Developments in the synthesis of indolizines during the last decade are reviewed, with special emphasis given to strategies relying on pyrrole derivatives and on π-expanded systems.
An efficient synthesis of azepino- and azocino[1,2-a]indoles from isatin derivatives is described via allyl-metal addition, 1,2-allyl migration, ring-closing metathesis, and acid-catalyzed aromatization.
This review summarizes the synthetic advancements for the construction of polycyclic fused indole scaffolds from easily accessible indole-2-carboxamide derivatives as a valuable synthetic precursor.
We report a formal [3 + 2] cycloaddition for constructing 3-aryl pyrido[1,2-a]indoles from aryne intermediates and 2-pyridinyl-substituted p-QMs under ambient conditions.
Starting from 2-halopyridines and ester (Z)-3-amino-3-arylacrylates, one-pot tandem syntheses of diverse pyrido[1,2-a]pyrimidin-4-ones have been established via CuI-catalyzed Ullmann-type C–N bond formation/intramolecular amidation reaction.