This study aimed to synthesize symmetrical phenylamino-s-triazine derivatives with one aromatic amine and two hexagonal saturated cyclic amines and evaluate their anticancer activity. The potential derivatives have been investigated in silico.
Here, we look at recent efforts towards the discovery and optimisation of small-molecules targeting the constellation of mitotic kinases for the treatment of pancreatic cancer.
Endocytosis efficiency is a prerequisite for the therapeutic efficacy of nanoparticle-based cancer therapy. This review elucidates the physicochemical design, anti-cancer effects and endocytic mechanism of multiple endocytosis-oriented nanoparticles.
Purines as precursor pharmacophores in chemical reactions.
In response to the urgent need for new anti-proliferative agents, four novel series of triazolopyrimidine compounds (7a–e, 9a–d, 11a–f, and 13a–e) were synthesized and evaluated for in vitro and in vivo anticancer efficacy.