Enantioselective hydrogenation of a cyclic imidoketone over chirally modified Pt/Al₂O₃

Abstract

1-Ethyl-4,4-dimethylpyrrolidine-2,3,5-trione 1 has been synthesized, and hydrogenated with 91% ee to (R)-1-ethyl-3-hydroxy-4,4-dimethylpyrrolidine-2,5-dione (2) using a 5 mass% Pt/Al₂O₃ catalyst modified by cinchonidine

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