Computational modeling-guided design of deep eutectic solvents for tailoring lignin chemistry during lignocellulose pretreatment

Le Zhou, Xianzhi Meng, Weiwei Li, Jiali Yu, Christian O. Kemefa, Susie Y. Dai, Arthur J. Ragauskas and Joshua S. Yuan

Green Chem., 2025, 27, 6260
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Evoking research attention back on liquid hot water pretreatment: a comprehensive review

Chen Huang, Xuelian Zhou, Yunni Zhan, Xianzhi Meng, Guigan Fang, Zhe Ling, Lingfeng Long and Arthur J. Ragauskas

Green Chem., 2025, 27, 4408
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A guide to lignin valorization in biorefineries: traditional, recent, and forthcoming approaches to convert raw lignocellulose into valuable materials and chemicals

Filippo Brienza, David Cannella, Diego Montesdeoca, Iwona Cybulska and Damien P. Debecker

RSC Sustainability, 2024, 2, 37
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Preparation of homogeneous lignin nanoparticles by efficient extraction of lignin and modification of its molecular structure using a functional deep eutectic solvent containing γ-valerolactone

Mingzhu Yao, Baojie Liu, Lina Qin, Zicheng Du, Zenglin Wang, Chengrong Qin, Chen Liang, Caoxing Huang and Shuangquan Yao

Green Chem., 2024, 26, 4528
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Densification pretreatment with a limited deep eutectic solvent triggers high-efficiency fractionation and valorization of lignocellulose

Guannan Shen, Xinchuan Yuan, Yin Cheng, Sitong Chen, Zhaoxian Xu and Mingjie Jin

Green Chem., 2023, 25, 8026
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Magnetically recyclable vanadium-substituted phosphotungstic acid in a deep eutectic solvent for effective wheat straw fractionation

Xirun Zhao, Gaojin Lyu, Chang Geun Yoo, Zhen Wang and Jiachuan Chen

Green Chem., 2025
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The dawn of aqueous deep eutectic solvents for lignin extraction

Mingyang Hu, Yanyan Yu, Xiaoyan Li, Xinyu Wang and Yun Liu

Green Chem., 2023, 25, 10235
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Integrating DES Pretreatment and Enzymatic Saccharification for Napier Grass Valorization

Diana Jose, Yu-Shen Cheng, Senthil Muthu Kumar Thiagamani, Santi Chuetor, Theerawut Phusantisampan, Prapakorn Tantayotai and Malinee Sriariyanun

Waste Biomass Valor, 2025
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Enhanced Enzymatic Hydrolysis of Tobacco Stalk via Simultaneous Deconstruction and Modification through Triton X‐100‐Mediated Organosolv Pretreatment

Dan Liu, Guojie Song, Liang Liu, Meysam Madadi, Caiyue Li, Wenhao Hu, Yao Zhang, Zicheng Liu, Chihe Sun and Fubao Sun

ChemSusChem, 2025, 18
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Enhancing enzymatic saccharification and valuable lignin recovery from wheat straw using a novel ternary deep eutectic solvent pretreatment

Yuanyuan Xia and Jingshun Zhuang

Industrial Crops and Products, 2025, 232, 121245
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Novel one-step lignin microsphere preparation for oral tissue regeneration applications

Anyuan Shi, Li Guo, Chunning Gu, Yunni Zhan, Xuelian Zhou and Wei Cheng

Front. Bioeng. Biotechnol., 2025, 12
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Biodegradable Liquid Slow-Release Mulch Film Based on Bamboo Residue for Selenium-Enriched Crop Cultivation

Chaoqi Chen, Zhaoshuang Li, Kuaile Yin, Lei Li, Zhen Zhang, Xu Xu, He Liu, Yan Qing, Xingong Li and Yiqiang Wu

Research, 2025, 8
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Heteroatom-engineered multicolor lignin carbon dots enabling bimodal fluorescent off-on detection of metal-ions and glutathione

Pengfei Zhou, Jikun Xu, Xinyan Hou, Lin Dai, Jiaming Zhang, Xiao Xiao and Kaifu Huo

International Journal of Biological Macromolecules, 2023, 253, 126714
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Insights into environmentally friendly solvent pretreatment of lignocellulosic biomass: Strategies, mechanisms, and future perspectives

Qianli Wang, Jiaqi Chen, Yuebin Lian, Qingang Xiong, Jun-ichiro Hayashi, Chen Huang, Arthur J. Ragauskas, Xianzhi Meng and Yefeng Zhou

Carbohydrate Polymers, 2025, 367, 124027
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Modification of Condensed Lignin by Deep Eutectic Solvents: Insight into the Mechanism of Improving the Enzymatic Saccharification

Tingjun Chen, Xuelian Zhou, Yunni Zhan, Jinyuan Cheng, Caoxing Huang, Chang Geun Yoo, Guigan Fang, Arthur J. Ragauskas, Xianzhi Meng and Chen Huang

ACS Sustainable Chem. Eng., 2024, 12, 18555
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Deep‐eutectic‐solvent‐assisted hydrothermal carbonization of sewage sludge for green wood bioadhesive production

Zhi‐Xiang Xu, Rui Dou, Yi Tan, Huan‐Ran Xiong, Yong‐Xing Chen, Li‐Jian Leng, Mikhail Vlaskin, Sameh M. Osman and Rafael Luque

Biofuels Bioprod Bioref, 2024, 18, 1978
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Ammonia combined with hydrogen peroxide pretreatment to improve the production of fermentable sugars in reed

Hui Zhao, Lei Peng, Yehan Tao, Jian Du, Yanna Lv, Jinwen Hu, Jie Lu and Haisong Wang

Biomass Conv. Bioref., 2025, 15, 19771
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Novel ternary acidic deep eutectic solvent with high recyclability aimed at selective fractionation of lignin and fermentable sugars from bamboo

Chen Xu, Fanyang Meng, Yaru Li and Hui Pan

International Journal of Biological Macromolecules, 2025, 307, 142231
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Preparation of a Brown Alga-Inspired, Multifunctional, and Bionic Soy Protein Adhesive Based on Bamboo Cellulose Nanofiber and Rosin Acid

Yinchun Hu, Zhenyang Bao, Zhaoshuang Li, Renzhong Wei, Tonghua Ma, Xiaobing Xie, Guoen Yang, Yan Qing, Xingong Li and Yiqiang Wu

ACS Sustainable Chem. Eng., 2025, 13, 1056
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Lower temperature pretreatment of wheat straw for high production of fermentable sugars using ball-milling combined with deep eutectic solvent

Li Wang, Jing-jing Guo and Zhen Fang

Renewable Energy, 2025, 241, 122240
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Deep eutectic solvent-enabled lignocellulosic biomass valorization: Toward understanding of biomass pretreatment, lignin dissolution, and lignin's antioxidant activity

Yue Zhang, Shibo Liu, Deling Xu and Gang Cheng

International Journal of Biological Macromolecules, 2025, 301, 140257
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Efficient dissolution of lignin during lignocellulosic biomass fractionation using deep eutectic solvents

Minglu Zhang, Congzhe Ren, Xiaozhe Song, Ruiyan Zhang, Xiaoguo Shi, Huning Zhang, Dandan Ji and Lihua Zang

Biomass and Bioenergy, 2025, 197, 107836
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Highly robust, self-adhesive, self-healing, pH-responsive, cytocompatible and degradable collagen/PVA/tannin-based conductive hydrogel sensor for motion-monitoring

Xin Shi, Maohua Lan, Jiachang Liu, Jin Zhou and Haibin Gu

Polymer, 2024, 308, 127365
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Direct Extraction of Uniform Lignin Microspheres from Bamboo Using a Polyol-Based Deep Eutectic Solvent

Jinyuan Cheng, Chen Huang, Xuze Liu, Xuelian Zhou, Yunni Zhan, Tingjun Chen, Caoxing Huang, Xianzhi Meng, Guigan Fang and Arthur J. Ragauskas

ACS Sustainable Chem. Eng., 2023, 11, 10158
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Optimization of Cellulose Recovery Using Deep Eutectic Solvent Fractionation: A Response Surface Method Approach

Nopparat Suriyachai, Punjarat Khongchamnan, Navadol Laosiripojana, Torpong Kreetachat, Surachai Wongcharee, Chainarong Sakulthaew, Chanat Chokejaroenrat and Saksit Imman

Energies, 2024, 17, 4257
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A novel mineral-acid free biphasic deep eutectic solvent/γ-valerolactone system for furfural production and boosting the enzymatic hydrolysis of lignocellulosic biomass

Jinyuan Cheng, Chen Huang, Yunni Zhan, Xuze Liu, Jia Wang, Caoxing Huang, Guigan Fang, Arthur J. Ragauskas, Zhanghong Xie and Xianzhi Meng

Bioresource Technology, 2023, 387, 129653
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Pretreatment of poplar with eco-friendly levulinic acid to achieve efficient utilization of biomass

Jiao Li, Baojie Liu, Lu Liu, Yadan Luo, Fanyan Zeng, Chengrong Qin, Chen Liang, Caoxing Huang and Shuangquan Yao

Bioresource Technology, 2023, 376, 128855
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Surfactant-assisted dilute ethylenediamine fractionation of corn stover for technical lignin valorization and biobutanol production

Di Cai, Jieyi Wen, Yilu Wu, Changsheng Su, Haoran Bi, Yankun Wang, Yongjie Jiang, Peiyong Qin, Tianwei Tan and Changwei Zhang

Bioresource Technology, 2024, 394, 130231
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A designed ZrOCl2/ethylene glycol deep eutectic solvent for efficient lignocellulose valorization

Yunhua Bai, Xiong-Fei Zhang, Mengjiao Yu and Jianfeng Yao

International Journal of Biological Macromolecules, 2024, 275, 133507
DOI: 10.1016/j.ijbiomac.2024.133507

Research progress of deep eutectic solvents in lignocellulosic biomass pretreatment

Xinyu Zhang, Ai Liu, Xianghong Li, Wenbiao Xu, Xixin Duan, Junyou Shi and Xiangyu Li

Cellulose, 2025, 32, 4637
DOI: 10.1007/s10570-025-06553-4

DES-driven sustainable dual valorization of lignocellulose into carbon dots and porous biochar for effective wastewater remediation

Si Hong, Aocheng Wei, Chao Xie, Xiaojun Shen, Jia-Long Wen and Tong-Qi Yuan

International Journal of Biological Macromolecules, 2024, 282, 137159
DOI: 10.1016/j.ijbiomac.2024.137159

Deep eutectic solvents promote in-situ hydrogenolysis of Evodia lepta residue in preparing small aromatic phenol ketones

Shutian Chen, Yating Jian, Yaowei Liu, Zhanying Zhang, Xinlong Li and Qiang Yu

Fuel, 2024, 366, 131348
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Sustainable upcycling of sugarcane bagasse into nanofibrillated cellulose utilizing novel green solvents and high intensity ultrasonication

Archana Pandey, Ajay S. Kalamdhad and Yogesh Chandra Sharma

Sustainable Chemistry and Pharmacy, 2024, 37, 101373
DOI: 10.1016/j.scp.2023.101373

Bringing multiscale dot-sheet heterostructured assembly into lignin valorization for efficient water desalination and zinc-ion hybrid capacitors

Pengfei Zhou, Jun Guo, Xiao Xiao, Lin Dai, Kaifu Huo and Jikun Xu

Chemical Engineering Journal, 2024, 498, 155788
DOI: 10.1016/j.cej.2024.155788

γ-Valerolactone/CuCl2 biphasic system for high total monosaccharides recovery from pretreatment and enzymatic hydrolysis processes of eucalyptus

Shuhua Mo, Yao Zheng, Jianyu Gong and Minsheng Lu

Front. Chem. Sci. Eng., 2024, 18
DOI: 10.1007/s11705-024-2490-5

Novel self-pretreatment of biomass by in-situ preparation of acid-assisted carbohydrate-derived DES

Si Hong, Chao Xie, Xiaojun Shen, Jia-Long Wen and Tong-Qi Yuan

Industrial Crops and Products, 2024, 222, 119770
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Direct solvolysis of papermaking black liquor in strong alkali coupled with catalytic hydrodeoxygenation to produce aviation fuel-range arenes

Zifan Wu, Lu Chen, Yacong Deng, Yuting Qiu, Bin Liu, Yichuan Li, Yuan Pan, Bin Dong and Yongming Chai

Industrial Crops and Products, 2025, 235, 121823
DOI: 10.1016/j.indcrop.2025.121823

Combined liquid hot water and sulfonation pretreatment of sugarcane bagasse to maximize fermentable sugars production

Aissata Ousmane Kane, Anelyse Abreu Cortez, Vanessa Oliveira Arnoldi Pellegrini, Balla Diop Ngom, Jefferson G. Filgueiras, Eduardo R. de Azevedo and Igor Polikarpov

Industrial Crops and Products, 2023, 201, 116849
DOI: 10.1016/j.indcrop.2023.116849

Developments and perspectives on lignin-first biomass pretreatment for efficient enzymatic hydrolysis and isolation of lignin with minimized degradation

Shibo Liu and Gang Cheng

Industrial Crops and Products, 2024, 208, 117926
DOI: 10.1016/j.indcrop.2023.117926

A green and efficient approach for the simultaneous extraction and mechanisms of essential oil and lignin from Cinnamomum camphora: Process optimization based on deep learning

Hongxiang Yang, Peng Zhou, Xiangzhou Li and Liqun Shen

International Journal of Biological Macromolecules, 2024, 277, 134215
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Towards valorization of rice straw into bioethanol and lignin: Emphasizing critical role of deep eutectic solvent components in biorefining process

Pengfei Zhao, Fulong Pu, Changsheng Su, Yefan Wan, Texin Huang, Xuedan Hou and Di Cai

Bioresource Technology, 2024, 399, 130635
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Facilitating lignocellulose fractionation of Moringa oleifera Lam. husk by pretreatment with a novel 1-tetradecyl-3-carboxymethylimidazolium bromide-based deep eutectic solvent

Jiabo Cheng, Yuan Gao, Jie Liu, Yuting Zhang, Mengfei Tian, Mengying Zhang, Yaru Zhang, Chunjian Zhao and Chunying Li

Journal of Cleaner Production, 2024, 483, 144249
DOI: 10.1016/j.jclepro.2024.144249

Efficient fractionation of lignin from Camellia oleifera shell by acidic deep eutectic solvent under mild conditions

Kexin Chen, Jin Sun, Xianfeng Hou, Haiyang Zhou and Zhenzhong Gao

Journal of Industrial and Engineering Chemistry, 2025, 146, 697
DOI: 10.1016/j.jiec.2024.11.055

A selective oxidative depolymerization of larch lignin to ethyl vanillate by multifunctional catalysts combining alkaline ionic liquid and polyoxometalates with hydrogen peroxide

Kuiyuan Cao, Fang Yang, He Wan, Xixin Duan, Junyou Shi and Zhong Sun

International Journal of Biological Macromolecules, 2025, 295, 139642
DOI: 10.1016/j.ijbiomac.2025.139642

Study of the Effects of the Water and Ethylene Glycol on Biomass Pretreatment Using a Deep Eutectic Solvent and Evaluation of the Antioxidant Activity of Lignins

Shibo Liu, Yue Zhang, Lin Chen, Yuan Fang, Jia-Long Wen and Gang Cheng

Ind. Eng. Chem. Res., 2025, 64, 5158
DOI: 10.1021/acs.iecr.4c04772

Mechanochemical Fractionation of Straw Biomass to Maximize Biorefinery Value Using Alkaline Deep Eutectic Solvents at Room Temperature

Baiheng Jiang, Qihang Tang, Hongan Yu, Qiongyao Su, Feiyue Shen, Li Zhao, Jinguang Hu, Dong Tian and Fei Shen

ACS Sustainable Chem. Eng., 2024, 12, 13960
DOI: 10.1021/acssuschemeng.4c04802

Green bio-based aprotic solvents for efficient fractionation of hemicellulose and targeted value addition of lignin

Jiao Li, Tao Li, Yang Wang, Zicheng Du, Yadan Luo, Chengrong Qin, Chen Liang, Caoxing Huang and Shuangquan Yao

Industrial Crops and Products, 2023, 205, 117453
DOI: 10.1016/j.indcrop.2023.117453