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Herein, we report on the construction of Cu–histidine (His)–DNA hybrids as laccase-mimetic DNAzymes. Cu–His–DNAzymes showed remarkable activity in a colorimetric oxidation reaction between 2,4-dichlorophenol and 4-aminoantipyrine. Our results provide new insights for the systematic construction of tailor-made active sites for biomimetics.

Graphical abstract: Histidine–DNA nanoarchitecture as laccase mimetic DNAzymes

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