Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice

Shiwei Yao, Hongling Lu, Tianhuan Zhou, Qihong Jiang, Chenkai Jiang, Wenjun Hu, Mingqian Li, Chin Ping Tan, Yongcai Feng, Qun Du, Guoxin Shen, Xingwei Xiang and Lin Chen

Food Funct., 2024, 15, 4490
DOI: 10.1039/D3FO04527G

Obesity, but not high-fat diet, is associated with bone loss that is reversed via CD4+CD25+Foxp3+ Tregs-mediated gut microbiome of non-obese mice

Wei Song, Qinglin Sheng, Yuying Bai, Li Li, Xin Ning, Yangeng Liu, Chen Song, Tianyi Wang, Xiaohua Dong, Yane Luo, Jinhong Hu, Lina Zhu, Xiaole Cui, Bing Chen, Lingling Li, Congli Cai, Haobo Cui and Tianli Yue

npj Sci Food, 2023, 7
DOI: 10.1038/s41538-023-00190-6

Effects of high fat diet on blood lipids and liver enzymes in murine model: the systemic and experimental study

Thuy-Duong Vu, Anh-Dao Ngo, Son-Tung Nguyen, Yen-Nhi Khuong, Van-Bao Phan, Tien-Dat Pham, Duc-Anh Le, Thanh-Thuy To, Chia-Ching Wu and Dinh-Toi Chu

Obesity Medicine, 2025, 55, 100614
DOI: 10.1016/j.obmed.2025.100614

The contested association between MASLD and osteoporosis: a narrative review of heterogeneous evidence and modifying factors

Ya-Jun Xiao, Yan-Ling Zhang, Xiao-Zhou Mao, Di Yang, Yan-Qun Liu, Yan Cheng, Xiao-Ling Liu, Chang-Feng Sun, Hao Sun and Cun-Liang Deng

Arch Osteoporos, 2026, 21
DOI: 10.1007/s11657-025-01639-9

Impact of leptin deficiency on male tibia and vertebral body 3D bone architecture independent of changes in body weight

Alexander Williamson, Alexandre da Silva, Jussara M. do Carmo, Christine L. Le Maitre, John E. Hall and Nicola Aberdein

Physiological Reports, 2023, 11
DOI: 10.14814/phy2.15832

The associations between body fat distribution and bone mineral density in the Oxford Biobank: a cross sectional study

Catriona Hilton, Senthil K Vasan, Matt J Neville, Constantinos Christodoulides and Fredrik Karpe

Expert Review of Endocrinology & Metabolism, 2022, 17, 75
DOI: 10.1080/17446651.2022.2008238

The impact of obesity on bone health: molecular pathways, metabolic interactions, and associated pathologies

Abolfazl Bagherifard, Ahmad Hemmatyar, Karo Khosravi, Ali Rouzbahani, Khatere Mokhtari, Hooman Yahyazedeh and Hamid Tanzadehpanah

Int J Obes, 2026, 50, 87
DOI: 10.1038/s41366-025-01907-1

Effects of a high‐fat diet on gut microbiota and possible implications for bone health in male Wistar rats

Fernanda Guedes Rodrigues, Milene Subtil Ormanji, Renata Meca, Horácio Montenegro, Lilian Cuppari, Martin H. de Borst and Ita Pfeferman Heilberg

Lipids, 2025, 60, 261
DOI: 10.1002/lipd.12440

Exploring the Role of Mediterranean and Westernized Diets and Their Main Nutrients in the Modulation of Oxidative Stress in the Placenta: A Narrative Review

Cielo García-Montero, Oscar Fraile-Martinez, Diego De Leon-Oliva, Diego Liviu Boaru, Luis M. Garcia-Puente, Juan A. De León-Luis, Coral Bravo, Raul Diaz-Pedrero, Laura Lopez-Gonzalez, Melchor Álvarez-Mon, Natalio García-Honduvilla, Miguel A. Saez and Miguel A. Ortega

Antioxidants, 2023, 12, 1918
DOI: 10.3390/antiox12111918

Associations between Macronutrients Intake and Bone Mineral Density: A Longitudinal Analysis of the Health Workers Cohort Study Participants

Berenice Rivera-Paredez, G. León-Reyes, D. Rangel-Marín, J. Salmerón and Rafael Velázquez-Cruz

The Journal of nutrition, health and aging, 2023, 27, 1196
DOI: 10.1007/s12603-023-2038-2

Progress of Research on Effects of High-Fat Diet on Eye

梓菡万

ACM, 2023, 13, 15918
DOI: 10.12677/ACM.2023.13102225

Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis

Yuan-Wei Zhang, Yan Wu, Xiang-Fei Liu, Xiao Chen and Jia-Can Su

Ageing Research Reviews, 2024, 94, 102196
DOI: 10.1016/j.arr.2024.102196

Association of high-fat diet with bone mineral density in older U.S. adults: a cross-sectional study of NHANES 2017–2018

Na Li, Qing He, Yuan Cheng and Tao Jin

J Health Popul Nutr, 2025, 45
DOI: 10.1186/s41043-025-01224-3

The Effect of Unadjusted Mineral Supplementation on Bone Health of Preterm Infants Fed Fortified Human Milk: An Exploratory Analysis

Manuela Cardoso, Leonor Figueiredo, André Moreira-Rosário, José Camolas, Daniel Virella, Israel Macedo and Luís Pereira-da-Silva

Journal of Clinical Neonatology, 2024, 13, 48
DOI: 10.4103/jcn.jcn_10_24

Gut Microbiota and Serum Metabolic Signatures of High-Fat-Induced Bone Loss in Mice

Lingyun Lu, Mengjia Tang, Jiao Li, Ying Xie, Yujue Li, Jinwei Xie, Li Zhou, Yi Liu and Xijie Yu

Front. Cell. Infect. Microbiol., 2021, 11
DOI: 10.3389/fcimb.2021.788576

Diets intervene osteoporosis via gut-bone axis

Yuan-Wei Zhang, Pei-Ran Song, Si-Cheng Wang, Han Liu, Zhong-Min Shi and Jia-Can Su

Gut Microbes, 2024, 16
DOI: 10.1080/19490976.2023.2295432

Whey Protein Hydrolysate Ameliorated High-Fat-Diet Induced Bone Loss via Suppressing Oxidative Stress and Regulating GSK-3β/Nrf2 Signaling Pathway

Tingting Bu, Ju Huang, Yue Yu, Peilong Sun and Kai Yang

Nutrients, 2023, 15, 2863
DOI: 10.3390/nu15132863

Male but not female mice with severe osteogenesis imperfecta are partially protected from high-fat diet-induced obesity

Josephine T. Tauer, Iris Boraschi-Diaz, Omar Al Rifai, Frank Rauch, Mathieu Ferron and Svetlana V. Komarova

Molecular Genetics and Metabolism, 2021, 133, 211
DOI: 10.1016/j.ymgme.2021.03.014

Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis

Yizhou Zheng, Yaosheng Xiao, Di Zhang, Shanshan Zhang, Jing Ouyang, Linfu Li, Weimei Shi, Rui Zhang, Hai Liu, Qi Jin, Zhixi Chen, Daohua Xu and Longhuo Wu

Cells, 2021, 10, 3424
DOI: 10.3390/cells10123424

Ketogenic diet and β-hydroxybutyrate in osteoporosis: current progress and controversy

Changfang Luo, Zhuojun Dai, Wanhong He, Yanqiu He, Ping Yang, Mengting Huang, Junle Li, Yong Xu and Wei Huang

Front. Nutr., 2025, 12
DOI: 10.3389/fnut.2025.1508695

Metformin attenuates high-fat diet induced metabolic syndrome related osteoarthritis through inhibition of prostaglandins

Xiaonan Liu, Qiaoyue Guo, Lei Wang, Yiru Gu, Senxiong Meng, Yuan Gu and Bin Yu

Front. Cell Dev. Biol., 2023, 11
DOI: 10.3389/fcell.2023.1184524

How high‐fat diet affects bone in mice: A systematic review and meta‐analysis

Zheng Zhang, Zhanrong Zhang, Lei Pei, Xiaozhou Zhang, Boyuan Li, Yichen Meng and Xuhui Zhou

Obesity Reviews, 2022, 23
DOI: 10.1111/obr.13493

Plasma metabolites mediate the causal effect of carbohydrate intake on bone mineral density

Xinyi Zhao and Keng Chen

Medicine, 2025, 104, e43608
DOI: 10.1097/MD.0000000000043608

Chromium nanoparticles improve bone turnover regulation in rats fed a high-fat, low-fibre diet

Ewelina Cholewińska, Przemysław Sołek, Jerzy Juśkiewicz, Bartosz Fotschki, Wojciech Dworzański, Katarzyna Ognik and Satish Rojekar

PLoS ONE, 2024, 19, e0300292
DOI: 10.1371/journal.pone.0300292

Advances in the interaction between endoplasmic reticulum stress and osteoporosis

Mingliang Zhong, Zhenyu Wu, Zhixi Chen, Qun Ren and Jianguo Zhou

Biomedicine & Pharmacotherapy, 2023, 165, 115134
DOI: 10.1016/j.biopha.2023.115134

High-fat diet, intestinal microecology and bone loss

Ning Wang, Xue Tong and Yi-kai Li

Nutr Metab (Lond), 2025, 22
DOI: 10.1186/s12986-025-01013-z

Association between gut microbiota and bone metabolism: Insights from bibliometric analysis

Zhanrong Zhang, Zheng Zhang, Haoming Shu, Yichen Meng, Tao Lin, Jun Ma, Jianquan Zhao and Xuhui Zhou

Front. Physiol., 2023, 14
DOI: 10.3389/fphys.2023.1156279

Oxidative stress: A common pathological state in a high-risk population for osteoporosis

Chi Zhang, Hao Li, Jie Li, Jiajin Hu, Keda Yang and Lin Tao

Biomedicine & Pharmacotherapy, 2023, 163, 114834
DOI: 10.1016/j.biopha.2023.114834

Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues

Sara K. AlMarzooqi, Fajr Almarzooqi, Hana Q. Sadida, Jayakumar Jerobin, Ikhlak Ahmed, Abdul‐Badi Abou‐Samra, Khalid A. Fakhro, Punita Dhawan, Ajaz A. Bhat and Ammira S. Al‐Shabeeb Akil

Obesity Reviews, 2024, 25
DOI: 10.1111/obr.13766

High-fat diet-induced osteoporosis in mice under hypoxic conditions

Yajun Qiao, Huimin Zheng, Ruiying Cheng, Juan Guo, Li Ji, Zhibin Liu, Lixin Wei, Hongtao Bi and Zhongshu Shan

BMC Musculoskelet Disord, 2025, 26
DOI: 10.1186/s12891-025-08725-6

Gut microbiota and bone metabolism

Lingyun Lu, Xiaoxuan Chen, Yi Liu and Xijie Yu

The FASEB Journal, 2021, 35
DOI: 10.1096/fj.202100451R

Association of dietary carbohydrate intake with bone mineral density, osteoporosis and fractures among adults without diabetes: Evidence from National Health and Nutrition Examination Survey

Ran Chen, Kai Gong, Wei Chen, Zongfeng Chen, Lianyang Zhang, Ying Tang, Yang Li and Siru Zhou

Heliyon, 2024, 10, e35566
DOI: 10.1016/j.heliyon.2024.e35566

New insights into the mechanisms of high‐fat diet mediated gut microbiota in chronic diseases

Jiali Chen, Yuhang Xiao, Dongmei Li, Shiqing Zhang, Yingzi Wu, Qing Zhang and Weibin Bai

iMeta, 2023, 2
DOI: 10.1002/imt2.69

Non-Alcoholic Fatty Liver Disease and Bone Tissue Metabolism: Current Findings and Future Perspectives

Oxana M. Drapkina, Anastasia Yu. Elkina, Anna F. Sheptulina and Anton R. Kiselev

IJMS, 2023, 24, 8445
DOI: 10.3390/ijms24098445

Genetic insights into dietary patterns, liposome mediation, and osteoporosis risk: a Mendelian randomization study

Kehan Long, Tengfei Zheng, Ao Gong, Zhendong Ying and Lei Zhang

Front. Nutr., 2024, 11
DOI: 10.3389/fnut.2024.1389896

Fecal Microbiota Transplantation from Mice Receiving Magnetic Mitohormesis Treatment Reverses High-Fat Diet-Induced Metabolic and Osteogenic Dysfunction

Jun Kit Craig Wong, Bharati Kadamb Patel, Yee Kit Tai, Tuan Zea Tan, Wei Wei Thwe Khine, Way Cherng Chen, Marek Kukumberg, Jianhong Ching, Lye Siang Lee, Kee Voon Chua, Tsze Yin Tan, Kwan Yu Wu, Xizhe Bai, Jan Nikolas Iversen, Kristy Purnamawati, Rufaihah Abdul Jalil, Alan Prem Kumar, Yuan Kun Lee, Shabbir M. Moochhala and Alfredo Franco-Obregón

IJMS, 2025, 26, 5450
DOI: 10.3390/ijms26125450

Lipid metabolism related inflammation modulates ocular growth in a high-fat diet guinea pig model

Xiaoran Zhang, Yamin Chen, Kailei Wang, Ning Zhang, Zichen Luan and Rui Hao

J Transl Med, 2026
DOI: 10.1186/s12967-026-07977-7

Visceral adiposity measured by Body Roundness Index linked to higher all-cause and cardiovascular mortality in osteoarthritis: Results from NHANES 1999 to 2018

Yifeng Huang, Abudousaimaiti Maimaituxun, Qizhang Man, Song Liu, Ying Yang, Jinfeng Wen, Hao Xie, Lei Fan and Xiao-Long Hu

Medicine, 2026, 105, e47207
DOI: 10.1097/MD.0000000000047207

Brown adipose tissue-derived extracellular vesicles regulate hepatocyte mitochondrial activity to alleviate high-fat diet-induced jawbone osteoporosis in mice

Kai Zhang, Sha Zhang, Guorong Deng, Guangxiang He, Yuan Yuan, Yu Fu, Yihan Liu, Zhen Gong, Liang Kong and Chenxi Zheng

Front. Endocrinol., 2025, 16
DOI: 10.3389/fendo.2025.1583408

Bacteroides acidifaciens alleviates high-fat diet-induced obesity-related osteoporosis by regulating gut microbiota and bile acid metabolism via the gut-bone axis

Cihua Zheng, Jian Xie, Furui Tang, Zhuoya Wang, Li Liu, Yimin Pi, Yuchun Zhong, Zhidong He, Tian Liu, Jiacheng Zheng and Jun Luo

Microbiological Research, 2026, 303, 128393
DOI: 10.1016/j.micres.2025.128393

Machine-learning prediction of BMI change among doctors and nurses in North China during the COVID-19 pandemic

Qihe Wang, Haiyun Chu, Pengfeng Qu, Haiqin Fang, Dong Liang, Sana Liu, Jinliang Li and Aidong Liu

Front. Nutr., 2023, 10
DOI: 10.3389/fnut.2023.1019827

Understanding Glucocorticoid-induced Osteoporosis: Causes, Effects and Management

Mozhdeh Ghamari, Farnoosh Ebrahimzadeh and Kamila Hashemzadeh

Indian Journal of Rheumatology, 2025
DOI: 10.1177/09733698251345210

The effects of a diet with high fat content from lard on the health and adipose-markers’ mRNA expression in mice

Dinh-Toi Chu, Hue Vu Thi, Nhat-Le Bui and Ngoc-Hoan Le

Science Progress, 2024, 107
DOI: 10.1177/00368504241269431

The Impact of Diet on Bone and Fracture Risk in Diabetes

M. Faraj and N. Napoli

Curr Osteoporos Rep, 2022, 20, 26
DOI: 10.1007/s11914-022-00725-y

Obesity, Dietary Patterns, and Hormonal Balance Modulation: Gender-Specific Impacts

Elisa Mazza, Ersilia Troiano, Yvelise Ferro, Fabrizia Lisso, Martina Tosi, Ettore Turco, Roberta Pujia and Tiziana Montalcini

Nutrients, 2024, 16, 1629
DOI: 10.3390/nu16111629

Indole-3 propionate inhibits NF-κB/NLRP3-mediated osteoclastogenesis and improves bone quality in high-fat-diet induced obese mice

Runze Wu, Yinghong Kong, Jianfeng Li, Hao Chen, Yujie Jiao, Cheng Sun and Yuejun Ju

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2025, 1871, 167952
DOI: 10.1016/j.bbadis.2025.167952

Pregnancy-Associated Plasma Protein (PAPP)-A2 in Physiology and Disease

Vicente Barrios, Julie A. Chowen, Álvaro Martín-Rivada, Santiago Guerra-Cantera, Jesús Pozo, Shoshana Yakar, Ron G. Rosenfeld, Luis A. Pérez-Jurado, Juan Suárez and Jesús Argente

Cells, 2021, 10, 3576
DOI: 10.3390/cells10123576

The impacts on bone structures and metabolisms by high-fat diet caused osteoporosis in mice: a meta-analysis and systematic review

Qiangqiang Lian, Hetong Li, Faming Tian, Yu Gou, Yunpeng Hu and Liu Zhang

CyTA - Journal of Food, 2024, 22
DOI: 10.1080/19476337.2023.2276831