Intermolecular carboamination of allyl amines under Pd(II)-catalysis is reported, expediting the synthesis of vicinal diamines embedded in a functionally enriched linear carbon framework with high yields and exclusive Markovnikov selectivity.
Carboamination of alkenes is rapidly emerging as an essential strategy for synthesizing complex nitrogen-containing compounds.
This review discusses emerging strategies in three-component, stereoselective C–N bond-forming alkene difunctionalization, emphasizing mechanistic innovations and their impact on synthetic organic chemistry.
An in-depth mechanistic probe of the Cu-catalysed electrophilic carboamination of terminal alkynes with benzyne and an hydroxylamine ester provided a computationally verified mechanistic view, thus enabling further rational catalyst improvement.
Intermolecular carboamination of olefins offers a powerful platform for the rapid construction of structurally complex amines from abundant feedstocks.