The application of natural product-delivering micro/nano systems in the treatment of inflammatory bowel disease

Yixuan Zhou, Xingxing Feng, Hongbo Xu, Jing Guo, Conglian Yang, Li Kong and Zhiping Zhang

J. Mater. Chem. B, 2023, 11, 244
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Oral bomb effect nanotherapeutics alleviate ulcerative colitis through coordinated anti-inflammatory and pro-resolving strategies

Mei Yang, Yuanyuan Zhu, Xiaodan Wei, Jinteng Feng, Yingli He, Jue Jiang, Qi Zhou, Mingzhen Zhang, Guangjian Zhang and Wenqi Ma

Biomater. Sci., 2024, 12, 5386
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Orally-administered nanomedicine systems targeting colon inflammation for the treatment of inflammatory bowel disease: latest advances

Shumeng Hu, Runan Zhao, Yu Xu, Zelin Gu, Beiwei Zhu and Jiangning Hu

J. Mater. Chem. B, 2024, 12, 13
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Bioinspired and biomimetic strategies for inflammatory bowel disease therapy

Limei Zhang, Peng Ye, Huatai Zhu, Liyu Zhu, Yuting Ren and Jiandu Lei

J. Mater. Chem. B, 2024, 12, 3614
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κ-Selenocarrageenan Oligosaccharides Prepared by Deep-Sea Enzyme Alleviate Inflammatory Responses and Modulate Gut Microbiota in Ulcerative Colitis Mice

Kai Wang, Ling Qin, Junhan Cao, Liping Zhang, Ming Liu, Changfeng Qu and Jinlai Miao

IJMS, 2023, 24, 4672
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Oral Administration of Platinum Nanoparticles with SOD/CAT Cascade Catalytic Activity to Alleviate Ulcerative Colitis

Hao Liu, Yujie Zhang, Mingzhen Zhang, Zhaoxiang Yu and Mingxin Zhang

JFB, 2023, 14, 548
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Oral Nanotherapeutics of Andrographolide/Carbon Monoxide Donor for Synergistically Anti-inflammatory and Pro-resolving Treatment of Ulcerative Colitis

Ying Zhou, Mei Yang, Xiangji Yan, Lingmin Zhang, Ning Lu, Yana Ma, Yuanyuan Zhang, Manli Cui, Mingzhen Zhang and Mingxin Zhang

ACS Appl. Mater. Interfaces, 2023, 15, 36061
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An intratumor bacteria-targeted DNA nanocarrier for multifaceted tumor microenvironment intervention

Yibiao Wang, Xiaomei Fu, Yang Zhu, Mingjing Lin, Renduan Cai, Yang Zhu and Tiantian Wu

Materials Today Bio, 2024, 27, 101144
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Plant-Based Nano-Delivery Systems in the Treatment of Inflammatory Disorders

Catarina R. Silva, Amélia C. F. Vieira, Ana Cláudia Paiva-Santos, Francisco Veiga and Gustavo Costa

Pharmaceutics, 2026, 18, 150
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Gelatin-Based Electrospun Nanofibers Cross-Linked Using Horseradish Peroxidase for Plasmid DNA Delivery

Kotoko Furuno, Keiichiro Suzuki and Shinji Sakai

Biomolecules, 2022, 12, 1638
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Bio-adhesive and ROS-scavenging hydrogel microspheres for targeted ulcerative colitis therapy

Qiqi Sun, Jun Chen, Quan Zhao, Ziyun He, Lei Tang, Yuji Pu and Bin He

International Journal of Pharmaceutics, 2023, 639, 122962
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Hyaluronic acid-functionalized DDAB/PLGA nanoparticles for improved oral delivery of magnolol in the treatment of ulcerative colitis

Wei Li, Jie Lin, Jie Zhou, Siqi He, Anqi Wang, Yingfan Hu, Hanmei Li, Liang Zou and Ya Liu

International Journal of Pharmaceutics, 2024, 653, 123878
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Recent progress on engineered micro/nanomaterials mediated modulation of gut microbiota for treating inflammatory bowel disease

Lingling Kan, Ziwen Zheng, Wanyue Fu, Yan Ma, Wanni Wang, Haisheng Qian and Lingling Xu

Journal of Controlled Release, 2024, 370, 43
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Chitosan nanovectors for siRNA delivery: New horizons for nonviral gene therapy

Mahdi Rahimi, Zahra Kariminezhad, Elsa-Patricia Rondon, Hassan Fahmi, Julio C. Fernandes and Mohamed Benderdour

Carbohydrate Polymers, 2025, 360, 123581
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Explore the underlying oral efficacy of α-, β-, γ-Cyclodextrin against the ulcerative colitis using in vitro and in vivo studies assisted by network pharmacology

Weiqin Wang, Xuefeng Li, Hangyi Wu, Fanli Shi, Zhenhai Zhang and Huixia Lv

Journal of Biomolecular Structure and Dynamics, 2024, 42, 4985
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Classical prescription Huanglian Decoction relieves ulcerative colitis via maintaining intestinal barrier integrity and modulating gut microbiota

Wei Hao, Zhejie Chen, Liju Wang, Qin Yuan, Caifang Gao, Meiling Ma, Congsheng Liu, Yitao Wang and Shengpeng Wang

Phytomedicine, 2022, 107, 154468
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Recent developments and new directions in the use of natural products for the treatment of inflammatory bowel disease

Yaqian Feng, Mengting Pan, Ruiqiong Li, Weishen He, Yangyang Chen, Shaohua Xu, Hui Chen, Huilong Xu and Yao Lin

Phytomedicine, 2024, 132, 155812
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Pharmacological effects of berberine on models of ulcerative colitis: A meta-analysis and systematic review of animal studies

Shuangyuan Hu, Pengfei Wei, Wei Li, Qingsong Liu, Shuanglan Chen, Caiyu Hu, Xiaochuan Guo, Xiao Ma, Jinhao Zeng and Yi Zhang

Front. Pharmacol., 2022, 13
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Nanotechnology-based drug delivery system for targeted therapy of ulcerative colitis from traditional Chinese medicine: A review

Chengcheng Gao, Zerun Yang, Ruirui Song, Huagang Sheng and Liqiao Zhu

International Journal of Pharmaceutics, 2025, 673, 125375
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CaGA nanozymes inhibit oxidative stress and protect mitochondrial function in ulcerative colitis therapy

Liting Lin, Qingrong Li, Yan Yang, Cong Zhang, Wenqi Wang, Fan Ni and Xianwen Wang

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Anti‐Oxidative and Anti‐Inflammatory Micelles: Break the Dry Eye Vicious Cycle

Su Li, Zhouyu Lu, Yue Huang, Yin Wang, Qiao Jin, Xingchao Shentu, Juan Ye, Jian Ji, Ke Yao and Haijie Han

Advanced Science, 2022, 9
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Engineered hydrogels for siRNA delivery: From smart design to therapeutic impact

Shaohui Geng, Yijin Jiang, Huawei Wang, Anqi Liu, Xiuwen Wang, Ran Man, Jingyuan Fu, Yiwei Guan, Zi Ye, Zixuan Shu, Han Sheng, Jinian Wei, Xinyu Wang, Xiao Tang, Xuemei Huang, Penglong Wang and Guangrui Huang

Chemical Engineering Journal, 2026, 527, 171852
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EUK nanozyme-loaded PL&GA coacervate droplets attenuate ulcerative colitis through restoring gut homeostasis and restricting intestinal cell ferroptosis

Mingxia Zhou, Linping Lu, Xinyu Xu, Yefan Zhou, Huan Fang, Xue Wang, Dongxu Li, Xiaoyan Li, Jiaqi Hua, Jiahe Liu, Yingxia Li, Libin Jiang, Qiuju Miao, Hongtao Wen, Jing He and Shenyu Yang

Materials Today Bio, 2025, 35, 102466
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Recognizing the biological barriers and pathophysiological characteristics of the gastrointestinal tract for the design and application of nanotherapeutics

Shan Li, Tianyu Wu, Jingfeng Wu, Wensheng Chen and Dinglin Zhang

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Advances in carbohydrate-based nanoparticles for targeted therapy of inflammatory bowel diseases: A review

Wenjing Liang, Wen Zhang, Jiayi Tian, Xinping Zhang, Xinyi Lv, Ao Qu, Jinyu Chen and Zijian Wu

International Journal of Biological Macromolecules, 2024, 281, 136392
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Interactions between Nanoparticles and Intestine

Manuela Vitulo, Elisa Gnodi, Raffaella Meneveri and Donatella Barisani

IJMS, 2022, 23, 4339
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Polycatechol-Derived Mesoporous Polydopamine Nanoparticles for Combined ROS Scavenging and Gene Interference Therapy in Inflammatory Bowel Disease

Liucan Wang, Zhenqiang Wang, Yiyang Pan, Shuaishuai Chen, Xin Fan, Xiaolong Li, Guoqing Chen, Yuanhang Ma, Yujiao Cai, Jixi Zhang, Hua Yang, Weidong Xiao and Min Yu

ACS Appl. Mater. Interfaces, 2022, 14, 19975
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Recent advances on emerging nanomaterials for diagnosis and treatment of inflammatory bowel disease

Wanyue Fu, Lingling Xu, Zetong Chen, Lingling Kan, Yan Ma, Haisheng Qian and Wanni Wang

Journal of Controlled Release, 2023, 363, 149
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Oral administration of Huanglian-Houpo herbal nanoemulsion loading multiple phytochemicals for ulcerative colitis therapy in mice

Xiao Wang, Li Fu, Weijian Cheng, Jiamei Chen, Huan Zhang, Huanjun Zhu, Chen Zhang, Chaomei Fu, Yichen Hu and Jinming Zhang

Drug Delivery, 2023, 30
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Nanomedicine for colon-targeted drug delivery: strategies focusing on inflammatory bowel disease and colon cancer

Ankaj Kumar, Klaudi K Vaiphei, Naveen Singh, Sri Pada Datta Chigurupati, Shivani Rai Paliwal, Rishi Paliwal and Arvind Gulbake

Nanomedicine, 2024, 19, 1347
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Emerging drug delivery systems with traditional routes – A roadmap to chronic inflammatory diseases

Kiyoon Min, Abhishek Sahu, Sae Hyun Jeon and Giyoong Tae

Advanced Drug Delivery Reviews, 2023, 203, 115119
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The development of nanocarriers for natural products

Liying Huang, Shicui Luo, Sen Tong, Zhuo Lv and Junzi Wu

WIREs Nanomed Nanobiotechnol, 2024, 16
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The Quasipaa spinosa skin peptide GFGFGGF prevents dextran sodium sulfate‐induced colitis by improving the intestinal barrier and gut microbiota

Yingjian Su, Yang Gao, Lingyu Zhang, Zhengxiao Zhang, Guiling Li, Changyi Zhou, Dejin Su, Jian Li and Daren Wu

J Sci Food Agric, 2025, 105, 7743
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Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery

Lingxiao Xu, Zhenxuan Shao, Xia Fang, Zengfeng Xin, Shenzhi Zhao, Hongbo Zhang, Yu Zhang, Wenbiao Zheng, Xiaohua Yu, Zengjie Zhang and Lingling Sun

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Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition

Yu-Ping Fu, Cen-Yu Li, Xi Peng, Helle Wangensteen, Kari Tvete Inngjerdingen and Yuan-Feng Zou

Biomedicine & Pharmacotherapy, 2022, 155, 113767
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Orally administration of cerium oxide nanozyme for computed tomography imaging and anti-inflammatory/anti-fibrotic therapy of inflammatory bowel disease

Yameng Cao, Kai Cheng, Mei Yang, Zhichao Deng, Yana Ma, Xiangji Yan, Yuanyuan Zhang, Zhenzhen Jia, Jun Wang, Kangsheng Tu, Jie Liang and Mingzhen Zhang

J Nanobiotechnol, 2023, 21
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Next-generation nanocarriers for therapeutic oligonucleotides: Precision targeting and stimuli-responsive cancer therapy

Yantong Li, Mei Zhang, Junjie Gu, Yao He, Mi Zhou and Yunfeng Lin

Pharmacology & Therapeutics, 2026, 277, 108960
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Pulmonary RNA interference against acute lung injury mediated by mucus- and cell-penetrating nanocomplexes

Wenxin Zhang, Jingrui Shen, Jialong Liang, Chenglong Ge, Yang Zhou, Lichen Yin and Yong Ji

Acta Biomaterialia, 2024, 177, 332
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New targets for the treatment of ulcerative colitis: Gut microbiota and its metabolites

Huanyu Li, Meng Pan, Yifan Li, Manli Cui and Mingxin Zhang

Comput Struct Biotechnol J, 2025, 27, 1850
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Colon‐Targeted Natural Polysaccharide‐Berberine Armored Hydrogel for the Treatment of Colitis

Miao Guo, Bo Li, Hongyi Li, Yi Chen, Qin Yuan, Mingju Shui, Hefeng Zhou, Wei Hao and Shengpeng Wang

Adv Healthcare Materials, 2025, 14
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Efficacy and safety of berberine plus 5-ASA for ulcerative colitis: A systematic review and meta-analysis

Jilei Li, Chenchen Zhang, Yanchao Xu, Lili Yang and Nicholas A. Pullen

PLoS ONE, 2024, 19, e0309144
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Colon-targeted delivery of polyphenols: construction principles, targeting mechanisms and evaluation methods

Yidi Wang, Zhiying Li, Yiwen Bao, Huijun Cui, Jiaxin Li, Baoge Song, Mengzhu Wang, Haikun Li, Xingyue Cui, Yi Chen, Wei Chen, Shufang Yang, Yiyun Yang, Zhufeng Jin, Xu Si and Bin Li

Critical Reviews in Food Science and Nutrition, 2025, 65, 64
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Polyphenol Carrier-Enhanced Curcumin Nanoparticles for Targeted, Synergic Therapy of Inflammatory Bowel Disease: Self-Adaptive Modulation of Mitochondrial Homeostasis and Immune Response

Danni Liu, Xiangyu Chen, Qiulan Tong, Jianmin Jiang, Lei Ma, Yunfei Tan, Xingwu Ran, Xudong Li and Zeng Yi

ACS Appl. Mater. Interfaces, 2025
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Berberine prevents NAFLD and HCC by modulating metabolic disorders

Xinyue Lin, Juanhong Zhang, Yajun Chu, Qiuying Nie and Junmin Zhang

Pharmacology & Therapeutics, 2024, 254, 108593
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