Issue 19, 2012
From the journal:

Organic & Biomolecular Chemistry

A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines†‡

Jie Chen,a   Ling Zhoua  and  Ying-Yeung Yeung*a  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
E-mail: chmyyy@nus.edu.sg
Fax: +65 6779 1691
Tel: +65 6516 7760

Abstract

A facile and highly enantioselective approach towards 2-substituted 3-bromopyrrolidines has been developed. The process involves an amino-thiocarbamate catalyzed bromoaminocyclization of 1,2-disubstituted olefinic amides. The pyrrolidine products could readily be converted into other useful building blocks including a dihydropyrrole and a 2-substituted pyrrolidine.

Graphical abstract: A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines

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Article information

DOI
https://doi.org/10.1039/C2OB25327E
Article type
Communication
Submitted
14 Feb 2012
Accepted
06 Mar 2012
First published
07 Mar 2012

Org. Biomol. Chem., 2012,10, 3808-3811

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A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines

J. Chen, L. Zhou and Y. Yeung, Org. Biomol. Chem., 2012, 10, 3808 DOI: 10.1039/C2OB25327E

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