Novel guanidines are synthesized as DNA minor groove binders. Spectroscopic and DFT studies revealed that EDGs synergize with halogens to enhance binding affinity, offering promising scaffolds for anticancer drug design.
The promising in vitro and in vivo efficacy, combined with favorable biosafety, positions zinc(II) N-cyclohexyl N-(4-methylbenzyl) dithiocarbamate complexes as potential candidates for anti-lymphoma therapies.
Trimethoxy derivatives 5f (IC50 = 1.50 μM) and 6f (IC50 = 1.15 μM) demonstrated higher COX-2 inhibitory activity than celecoxib. Also, they showed the highest inhibition of NO, TNF-α, IL-6, and PGE-2 production in LPS-induced RAW264.7 macrophages.
Isatin (1H-indole-2,3-dione) is a privileged nitrogen-containing heterocyclic framework that has received considerable attention in anticancer drug discovery owing to its diverse biological behavior and structural modifications.
The excellent catalytic activity of newly magnetic nanocatalyst FeAl2O4@PTMS-sulfaguanidine-SA in a one pot multicomponent Mannich-type reaction was used to obtain 2-piperazinyl quinoxaline derivatives with highly selective anti-proliferation efficacy.