One-pot organocatalyzed synthesis of tricyclic indolizines

Lucas A. Zeoly, Lais V. Acconcia, Manoel T. Rodrigues, Hugo Santos, Rodrigo A. Cormanich, Juan C. Paniagua, Albert Moyano and Fernando Coelho

Org. Biomol. Chem., 2023, 21, 3567
DOI: 10.1039/D3OB00346A

Morita–Baylis–Hillman reaction: how do optimal enzyme active sites compare with organocatalysts

Tuğçe Ütnier and Nihan Çelebi-Ölçüm

Catal. Sci. Technol., 2023, 13, 329
DOI: 10.1039/D2CY00929C

Morita–Baylis–Hillman reaction in eutectic solvent under aqueous medium

Sanhu Zhao, Hangyu Zhi, Mi Zhang, Qin Yan, Jianfeng Fan and Jinchang Guo

RSC Adv., 2016, 6, 62778
DOI: 10.1039/C6RA04710F

Chemoselective and site-selective peptide and native protein modification enabled by aldehyde auto-oxidation

Landa Purushottam, Srinivasa Rao Adusumalli, Maheshwerreddy Chilamari and Vishal Rai

Chem. Commun., 2017, 53, 959
DOI: 10.1039/C6CC09555K

Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction

Rebecca Crawshaw, Amy E. Crossley, Linus Johannissen, Ashleigh J. Burke, Sam Hay, Colin Levy, David Baker, Sarah L. Lovelock and Anthony P. Green

Nat. Chem., 2022, 14, 313
DOI: 10.1038/s41557-021-00833-9

Unlocking the function promiscuity of old yellow enzyme to catalyze asymmetric Morita-Baylis-Hillman reaction

Lei Wang, Yaoyun Wu, Jun Hu, Dejing Yin, Wanqing Wei, Jian Wen, Xiulai Chen, Cong Gao, Yiwen Zhou, Jia Liu, Guipeng Hu, Xiaomin Li, Jing Wu, Zhi Zhou, Liming Liu and Wei Song

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-50141-2

Protein–Protein Interaction in Multicomponent Reaction Enables Chemoselective, Site-Selective, and Modular Labeling of Native Proteins

Rajib Molla, Pralhad N. Joshi, Neelesh C. Reddy, Dwaipayan Biswas and Vishal Rai

Org. Lett., 2023, 25, 6385
DOI: 10.1021/acs.orglett.3c02405

One‐Pot Morita–Baylis–Hillman/Allylic Substitution in Deep Eutectic Solvents: Access to γ‐Hydroxy Derivatives via Sequential CC and CX (X = P, N, S, B, Si) Bond Formation

Marina Ramos‐Martín, Ignacio del Río, Joaquín García‐Álvarez and Alejandro Presa Soto

ChemSusChem, 2026, 19
DOI: 10.1002/cssc.202501674

Engineering the simply asymmetric Morita–Baylis–Hillman reactions in a sodium phosphate buffer system: from enzyme‐ to proline‐catalyzed transformation

Xiaotong Du, Xiumei Cui, Xiaojun Gao and Liangyu Zheng

J of Chemical Tech & Biotech, 2022, 97, 2912
DOI: 10.1002/jctb.7166

New functionalized scaffolds from hydroxymethylfurfural and glucosyloxymethylfurfural by Morita–Baylis–Hillman reaction with cycloalkenones

Lianjie Wang, Jia-Neng Tan, Mohammed Ahmar and Yves Queneau

Comptes Rendus. Chimie, 2019, 22, 615
DOI: 10.1016/j.crci.2019.09.002

The Application of Biocatalysis in the Preparation and Resolution of Morita‐Baylis‐Hillman Adducts and Their Derivatives

Wanyama Peter Juma, Dubekile Nyoni, Dean Brady and Moira L. Bode

ChemBioChem, 2022, 23
DOI: 10.1002/cbic.202100527

Recent Advances in Catalytic Systems for the Mechanistically Complex Morita–Baylis–Hillman Reaction

Hugo Santos, Lucas A. Zeoly, Manoel T. Rodrigues, Fábio S. Fernandes, Ralph C. Gomes, Wanda P. Almeida and Fernando Coelho

ACS Catal., 2023, 13, 3864
DOI: 10.1021/acscatal.2c06420

Computational enzyme design by catalytic motif scaffolding

Markus Braun, Adrian Tripp, Morakot Chakatok, Sigrid Kaltenbrunner, Celina Fischer, David Stoll, Aleksandar Bijelic, Wael Elaily, Massimo G. Totaro, Melanie Moser, Shlomo Y. Hoch, Horst Lechner, Federico Rossi, Matteo Aleotti, Mélanie Hall and Gustav Oberdorfer

Nature, 2026, 649, 237
DOI: 10.1038/s41586-025-09747-9

Comparison between Chemoenzymatic and Bienzymatic Cascades Leading to Morita–Baylis–Hillman Adducts

Yinuo Li, Cuiyu Bao, Zhoutong Sun, Wuyuan Zhang and Bo Yuan

ChemCatChem, 2023, 15
DOI: 10.1002/cctc.202201621