This review summarizes recent progress in artificial receptors with superior glycan recognition ability and their applications in virus neutralizing, cancer diagnostics and targeted therapeutics.
(a) Two primary mechanisms for cross-presentation of internalized antigens: cytosolic and vacuolar pathways. (b) To enhance antigen presentation and generate T cell responses, glycans are multivalently presented on a range of nanocarrier systems.
This review highlights the recent development in the use of carriers of increasing simplicities and versatile chemical ligation processes leading to synthetic vaccine candidates against tumor-associated carbohydrate antigens (TACAs).
This review surveys glycans as biomarkers and challenges in using glycan-binding receptors for cancer diagnosis. We highlight merits, applications, and future directions of using molecularly imprinted polymers as effective glycan-binding receptors.
An efficient chemoenzymatic strategy to rapidly assemble diverse sulfated and sialylated CD34 O-glycopeptides reveals glycan-directed molecular recognition.