in centrosome amplification.
Nian Liu, Xin Wang, Qinglin Fu, Qiaohua Qin, Tianxiao Wu, Ruicheng Lv, Dongmei Zhao and Maosheng Cheng
RSC Med. Chem., 2023,14, 85-102
Abstract
Based on scaffold hopping and computer-aid drug design, 38 pyrazolo[3,4-b]pyridine derivatives were synthesised. Among them, compound C03 showed acceptable activity with an IC50 value of 56 nM to TRKA kinase.
Shekar Mekala, You Wu and Yue-Ming Li
RSC Med. Chem., 2025,16, 605-639
Abstract
Advances in the positron emission tomography (PET) tracer development for imaging of tau in Alzheimer's disease (AD) and non-AD, and for imaging of α-synuclein in Parkinson's disease (PD).