The phytase RipBL1 enables the assignment of a specific inositol phosphate isomer as a structural component of human kidney stones

Guizhen Liu, Esther Riemer, Robin Schneider, Daniela Cabuzu, Olivier Bonny, Carsten A. Wagner, Danye Qiu, Adolfo Saiardi, Annett Strauss, Thomas Lahaye, Gabriel Schaaf, Thomas Knoll, Jan P. Jessen and Henning J. Jessen

RSC Chem. Biol., 2023, 4, 300
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The inositol phosphate signalling network in physiology and disease

Seyun Kim, Rashna Bhandari, Charles A. Brearley and Adolfo Saiardi

Trends in Biochemical Sciences, 2024, 49, 969
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The wheat VIH2-3B, a functional PPIP5K controls the localization of fasciclin-like arabinogalactan protein

Anuj Shukla, Reshma Gopal, Riya Ghosh, Ankur Chaudhuri, Kanupriya Agrwal, Rahul Tanwar, Henning Jacob Jessen, Debabrata Laha and Ajay Kumar Pandey

Advances in Biological Regulation, 2025, 97, 101103
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Neue Werkzeuge für die Inositolpyrophosphat‐Forschung: Stereoselektive Synthese und Einsatz von PP‐InsP₄‐Isomeren in der Pflanzenforschung

Kevin Ritter, Anne‐Sophie C. Braun, Guizhen Liu, Mengsi Lu, Verena Gaugler, Gabriel Schaaf and Henning Jacob Jessen

Angewandte Chemie, 2025, 137
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Assigning the Absolute Configuration of Inositol Poly- and Pyrophosphates by NMR Using a Single Chiral Solvating Agent

Kevin Ritter, Nikolaus Jork, Anne-Sophie Unmüßig, Maja Köhn and Henning J. Jessen

Biomolecules, 2023, 13, 1150
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Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol

Samuel Bru, Lydie Michaillat Mayer, Geun-Don Kim, Danye Qiu, Henning J Jessen and Andreas Mayer

eLife, 2025, 14
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Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis

Hongyun Zhang, Bobo Zhang, Yuebo Zhao, Yang Su, Yifan Peng, Xiaoli Yang, Hongming Zhao, Hongyu Liu, Jie Feng, Hongjing Pei, Wenyong Zhang, Niu Huang, Kai Jiang, Masatoshi Ito, Guizhen Liu, Nicolas Jork, Karen E. Anderson, Li Zhao, Eiichiro Nagata, Henning J. Jessen, Philip T. Hawkins, Changzheng Du and Feng Rao

Nat Chem Biol, 2026, 22, 293
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NUDIX hydrolases target specific inositol pyrophosphates and regulate phosphate homeostasis and bacterial pathogen susceptibility in Arabidopsis

Robin Schneider, Klea Lami, Isabel Prucker, Sara Christina Stolze, Annett Strauß, Julie Marie Schmidt, Simon M. Bartsch, Kevin Langenbach, Esther Lange, Kevin Ritter, David Furkert, Natalie Faiß, Sandeep Kumar, M. Shamim Hasan, Athanasios Makris, Lukas Krusenbaum, Stefanie Wege, Yemisrach Zewdu Belay, Simon Kriescher, Jeremy The, Michael Harings, Florian M. W. Grundler, Martina K. Ried‐Lasi, Heiko Schoof, Philipp Gaugler, Marília Kamleitner, Dorothea Fiedler, Hirofumi Nakagami, Ricardo F. H. Giehl, Thomas Lahaye, Saikat Bhattacharjee, Henning J. Jessen, Verena Gaugler and Gabriel Schaaf

JIPB, 2025, 67, 3123
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Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81

Valentin Chabert, Geun-Don Kim, Danye Qiu, Guizhen Liu, Lydie Michaillat Mayer, Muhammed Jamsheer K, Henning J Jessen and Andreas Mayer

eLife, 2023, 12
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A Comprehensive Review on Capillary Electrophoresis–Mass Spectrometry in Advancing Biomolecular Research

Laura Pont, María Vergara‐Barberán and Enrique Javier Carrasco‐Correa

Electrophoresis, 2025, 46, 1053
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Synthesis of a New Purine Analogue Class with Antifungal Activity and Improved Potency against Fungal IP3–4K

Desmarini Desmarini, Daniel Truong, Pooja Sethiya, Guizhen Liu, Bethany Bowring, Henning Jessen, Hue Dinh, Amy K. Cain, Philip E. Thompson and Julianne T. Djordjevic

ACS Infect. Dis., 2025, 11, 940
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Inositol pyrophosphate kinases in health and disease

Changchang Xing, Chao Wang, Yuanyuan Chen, Weiwei Cheng, Zhaolei Jiang, Alex F. Chen and Chenglai Fu

FEBS Letters, 2025
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Ultrasensitive Electrochemical Detection of Myo‑Inositol in Gestational Diabetes Mellitus Urine Using Poly-Eriochrome Black T Modified Glassy Carbon Electrode

Lingyi Huang, Chunyan Liu, Wanrong Chen, Kun Yang, Jing Yu and Yanjie Zheng

J. Electrochem. Soc., 2026, 173, 076501
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Arg1 from Cryptococcus neoformans lacks PI3 kinase activity and conveys virulence roles via its IP 3-4 kinase activity

Desmarini Desmarini, Guizhen Liu, Henning Jessen, Bethany Bowring, Angela Connolly, Ben Crossett, Julianne Teresa Djordjevic and J. Andrew Alspaugh

mBio, 2024, 15
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Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development

Florian Laurent, Simon M. Bartsch, Anuj Shukla, Felix Rico-Resendiz, Daniel Couto, Christelle Fuchs, Joël Nicolet, Sylvain Loubéry, Henning J. Jessen, Dorothea Fiedler, Michael Hothorn and Caroline Gutjahr

PLoS Genet, 2024, 20, e1011468
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Measuring phytic acid in complex and fermented food matrices: Modified protocol using enzymatic analysis

Neda Rousta and Mohammad J. Taherzadeh

JSFA Reports, 2026, 6, 4
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Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi

Mayara S. Bertolini, Sabrina E. Cline, Miguel A. Chiurillo, Brian S. Mantilla, Aharon Eidex, Logan P. Crowe, Danye Qiu, Henning J. Jessen, Adolfo Saiardi, Roberto Docampo, L. David Sibley and Igor C. Almeida

mBio, 2025, 16
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Transport and InsP8 gating mechanisms of the human inorganic phosphate exporter XPR1

Qinyu Zhu, Madeleine F. Yaggi, Nikolaus Jork, Henning J. Jessen and Melinda M. Diver

Nat Commun, 2025, 16
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Expanding the Inositol Pyrophosphate Toolbox: Stereoselective Synthesis and Application of PP‐InsP4 Isomers in Plant Signaling

Kevin Ritter, Anne‐Sophie C. Braun, Guizhen Liu, Mengsi Lu, Verena Gaugler, Gabriel Schaaf and Henning Jacob Jessen

Angew Chem Int Ed, 2025, 64
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Analytical methods and tools for studying inositol phosphates

Masatoshi Ito, Shinichi Koguchi, Adolfo Saiardi and Eiichiro Nagata

FEBS Letters, 2025
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Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast

Beate Schwer, Isabel Prucker, Ana M. Sanchez, Jill Babor, Henning J. Jessen, Stewart Shuman and Fred M. Winston

mBio, 2025, 16
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Elevation of inositol pyrophosphate IP7 in the mammalian spinal cord of amyotrophic lateral sclerosis

Masatoshi Ito, Natsuko Fujii, Saori Kohara, Masayuki Tanaka, Masaki Takao, Ban Mihara, Yuko Saito, Atsushi Mizuma, Taira Nakayama, Shizuka Netsu, Naoto Suzuki, Akiyoshi Kakita and Eiichiro Nagata

Front. Neurol., 2024, 14
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Inositol Pyrophosphates as Versatile Metabolic Messengers

Latika Nagpal, Sining He, Feng Rao and Solomon H. Snyder

Annual Review of Biochemistry, 2024, 93, 317
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Pools of Independently Cycling Inositol Phosphates Revealed by Pulse Labeling with 18O-Water

Geun-Don Kim, Guizhen Liu, Danye Qiu, Maria Giovanna De Leo, Navin Gopaldass, Jacques Hermes, Jens Timmer, Adolfo Saiardi, Andreas Mayer and Henning Jacob Jessen

J. Am. Chem. Soc., 2025, 147, 17626
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The expanding landscape of inositol phosphate signaling network in land plants

Riya Ghosh, Ranjana Yadav, Naga Jyothi Pullagurla, Priyanshi Rana and Debabrata Laha

FEBS Letters, 2025
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Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81

Valentin Chabert, Geun-Don Kim, Danye Qiu, Guizhen Liu, Lydie Michaillat Mayer, Muhammed Jamsheer K, Henning J Jessen and Andreas Mayer

eLife, 2023, 12
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Establishing 18O-Labeled Inositol Phosphates for Quantitative Capillary Electrophoresis-Mass Spectrometry: Fragmentation Pathways and Comparison with 13C-Labeled Analogs

Guizhen Liu, Tobias Dürr-Mayer, Mengsi Lu and Henning J. Jessen

Anal. Chem., 2025, 97, 25282
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Differentiation of Cis/trans-geometrical isomers in long-chain unsaturated fatty acids based on ion mobility and theoretical calculations

Sisi He, Lulu Shi, Zi-Wei Zheng, Fangling Wu and Chuan-Fan Ding

Food Chemistry, 2024, 457, 140156
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Identification and Characterization of a Blood–Brain Barrier Penetrant Inositol Hexakisphosphate Kinase (IP6K) Inhibitor

Tyler Heitmann, Gangling Liao, Glen Ernst, Michael Poslusney, Thomas van Kralingen, Ye Li, Megan Masi, Michael DePasquale, Ingrid Buchler, Huijun Wei, Gregory V. Carr, Evgeny Shlevkov, Mengsi Lu, Henning Jessen and James C. Barrow

J. Med. Chem., 2024, 67, 13639
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Protein pyrophosphorylation by inositol phosphates: a novel post-translational modification in plants?

Yeshambel Emewodih Mihiret, Gabriel Schaaf and Marília Kamleitner

Front. Plant Sci., 2024, 15
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Conservation of heat stress acclimation by the IPK2-type kinases that control the synthesis of the inositol pyrophosphate 4/6-InsP7 in land plants

Ranjana Yadav, Guizhen Liu, Priyanshi Rana, Naga Jyothi Pullagurla, Danye Qiu, Henning J. Jessen, Debabrata Laha and Bao-Cai Tan

PLoS Genet, 2025, 21, e1011838
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A linear pathway for inositol pyrophosphate metabolism revealed by 18O labeling and model reduction

Jacques Hermes, Geun-Don Kim, Guizhen Liu, Maria Giovanna De Leo, Andreas Mayer, Henning Jessen, Jens Timmer and Marc R. Birtwistle

PLoS Comput Biol, 2025, 21, e1013680
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The ring rules the chain — inositol pyrophosphates and the regulation of inorganic polyphosphate

Azmi Khan, Manisha Mallick, Jayashree S. Ladke and Rashna Bhandari

Biochemical Society Transactions, 2024, 52, 567
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Metabolism of inositol derivatives by the gut microbiome

Henning Jessen and Thi Phuong Nam Bui

Gut Microbes, 2025, 17
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The role of metabolomics in informing strategies for improving photosynthesis

Philipp Westhoff, Andreas P M Weber and Yonghua Li-Beisson

Journal of Experimental Botany, 2024, 75, 1696
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Biochemical and biophysical characterization of inositol-tetrakisphosphate 1-kinase inhibitors

Martin Y. Ng, Huanchen Wang, Haibo Zhang, Isabel Prucker, Lalith Perera, Ekaterina Goncharova, Antony Wamiru, Henning J. Jessen, Robin E. Stanley, Stephen B. Shears, Ji Luo, Barry R. O'Keefe and Brice A.P. Wilson

Journal of Biological Chemistry, 2025, 301, 108274
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Affinity‐Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6‐PP‐InsP5‐Binding Proteins in Plants

Kevin Ritter, Verena Gaugler, Sara Christina Stolze, Riya Ghosh, Akhila Jayamon, Ranjana Yadav, Felix Wollensack, Debabrata Laha, Hirofumi Nakagami, Gabriel Schaaf and Henning Jacob Jessen

Advanced Science, 2026
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Orchestration of phosphate homeostasis by the ITPK1-type inositol phosphate kinase in the liverwort Marchantia polymorpha

Naga Jyothi Pullagurla, Supritam Shome, Guizhen Liu, Henning J Jessen and Debabrata Laha

Plant Physiology, 2025, 197
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Bacterial Pathogen Infection Triggers Magic Spot Nucleotide Signaling in Arabidopsis thaliana Chloroplasts through Specific RelA/SpoT Homologues

Danye Qiu, Esther Lange, Thomas M. Haas, Isabel Prucker, Shinji Masuda, Yan L. Wang, Georg Felix, Gabriel Schaaf and Henning J. Jessen

J. Am. Chem. Soc., 2023, 145, 16081
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Phosphorus-specific, liquid chromatography inductively coupled plasma mass spectrometry for analysis of inositol phosphate and inositol pyrophosphate metabolism

Colleen Sprigg, Hayley L. Whitfield, Philip T. Leftwich, Hui-Fen Kuo, Tzyy-Jen Chiou, Adolfo Saiardi, Megan L. Shipton, Andrew M. Riley, Barry V.L. Potter, Dawn Scholey, Emily Burton, Mike R. Bedford and Charles A. Brearley

Biochemical Journal, 2025, 482, 1627
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β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner

Verena B. Eisenbeis, Danye Qiu, Oliver Gorka, Lisa Strotmann, Guizhen Liu, Isabel Prucker, Xue Bessie Su, Miranda S. C. Wilson, Kevin Ritter, Christoph Loenarz, Olaf Groß, Adolfo Saiardi and Henning J. Jessen

Proc. Natl. Acad. Sci. U.S.A., 2023, 120
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Functions, Mechanisms, and therapeutic applications of the inositol pyrophosphates 5PP-InsP5 and InsP8 in mammalian cells

Ji Qi, Linhui Shi, Limei Zhu, Yuanyuan Chen, Hong Zhu, Weiwei Cheng, Alex F. Chen and Chenglai Fu

J. of Cardiovasc. Trans. Res., 2024, 17, 197
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