Issue 51, 2012
From the journal:

Chemical Communications

Folding super-sized DNA origami with scaffold strands from long-range PCR†

Honglu Zhang,a   Jie Chao,*a   Dun Pan,a   Huajie Liu,a   Qing Huanga  and  Chunhai Fan*a  

* Corresponding authors

a Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
E-mail: chaojie@sinap.ac.cn, fchh@sinap.ac.cn

Abstract

A 26 kilobase single strand DNA fragment was obtained from long-range PCR amplification and subsequent enzymatic digestion, which we folded into a super-sized DNA origami nanostructure by using ∼800 staple strands.

Graphical abstract: Folding super-sized DNA origami with scaffold strands from long-range PCR

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Article information

DOI
https://doi.org/10.1039/C2CC32204H
Article type
Communication
Submitted
27 Mar 2012
Accepted
23 Apr 2012
First published
24 Apr 2012

Chem. Commun., 2012,48, 6405-6407

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Folding super-sized DNA origami with scaffold strands from long-range PCR

H. Zhang, J. Chao, D. Pan, H. Liu, Q. Huang and C. Fan, Chem. Commun., 2012, 48, 6405 DOI: 10.1039/C2CC32204H

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