Structural Unfolding of G-Quadruplexes: From Small Molecules to Antisense Strategies

Giorgia Fracchioni, Sabrina Vailati, Marta Grazioli and Valentina Pirota

Molecules, 2024, 29, 3488
DOI: 10.3390/molecules29153488

Modulation of Nrf2 expression by targeting i-motif DNA

E. F. Warner, D. Guneri, M. A. O’Connell, C. J. MacDonald and Z. A. E. Waller

Commun Chem, 2025, 8
DOI: 10.1038/s42004-024-01387-w

I-motif formation in the promoter region of the B-MYB proto-oncogene

André Alves, André Miranda, Irene Zanin, Sara N. Richter, Jean-Louis Mergny and Carla Cruz

International Journal of Biological Macromolecules, 2025, 296, 139582
DOI: 10.1016/j.ijbiomac.2025.139582

Cellular adaptations impact the biological activity of naphthalene diimide G-quadruplex ligands in ALT-positive osteosarcoma cells

Joanna Bidzinska, Lorenzo Di Pietro, Eisa Naghshineh, Cecilia Pandini, Filippo Doria, Nadia Zaffaroni, Paolo Gandellini, Stephen Neidle and Marco Folini

Cell Death Dis, 2025, 16
DOI: 10.1038/s41419-025-07908-2

Structure–Activity Study on Substituted, Core-Extended, and Dyad Naphthalene Diimide G-Quadruplex Ligands Leading to Potent Antitrypanosomal Agents

Alessandra Benassi, Pablo Peñalver, Manuel Pérez-Soto, Valentina Pirota, Mauro Freccero, Juan Carlos Morales and Filippo Doria

J. Med. Chem., 2024, 67, 10643
DOI: 10.1021/acs.jmedchem.4c00135

G-quadruplex and i-motif DNA structures form in the promoter of the key innate immune adaptor MYD88

Susie Brown, Kennith Swafford, Mason McCrury, Farhana Nasrin, Carlon Q. Gragg, Arundhati Chavan, Samrat Roy Choudhury, Jonathan Dickerhoff, Danzhou Yang and Samantha Kendrick

Cell Reports Physical Science, 2025, 6, 102560
DOI: 10.1016/j.xcrp.2025.102560

The versatile NDI-based compounds: emerging anticancer and antimicrobial agents

Beatrice Tosoni, Matteo Nadai, Alessio Maria Caramiello, Filippo Doria, Mauro Freccero and Sara N. Richter

Med Chem Res, 2024, 33, 2030
DOI: 10.1007/s00044-024-03329-6