Efficient synthesis of non-natural ganglioside (pseudo-GM3) and fluorescent labelled lysoGM3 on the basis of polymer-assisted enzymatic strategy

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Kuriko Yamada, Susumu Matsumoto and Shin-Ichiro Nishimura


Abstract

The versatility of polymer-assisted enzymatic synthesis of non-natural and biologically significant glycolipid derivatives was demonstrated by constructing pseudo-ganglioside GM3 1 having the trisaccharide sequence Neu5Acα- (2→6)Galβ(1→4)Glc and a fluorescent labelled lysoGM3 2.


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