A ring-opening rearrangement reaction of N-cyclopropylamides is shown to occur in the presence of AlCl3. The mechanism proposed herein involves the “Heine-type” aziridine intermediate and C–Cl or C–O bond formation.
Simple strategy for the synthesis of well-defined light- and temperature-responsive poly(2-oxazoline)s via modification of partly hydrolyzed poly(2-ethyl-2-oxazoline).
We demonstrate the potential of Ni(COD)(DQ), a bench-stable Ni0 complex, as a catalyst for the reductive coupling of aldehydes with alkynes and ynamides, providing silylated allyl alcohols with excellent yields and regioselectivities.
A visible-light-mediated tandem ring opening/1,6-conjugate addition of cyclobutanols with p-quinone methides was developed. This protocol allowed the formation of δ,δ-diaryl ketones in the presence of a readily available organic photocatalyst.
Dihydro[1,2,3]triazolo-pyrimidoisoindolones and dihydro[1,2,3]triazolo-diazepinoisoindolones can conveniently be synthesized from sodium azide and alkyne substituted amido alcohols in good yields using the Huisgen reaction.