Design, synthesis and cleaving activity of an abiotic nuclease based on a manganese(III) porphyrin complex bearing two acridine moieties

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Cathy Drexler, Mir Wais Hosseini, Cathy Drexler, Geneviève Pratviel and Bernard Meunier


Abstract

The synthesis of meso-5,15-bis(m-aminophenyl)porphyrin bearing two acridine derivatives and of its manganese(III) complex was achieved; in the presence of oxygen atom donors, the metalloporphyrin was shown to cleave double-stranded DNA.


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