Addressing misconceptions in dithiocarbamate chemistry

David Pugh and Graeme Hogarth

Dalton Trans., 2025, 54, 11464
DOI: 10.1039/D5DT01085C

Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases

Seppo Parkkila, Daniela Vullo, Alfonso Maresca, Fabrizio Carta, Andrea Scozzafava and Claudiu T. Supuran

Chem. Commun., 2012, 48, 3551
DOI: 10.1039/c2cc30359k

The crystal structures of 2-(4-benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide in complex with human carbonic anhydrase II and VII provide insights into selective CA inhibitor development

Katia D’Ambrosio, Anna Di Fiore, Martina Buonanno, Shikha Kumari, Manisha Tiwari, Claudiu T. Supuran, Chandra Bhushan Mishra, Simona Maria Monti and Giuseppina De Simone

New J. Chem., 2021, 45, 147
DOI: 10.1039/D0NJ03544K

Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors

Anna Di Fiore, Alessandro Vergara, Marco Caterino, Vincenzo Alterio, Simona M. Monti, Joanna Ombouma, Pascal Dumy, Daniela Vullo, Claudiu T. Supuran, Jean-Yves Winum and Giuseppina De Simone

Chem. Commun., 2015, 51, 11519
DOI: 10.1039/C5CC03711E

Polypharmacology of sulfonamides: pazopanib, a multitargeted receptor tyrosine kinase inhibitor in clinical use, potently inhibits several mammalian carbonic anhydrases

Jean-Yves Winum, Alfonso Maresca, Fabrizio Carta, Andrea Scozzafava and Claudiu T. Supuran

Chem. Commun., 2012, 48, 8177
DOI: 10.1039/c2cc33415a

Catechols: a new class of carbonic anhydrase inhibitors

Katia D'Ambrosio, Simone Carradori, Stefania Cesa, Andrea Angeli, Simona M. Monti, Claudiu T. Supuran and Giuseppina De Simone

Chem. Commun., 2020, 56, 13033
DOI: 10.1039/D0CC05172A

Diverse structural assemblies of U-shaped hydrazinyl-sulfonamides: experimental and theoretical analysis of non-covalent interactions stabilizing solid state conformations

Hina Andleeb, Imtiaz Khan, Antonio Franconetti, Muhammad Nawaz Tahir, Jim Simpson, Shahid Hameed and Antonio Frontera

CrystEngComm, 2019, 21, 1780
DOI: 10.1039/C8CE01917G

Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids

Kunal Nepali, Sahil Sharma, Manmohan Sharma, P.M.S. Bedi and K.L. Dhar

European Journal of Medicinal Chemistry, 2014, 77, 422
DOI: 10.1016/j.ejmech.2014.03.018

Design, Synthesis, and Biological Evaluation of 1,2,3-Triazole-linked triazino[5,6-b]indole-benzene sulfonamide Conjugates as Potent Carbonic Anhydrase I, II, IX, and XIII Inhibitors

Krishna Kartheek Chinchilli, Andrea Angeli, Pavitra S. Thacker, Laxman Naik Korra, Rashmita Biswas, Mohammed Arifuddin and Claudiu T. Supuran

Metabolites, 2020, 10, 200
DOI: 10.3390/metabo10050200

Anion inhibition studies of two new β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila

Isao Nishimori, Daniela Vullo, Tomoko Minakuchi, Andrea Scozzafava, Sameh M. Osman, Zeid AlOthman, Clemente Capasso and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry Letters, 2014, 24, 1127
DOI: 10.1016/j.bmcl.2013.12.124

Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents

Marco Bragagni, Murat Bozdag, Fabrizio Carta, Andrea Scozzafava, Cecilia Lanzi, Emanuela Masini, Paola Mura and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry, 2015, 23, 6223
DOI: 10.1016/j.bmc.2015.07.047

Natural Polyphenols Selectively Inhibit β‐Carbonic Anhydrase from the Dandruff‐Producing Fungus Malassezia globosa: Activity and Modeling Studies

Alessio Nocentini, Silvia Bua, Sonia Del Prete, Yeganeh Entezari Heravi, Ali A. Saboury, Anastasia Karioti, Anna Rita Bilia, Clemente Capasso, Paola Gratteri and Claudiu T. Supuran

ChemMedChem, 2018, 13, 816
DOI: 10.1002/cmdc.201800015

Dithiocarbamates effectively inhibit the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa

Daniela Vullo, Sonia Del Prete, Alessio Nocentini, Sameh M. Osman, Zeid AlOthman, Clemente Capasso, Murat Bozdag, Fabrizio Carta, Paola Gratteri and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry, 2017, 25, 1260
DOI: 10.1016/j.bmc.2016.12.040

Synthesis and biological evaluation of dithiocarbamate esters of parthenolide as potential anti-acute myelogenous leukaemia agents

Yahui Ding, Zhongjin Yang, Weizhi Ge, Beijia Kuang, Junqing Xu, Juan Yang, Yue Chen and Quan Zhang

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33, 1376
DOI: 10.1080/14756366.2018.1490734

Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action

Murat Bozdag, Fabrizio Carta, Daniela Vullo, Atilla Akdemir, Semra Isik, Cecilia Lanzi, Andrea Scozzafava, Emanuela Masini and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry, 2015, 23, 2368
DOI: 10.1016/j.bmc.2015.03.068

Mono- and di-thiocarbamate inhibition studies of the δ-carbonic anhydrase TweCAδ from the marine diatomThalassiosira weissflogii

Silvia Bua, Murat Bozdag, Sonia Del Prete, Fabrizio Carta, William A. Donald, Clemente Capasso and Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33, 707
DOI: 10.1080/14756366.2018.1450400

A Highlight on the Inhibition of Fungal Carbonic Anhydrases as Drug Targets for the Antifungal Armamentarium

Claudiu T. Supuran and Clemente Capasso

IJMS, 2021, 22, 4324
DOI: 10.3390/ijms22094324

Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae

Daniela Vullo, Semra Isik, Sonia Del Prete, Viviana De Luca, Vincenzo Carginale, Andrea Scozzafava, Claudiu T. Supuran and Clemente Capasso

Bioorganic & Medicinal Chemistry Letters, 2013, 23, 1636
DOI: 10.1016/j.bmcl.2013.01.084

Development of benzene and benzothiazole-sulfonamide analogues as selective inhibitors of the tumor-associated carbonic anhydrase IX

Shoaib Manzoor, Andrea Angeli, Susi Zara, Simone Carradori, Md Ataur Rahman, Md Kausar Raza, Claudiu T. Supuran and Nasimul Hoda

European Journal of Medicinal Chemistry, 2022, 243, 114793
DOI: 10.1016/j.ejmech.2022.114793

Synthesis of novel isoindoline-1,3-dione-based oximes and benzenesulfonamide hydrazones as selective inhibitors of the tumor-associated carbonic anhydrase IX

Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Mohamed A. Abu El-Enin, Abdulrahman A. Almehizia, Claudiu T. Supuran and Alessio Nocentini

Bioorganic Chemistry, 2018, 80, 706
DOI: 10.1016/j.bioorg.2018.07.027

Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata

Simona Maria Monti, Alfonso Maresca, Francesca Viparelli, Fabrizio Carta, Giuseppina De Simone, Fritz A. Mühlschlegel, Andrea Scozzafava and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry Letters, 2012, 22, 859
DOI: 10.1016/j.bmcl.2011.12.033

Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases

Kaspars Tars, Daniela Vullo, Andris Kazaks, Janis Leitans, Alons Lends, Aiga Grandane, Raivis Zalubovskis, Andrea Scozzafava and Claudiu T. Supuran

J. Med. Chem., 2013, 56, 293
DOI: 10.1021/jm301625s

Design, synthesis and pharmacological analysis of 5-[4′-(substituted-methyl)[1,1′-biphenyl]-2-yl]-1H-tetrazoles

Atulkumar Kamble, Ravindra Kamble, Suneel Dodamani, Sunil Jalalpure, Vijaykumar Rasal, Mahadev Kumbar, Shrinivas Joshi and Sheshagiri Dixit

Arch. Pharm. Res., 2017, 40, 444
DOI: 10.1007/s12272-017-0887-0

A Class of Sulfonamides with Strong Inhibitory Action against the α-Carbonic Anhydrase from Trypanosoma cruzi

Özlen Güzel-Akdemir, Atilla Akdemir, Peiwen Pan, Alane B. Vermelho, Seppo Parkkila, Andrea Scozzafava, Clemente Capasso and Claudiu T. Supuran

J. Med. Chem., 2013, 56, 5773
DOI: 10.1021/jm400418p

Discovery of novel heteroarylmethylcarbamodithioates as potent anticancer agents: Synthesis, structure-activity relationship analysis and biological evaluation

Ying-Bo Li, Xu Yan, Ri-Dong Li, Peng Liu, Shao-Qian Sun, Xin Wang, Jing-Rong Cui, De-Min Zhou, Ze-Mei Ge and Run-Tao Li

European Journal of Medicinal Chemistry, 2016, 112, 217
DOI: 10.1016/j.ejmech.2016.02.015

State of the Art on Carbonic Anhydrase Modulators for Biomedical Purposes

Murat Bozdag, Abdulmalik Saleh Alfawaz Altamimi, Daniela Vullo, Claudiu T. Supuran and Fabrizio Carta

CMC, 2019, 26, 2558
DOI: 10.2174/0929867325666180622120625

Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery

Claudiu T. Supuran

Expert Opinion on Drug Discovery, 2020, 15, 671
DOI: 10.1080/17460441.2020.1743676

Antiglaucoma carbonic anhydrase inhibitors: a patent review

Emanuela Masini, Fabrizio Carta, Andrea Scozzafava and Claudiu T Supuran

Expert Opinion on Therapeutic Patents, 2013, 23, 705
DOI: 10.1517/13543776.2013.794788

How many carbonic anhydrase inhibition mechanisms exist?

Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, 31, 345
DOI: 10.3109/14756366.2015.1122001

Sulphonamide inhibition studies of the β-carbonic anhydrase from the bacterial pathogenClostridium perfringens

Daniela Vullo, R. Siva Sai Kumar, Andrea Scozzafava, James G. Ferry and Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33, 31
DOI: 10.1080/14756366.2017.1388233

Xanthates and Trithiocarbonates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Effects in Vivo

Fabrizio Carta, Atilla Akdemir, Andrea Scozzafava, Emanuela Masini and Claudiu T. Supuran

J. Med. Chem., 2013, 56, 4691
DOI: 10.1021/jm400414j

A failed tentative to design a super carbonic anhydrase having the biochemical properties of the most thermostable CA (SspCA) and the fastest (SazCA) enzymes

Viviana De Luca, Sonia Del Prete, Vincenzo Carginale, Daniela Vullo, Claudiu T. Supuran and Clemente Capasso

Journal of Enzyme Inhibition and Medicinal Chemistry, 2015, 30, 989
DOI: 10.3109/14756366.2014.1002403

Dinuclear Monomeric and Macrocyclic Organotin Dithiocarbamates Derived from 1,10‐Diaza‐18‐crown‐6 and 4,4′‐Trimethylenedipiperidine

Norma A. Celis, Raul Villamil‐Ramos, Herbert Höpfl, Irán F. Hernández‐Ahuactzi, Mario Sánchez, Luis S. Zamudio‐Rivera and Victor Barba

Eur J Inorg Chem, 2013, 2013, 2912
DOI: 10.1002/ejic.201300134

5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: Solution and X-ray crystallographic studies

Janis Leitans, Agnese Sprudza, Muhammet Tanc, Igor Vozny, Raivis Zalubovskis, Kaspars Tars and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry, 2013, 21, 5130
DOI: 10.1016/j.bmc.2013.06.041

Structural variations in zinc(II) complexes with N,N-di(4-fluorobenzyl)dithiocarbamate and imines: New precursor for zinc sulfide nanoparticles

Pandurangan Selvaganapathi, Subbiah Thirumaran and Samuele Ciattini

Polyhedron, 2018, 149, 54
DOI: 10.1016/j.poly.2018.04.022

Synthesis of N′-phenyl-N-hydroxyureas and investigation of their inhibitory activities on human carbonic anhydrases

Murat Bozdag, Fabrizio Carta, Andrea Angeli, Sameh M. Osman, Fatmah A.S. Alasmary, Zeid AlOthman and Claudiu T. Supuran

Bioorganic Chemistry, 2018, 78, 1
DOI: 10.1016/j.bioorg.2018.02.029

Development of novel anilinoquinazoline-based carboxylic acids as non-classical carbonic anhydrase IX and XII inhibitors

Zainab M. Elsayed, Hadia Almahli, Alessio Nocentini, Andrea Ammara, Claudiu T. Supuran, Wagdy M. Eldehna and Sahar M. Abou-Seri

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38
DOI: 10.1080/14756366.2023.2191163

A new class of quinazoline-sulfonamides acting as efficient inhibitors against the α-carbonic anhydrase fromTrypanosoma cruzi

Ahmed M. Alafeefy, Mariangela Ceruso, Nabila A. Al-Jaber, Seppo Parkkila, Alane Beatriz Vermelho and Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2015, 30, 581
DOI: 10.3109/14756366.2014.956309

Thermodynamic, kinetic, and structural parameterization of human carbonic anhydrase interactions toward enhanced inhibitor design

Vaida Linkuvienė, Asta Zubrienė, Elena Manakova, Vytautas Petrauskas, Lina Baranauskienė, Audrius Zakšauskas, Alexey Smirnov, Saulius Gražulis, John E. Ladbury and Daumantas Matulis

Quart. Rev. Biophys., 2018, 51
DOI: 10.1017/S0033583518000082

Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor

Vincenzo Alterio, Davide Esposito, Simona Maria Monti, Claudiu T. Supuran and Giuseppina De Simone

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33, 151
DOI: 10.1080/14756366.2017.1405263

Synthesis of Thiazole-methylsulfonyl Derivatives, X-ray Study, and Investigation of Their Carbonic Anhydrase Activities: In Vitro and In Silico Potentials

Zahra Maryam, Ayşen Işık, Emine Rana Bağcı, Maksut Yıldız, Hakan Ünver, Ümit M. Kocyigit, Burak Kırılmaz, Ismail Celik, Ulviye Acar Çevik, Yusuf Özkay and Zafer Asım Kaplancıklı

ACS Omega, 2025, 10, 13583
DOI: 10.1021/acsomega.5c00509

Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds

Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Rezk R. Ayyad, Mariangela Ceruso and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry, 2016, 24, 20
DOI: 10.1016/j.bmc.2015.11.034

Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum —The η-carbonic anhydrases

Sonia Del Prete, Daniela Vullo, Gillian M. Fisher, Katherine T. Andrews, Sally-Ann Poulsen, Clemente Capasso and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry Letters, 2014, 24, 4389
DOI: 10.1016/j.bmcl.2014.08.015

Preparation of in-situ grown carbon nanotubes via dithiocarbamate in composites with excellent microstructure and mechanical performance

Shengjie Guan, Zhengxiang Zhong, Jun Li, Yaoyuan Xu, Lei Ding, Yudong Huang and Li Liu

Composites Science and Technology, 2021, 203, 108569
DOI: 10.1016/j.compscitech.2020.108569

N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibition

Alessio Nocentini, Daniela Vullo, Gianluca Bartolucci and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry, 2016, 24, 3612
DOI: 10.1016/j.bmc.2016.05.072

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

Andrea Angeli, Fabrizio Carta, Alessio Nocentini, Jean-Yves Winum, Raivis Zalubovskis, Atilla Akdemir, Valentina Onnis, Wagdy M. Eldehna, Clemente Capasso, Giuseppina De Simone, Simona Maria Monti, Simone Carradori, William A. Donald, Shoukat Dedhar and Claudiu T. Supuran

Metabolites, 2020, 10, 412
DOI: 10.3390/metabo10100412

Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors

Giuseppina De Simone, Vincenzo Alterio and Claudiu T Supuran

Expert Opinion on Drug Discovery, 2013, 8, 793
DOI: 10.1517/17460441.2013.795145

The revival of dithiocarbamates: from pesticides to innovative medical treatments

Laurine Kaul, Regine Süss, Andrew Zannettino and Katharina Richter

iScience, 2021, 24, 102092
DOI: 10.1016/j.isci.2021.102092

Design and synthesis of novel 1,2,3-triazole-dithiocarbamate hybrids as potential anticancer agents

Ying-Chao Duan, Yong-Cheng Ma, En Zhang, Xiao-Jing Shi, Meng-Meng Wang, Xian-Wei Ye and Hong-Min Liu

European Journal of Medicinal Chemistry, 2013, 62, 11
DOI: 10.1016/j.ejmech.2012.12.046

Sulfonamide inhibition studies of the β carbonic anhydrase from Drosophila melanogaster

Leo Syrjänen, Seppo Parkkila, Andrea Scozzafava and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry Letters, 2014, 24, 2797
DOI: 10.1016/j.bmcl.2014.04.117

Bacterial, fungal and protozoan carbonic anhydrases as drug targets

Clemente Capasso and Claudiu T Supuran

Expert Opinion on Therapeutic Targets, 2015, 19, 1689
DOI: 10.1517/14728222.2015.1067685

4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki–Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies

Benedetta Cornelio, Marie Laronze-Cochard, Mariangela Ceruso, Marta Ferraroni, Graham A. Rance, Fabrizio Carta, Andrei N. Khlobystov, Antonella Fontana, Claudiu T. Supuran and Janos Sapi

J. Med. Chem., 2016, 59, 721
DOI: 10.1021/acs.jmedchem.5b01771

Anion inhibition studies of two α-carbonic anhydrases from Lotus japonicus, LjCAA1 and LjCAA2

Daniela Vullo, Emmanouil Flemetakis, Andrea Scozzafava, Clemente Capasso and Claudiu T. Supuran

Journal of Inorganic Biochemistry, 2014, 136, 67
DOI: 10.1016/j.jinorgbio.2014.03.014

Recent advances in the discovery of zinc-binding motifs for the development of carbonic anhydrase inhibitors

Jean-Yves Winum and Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2015, 30, 321
DOI: 10.3109/14756366.2014.913587

Synthesis, Characterization, Cytotoxicity and Detailed HSA Interaction of New Zinc(II) Complexes Containing Dithiocarbamate and Heterocyclic N-donor Ligands

Somaye Shahraki, Maryam Saeidifar, Fereshteh Shiri and Ameneh Heidari

Polycyclic Aromatic Compounds, 2019, 39, 220
DOI: 10.1080/10406638.2017.1302972

Molecular Docking and Anticonvulsant Activity of Newly Synthesized Quinazoline Derivatives

Hatem A. Abuelizz, Rabab El Dib, Mohamed Marzouk, El-Hassane Anouar, Yousreya A. Maklad, Hanan N. Attia and Rashad Al-Salahi

Molecules, 2017, 22, 1094
DOI: 10.3390/molecules22071094

Anion Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora

Daniela Vullo, Ronny Lehneck, William A. Donald, Stefanie Pöggeler and Claudiu T. Supuran

Metabolites, 2020, 10, 93
DOI: 10.3390/metabo10030093

Fast 62–92 % yield preparation of amino acid dithiocarbamates in green solvent at room temperature

Najmedin Azizi and Mahboobe Marimi

Environ Chem Lett, 2013, 11, 371
DOI: 10.1007/s10311-013-0417-3

Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties, diuretic, and anticonvulsant action

Jorge R. A. Diaz, Gerardo Enrique Camí, Malva Liu-González, Daniel R. Vega, Daniela Vullo, Américo Juárez, José C. Pedregosa and Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, 31, 1102
DOI: 10.3109/14756366.2015.1096270

Benzoselenoates: A novel class of carbonic anhydrase inhibitors

Damiano Tanini, Antonella Capperucci, Maria Locuoco, Marta Ferraroni, Gabriele Costantino, Andrea Angeli and Claudiu T. Supuran

Bioorganic Chemistry, 2022, 122, 105751
DOI: 10.1016/j.bioorg.2022.105751

Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells

Murat Bozdag, Marta Ferraroni, Carol Ward, Fabrizio Carta, Silvia Bua, Andrea Angeli, Simon P. Langdon, Ian H. Kunkler, Abdul-Malek S. Al-Tamimi and Claudiu T. Supuran

European Journal of Medicinal Chemistry, 2019, 182, 111600
DOI: 10.1016/j.ejmech.2019.111600

Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo

Fabrizio Carta, Mayank Aggarwal, Alfonso Maresca, Andrea Scozzafava, Robert McKenna, Emanuela Masini and Claudiu T. Supuran

J. Med. Chem., 2012, 55, 1721
DOI: 10.1021/jm300031j

Structural Insights on Carbonic Anhydrase Inhibitory Action, Isoform Selectivity, and Potency of Sulfonamides and Coumarins Incorporating Arylsulfonylureido Groups

Murat Bozdag, Marta Ferraroni, Fabrizio Carta, Daniela Vullo, Laura Lucarini, Elisabetta Orlandini, Armando Rossello, Elisa Nuti, Andrea Scozzafava, Emanuela Masini and Claudiu T. Supuran

J. Med. Chem., 2014, 57, 9152
DOI: 10.1021/jm501314c

Cloning, Characterization, and Sulfonamide and Thiol Inhibition Studies of an α-Carbonic Anhydrase from Trypanosoma cruzi, the Causative Agent of Chagas Disease

Peiwen Pan, Alane Beatriz Vermelho, Giseli Capaci Rodrigues, Andrea Scozzafava, Martti E. E. Tolvanen, Seppo Parkkila, Clemente Capasso and Claudiu T. Supuran

J. Med. Chem., 2013, 56, 1761
DOI: 10.1021/jm4000616

A Class of 4-Sulfamoylphenyl-ω-aminoalkyl Ethers with Effective Carbonic Anhydrase Inhibitory Action and Antiglaucoma Effects

Murat Bozdag, Melissa Pinard, Fabrizio Carta, Emanuela Masini, Andrea Scozzafava, Robert McKenna and Claudiu T. Supuran

J. Med. Chem., 2014, 57, 9673
DOI: 10.1021/jm501497m

Synthesis and evaluation of new benzodioxole-based dithiocarbamate derivatives as potential anticancer agents and hCA-I and hCA-II inhibitors

Mehlika Dilek Altıntop, Belgin Sever, Gülşen Akalın Çiftçi, Kaan Kucukoglu, Ahmet Özdemir, Seyedeh Sara Soleimani, Hayrunnisa Nadaroglu and Zafer Asım Kaplancıklı

European Journal of Medicinal Chemistry, 2017, 125, 190
DOI: 10.1016/j.ejmech.2016.09.035

Microbial Carbonic Anhydrases in Biomimetic Carbon Sequestration for Mitigating Global Warming: Prospects and Perspectives

Himadri Bose and Tulasi Satyanarayana

Front. Microbiol., 2017, 8
DOI: 10.3389/fmicb.2017.01615

Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma

Daniela Vullo, Mariaconcetta Durante, Francesco Saverio Di Leva, Sandro Cosconati, Emanuela Masini, Andrea Scozzafava, Ettore Novellino, Claudiu T. Supuran and Fabrizio Carta

J. Med. Chem., 2016, 59, 5857
DOI: 10.1021/acs.jmedchem.6b00462

Advances in the structural annotation of human carbonic anhydrases and impact on future drug discovery

Alessio Nocentini and Claudiu T. Supuran

Expert Opinion on Drug Discovery, 2019, 14, 1175
DOI: 10.1080/17460441.2019.1651289

Structure-based drug discovery of carbonic anhydrase inhibitors

Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2012, 27, 759
DOI: 10.3109/14756366.2012.672983

Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins

Marta Ferraroni, Fabrizio Carta, Andrea Scozzafava and Claudiu T. Supuran

J. Med. Chem., 2016, 59, 462
DOI: 10.1021/acs.jmedchem.5b01720

Inhibition of the newly discovered β‑carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with inorganic anions and small molecules

Linda J. Urbański, Andrea Angeli, Vesa P. Hytönen, Anna Di Fiore, Seppo Parkkila, Giuseppina De Simone and Claudiu T. Supuran

Journal of Inorganic Biochemistry, 2020, 213, 111274
DOI: 10.1016/j.jinorgbio.2020.111274

Advances in structure-based drug discovery of carbonic anhydrase inhibitors

Claudiu T. Supuran

Expert Opinion on Drug Discovery, 2017, 12, 61
DOI: 10.1080/17460441.2017.1253677

Phosphorus versus Sulfur: Discovery of Benzenephosphonamidates as Versatile Sulfonamide‐Mimic Chemotypes Acting as Carbonic Anhydrase Inhibitors

Alessio Nocentini, Paola Gratteri and Claudiu T. Supuran

Chemistry A European J, 2019, 25, 1188
DOI: 10.1002/chem.201805039

Dithiocarbamates with potent inhibitory activity against theSaccharomyces cerevisiaeβ-carbonic anhydrase

Murat Bozdag, Fabrizio Carta, Daniela Vullo, Semra Isik, Zeid AlOthman, Sameh M. Osman, Andrea Scozzafava and Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, 31, 132
DOI: 10.3109/14756366.2015.1010529

Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity

Murat Bozdag, Ahmed Mahmoud Alafeefy, Abdul Malik Altamimi, Daniela Vullo, Fabrizio Carta and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry, 2017, 25, 677
DOI: 10.1016/j.bmc.2016.11.039

Discovery and optimization of novel dual dithiocarbamates as potent anticancer agents

Ri-Dong Li, Hui-Ling Wang, Ying-Bo Li, Zhong-Qing Wang, Xin Wang, Yi-Tao Wang, Ze-Mei Ge and Run-Tao Li

European Journal of Medicinal Chemistry, 2015, 93, 381
DOI: 10.1016/j.ejmech.2015.02.030

Benzenesulfonamides incorporating bulky aromatic/heterocyclic tails with potent carbonic anhydrase inhibitory activity

Murat Bozdag, Ahmed M. Alafeefy, Daniela Vullo, Fabrizio Carta, Nurcan Dedeoglu, Abdul-Malek S. Al-Tamimi, Nabila A. Al-Jaber, Andrea Scozzafava and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry, 2015, 23, 7751
DOI: 10.1016/j.bmc.2015.11.023

One-Pot Syntheses of PET-Based Plasticizer and Tetramethyl Thiuram Monosulfide (TMTS) as Vulcanization Accelerator for Rubber Production

Goran Milentijević, Milena Milošević, Svetomir Milojević, Smiljana Marković, Milica Rančić, Aleksandar Marinković and Milutin Milosavljević

Processes, 2023, 11, 1033
DOI: 10.3390/pr11041033

Synthesis and antitumor activity of tetrahydrocarbazole hybridized with dithioate derivatives

Hala Bakr El-Nassan

Journal of Enzyme Inhibition and Medicinal Chemistry, 2015, 30, 308
DOI: 10.3109/14756366.2014.922554

Sulfonamide-Derived Dithiocarbamate Gold(I) Complexes Induce the Apoptosis of Colon Cancer Cells by the Activation of Caspase 3 and Redox Imbalance

Javier Quero, José Carlos Royo, Beatrice Fodor, María Concepción Gimeno, Jesús Osada, María Jesús Rodríguez-Yoldi and Elena Cerrada

Biomedicines, 2022, 10, 1437
DOI: 10.3390/biomedicines10061437

Anti-proliferative activity of dithiocarbamate salts: Synthesis and in vitro study

Ghina’a Abu Deiab, Ali Hmedat, Mohammad El-khateeb, Lubna Tahtamouni, Lama Quraan, Mai AlSakhen, Nour Alabbas, Joman Aldhirat and Wamidh Talib

Chem. Pap., 2025, 79, 123
DOI: 10.1007/s11696-024-03730-w

Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action

Fabrizio Carta, Alexander Birkmann, Tamara Pfaff, Helmut Buschmann, Wilfried Schwab, Holger Zimmermann, Alfonso Maresca and Claudiu T. Supuran

J. Med. Chem., 2017, 60, 3154
DOI: 10.1021/acs.jmedchem.7b00183

Insights into the Antimicrobial Potential of Dithiocarbamate Anions and Metal-Based Species

Chien Ing Yeo, Edward R. T. Tiekink and Jactty Chew

Inorganics, 2021, 9, 48
DOI: 10.3390/inorganics9060048

7-Aryl-triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrase IX and XII

Alessio Nocentini, Mariangela Ceruso, Fabrizio Carta and Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, 31, 1226
DOI: 10.3109/14756366.2015.1115401

A new aspect to chaperone-like activity of bovine β-casein by protein–protein interactions study

Ahmad Sharifizadeh, Ali Akbar Saboury, Ali Akbar Moosavi-Movahedi, Maryam Salami and Reza Yousefi

International Journal of Biological Macromolecules, 2012, 51, 901
DOI: 10.1016/j.ijbiomac.2012.08.002

Selenocarbamates As a Prodrug‐Based Approach to Carbonic Anhydrase Inhibition

Andrea Angeli, Marta Ferraroni, Antonella Capperucci, Damiano Tanini, Gabriele Costantino and Claudiu T. Supuran

ChemMedChem, 2022, 17
DOI: 10.1002/cmdc.202200085

Antibacterial carbonic anhydrase inhibitors: an update on the recent literature

Claudiu T. Supuran and Clemente Capasso

Expert Opinion on Therapeutic Patents, 2020, 30, 963
DOI: 10.1080/13543776.2020.1811853

In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos

Ashok Aspatwar, Milka Hammaren, Mataleena Parikka, Seppo Parkkila, Fabrizio Carta, Murat Bozdag, Daniela Vullo and Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35, 65
DOI: 10.1080/14756366.2019.1683007

Tricyclic Sulfonamides Incorporating Benzothiopyrano[4,3-c]pyrazole and Pyridothiopyrano[4,3-c]pyrazole Effectively Inhibit α- and β-Carbonic Anhydrase: X-ray Crystallography and Solution Investigations on 15 Isoforms

Anna M. Marini, Alfonso Maresca, Mayank Aggarwal, Elisabetta Orlandini, Susanna Nencetti, Federico Da Settimo, Silvia Salerno, Francesca Simorini, Concettina La Motta, Sabrina Taliani, Elisa Nuti, Andrea Scozzafava, Robert McKenna, Armando Rossello and Claudiu T. Supuran

J. Med. Chem., 2012, 55, 9619
DOI: 10.1021/jm300878g

A class of carbonic anhydrase IX/XII – selective carboxylate inhibitors

Rakia Abd Alhameed, Emanuela Berrino, Zainab Almarhoon, Ayman El-Faham and Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35, 549
DOI: 10.1080/14756366.2020.1715388

Depsides from Origanum dictamnus and Satureja pilosa as selective inhibitors of carbonic anhydrases: Isolation, structure elucidation, X‐ray crystallography

Charikleia Paloukopoulou, Ogouschan Salim Ntagli, Luca Gherardi, Virginia Dourdouni, Glykeria Filippou, Vincenzo Alterio, Simone Giovannuzzi, Maria Luisa Massardi, Giuseppina De Simone, Roberto Ronca, Claudiu T. Supuran, Gennaro Pescitelli and Anastasia Karioti

Archiv der Pharmazie, 2025, 358
DOI: 10.1002/ardp.202400823

Synthesis, characterization and carbonic anhydrase I and II inhibitory evaluation of new sulfonamide derivatives bearing dithiocarbamate

Begüm Nurpelin Sağlık, Derya Osmaniye, Ulviye Acar Çevik, Serkan Levent, Betül Kaya Çavuşoğlu, Oya Büyükemir, Deniz Nezir, Abdullah Burak Karaduman, Yusuf Özkay, Ali Savaş Koparal, Şükrü Beydemir and Zafer Asım Kaplancıklı

European Journal of Medicinal Chemistry, 2020, 198, 112392
DOI: 10.1016/j.ejmech.2020.112392

N-aryl-N’-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties

Murat Bozdag, Giulio Poli, Andrea Angeli, Elena Lucarini, Tiziano Tuccinardi, Lorenzo Di Cesare Mannelli, Silvia Selleri, Carla Ghelardini, Jean-Yves Winum, Fabrizio Carta and Claudiu T. Supuran

Bioorganic Chemistry, 2019, 89, 103033
DOI: 10.1016/j.bioorg.2019.103033

A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation

Claudiu T. Supuran

Bioorganic & Medicinal Chemistry Letters, 2023, 93, 129411
DOI: 10.1016/j.bmcl.2023.129411

Carbonic Anhydrases: New Perspectives on Protein Functional Role and Inhibition in Helicobacter pylori

Cristina Campestre, Viviana De Luca, Simone Carradori, Rossella Grande, Vincenzo Carginale, Andrea Scaloni, Claudiu T. Supuran and Clemente Capasso

Front. Microbiol., 2021, 12
DOI: 10.3389/fmicb.2021.629163

Design, synthesis, and biological activity of novel dithiocarbamate‐methylsulfonyl hybrids as carbonic anhydrase inhibitors

Derya Osmaniye, Cüneyt Türkeş, Yeliz Demir, Yusuf Özkay, Şükrü Beydemir and Zafer A. Kaplancıklı

Archiv der Pharmazie, 2022, 355
DOI: 10.1002/ardp.202200132

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

Erik O. Pettersen, Peter Ebbesen, Roben G. Gieling, Kaye J. Williams, Ludwig Dubois, Philippe Lambin, Carol Ward, James Meehan, Ian H. Kunkler, Simon P. Langdon, Anne H. Ree, Kjersti Flatmark, Heidi Lyng, Maria J. Calzada, Luis del Peso, Manuel O. Landazuri, Agnes Görlach, Hubert Flamm, Jochen Kieninger, Gerald Urban, Andreas Weltin, Dean C. Singleton, Syed Haider, Francesca M. Buffa, Adrian L. Harris, Andrea Scozzafava, Claudiu T. Supuran, Isabella Moser, Gerhard Jobst, Morten Busk, Kasper Toustrup, Jens Overgaard, Jan Alsner, Jacques Pouyssegur, Johanna Chiche, Nathalie Mazure, Ibtissam Marchiq, Scott Parks, Afshan Ahmed, Margaret Ashcroft, Silvia Pastorekova, Yihai Cao, Kasper M. Rouschop, Brad G. Wouters, Marianne Koritzinsky, Hilda Mujcic and Dan Cojocari

Journal of Enzyme Inhibition and Medicinal Chemistry, 2015, 30, 689
DOI: 10.3109/14756366.2014.966704

N -Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII

Jekaterīna Ivanova, Fabrizio Carta, Daniela Vullo, Janis Leitans, Andris Kazaks, Kaspars Tars, Raivis Žalubovskis and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry, 2017, 25, 3583
DOI: 10.1016/j.bmc.2017.04.007

Novel approaches for designing drugs that interfere with pH regulation

Emanuela Berrino and Claudiu T. Supuran

Expert Opinion on Drug Discovery, 2019, 14, 231
DOI: 10.1080/17460441.2019.1567488

Computational Prediction of the Binding Pose of Metal-Binding Pharmacophores

Johannes Karges, Ryjul W. Stokes and Seth M. Cohen

ACS Med. Chem. Lett., 2022, 13, 428
DOI: 10.1021/acsmedchemlett.1c00584

Synthesis, characterization and carbonic anhydrase inhibitory activity of novel benzothiazole derivatives

F. Zehra Küçükbay, Nesrin Buğday, Hasan Küçükbay, Muhammet Tanc and Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, 31, 1221
DOI: 10.3109/14756366.2015.1114931

Modulating the Efficacy of Carbonic Anhydrase Inhibitors through Fluorine Substitution

Emanuela Berrino, Bastien Michelet, Agnès Martin‐Mingot, Fabrizio Carta, Claudiu T. Supuran and Sébastien Thibaudeau

Angew Chem Int Ed, 2021, 60, 23068
DOI: 10.1002/anie.202103211

In vitro anti-proliferative and anti-angiogenic activities of thalidomide dithiocarbamate analogs

Bishoy Y.A. El-Aarag, Tomonari Kasai, Magdy A.H. Zahran, Nadia I. Zakhary, Tsukasa Shigehiro, Sreeja C. Sekhar, Hussein S. Agwa, Akifumi Mizutani, Hiroshi Murakami, Hiroki Kakuta and Masaharu Seno

International Immunopharmacology, 2014, 21, 283
DOI: 10.1016/j.intimp.2014.05.007

Insights towards sulfonamide drug specificity in α-carbonic anhydrases

Mayank Aggarwal, Bhargav Kondeti and Robert McKenna

Bioorganic & Medicinal Chemistry, 2013, 21, 1526
DOI: 10.1016/j.bmc.2012.08.019

in silico Modeling of Curcumin Based Sulfonamides Inhibitors of the Human trans-Membrane Carbonic Anhydrase Isozyme, hCA IX by CoMSIA

Sarvesh Datta Dixit and Shalini Singh

ajomc, 2021, 6, 306
DOI: 10.14233/ajomc.2021.AJOMC-P354

Novel sulfonamide incorporating piperazine, aminoalcohol and 1,3,5-triazine structural motifs with carbonic anhydrase I, II and IX inhibitory action

Eva Havránková, Jozef Csöllei, Daniela Vullo, Vladimír Garaj, Pavel Pazdera and Claudiu T. Supuran

Bioorganic Chemistry, 2018, 77, 25
DOI: 10.1016/j.bioorg.2017.12.034

Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine–benzenesulfonamides acting as carbonic anhydrase inhibitors

Daniela Vullo, Claudiu T. Supuran, Andrea Scozzafava, Giuseppina De Simone, Simona Maria Monti, Vincenzo Alterio and Fabrizio Carta

Bioorganic & Medicinal Chemistry, 2016, 24, 3643
DOI: 10.1016/j.bmc.2016.06.005

Identification, crystallization, and first X-ray structure analyses of phenyl boronic acid-based inhibitors of human carbonic anhydrase-II

Saima Rasheed, Noor ul Huda, S. Zoë Fisher, Sven Falke, Sadaf Gul, Malik Shoaib Ahmad and M. Iqbal Choudhary

International Journal of Biological Macromolecules, 2024, 267, 131268
DOI: 10.1016/j.ijbiomac.2024.131268

Multicomponent Synthesis of S-Benzyl Dithiocarbamates from para-Quinone Methides and Their Biological Evaluation for the Treatment of Alzheimer’s Disease

Rapelly Venkatesh, Gauri Shankar, Aswathi C. Narayanan, Gyan Modi, Shahulhameed Sabiah and Jeyakumar Kandasamy

J. Org. Chem., 2022, 87, 6730
DOI: 10.1021/acs.joc.2c00423

Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster

Leo Syrjänen, Martti E.E. Tolvanen, Mika Hilvo, Daniela Vullo, Fabrizio Carta, Claudiu T. Supuran and Seppo Parkkila

Bioorganic & Medicinal Chemistry, 2013, 21, 1516
DOI: 10.1016/j.bmc.2012.08.046

More effective dithiocarbamate derivatives inhibiting carbonic anhydrases, generated by QSAR and computational design

Speranta Avram, Adina Luminita Milac, Fabrizio Carta and Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2013, 28, 350
DOI: 10.3109/14756366.2012.727410

Design, synthesis, and evaluation of novel coumarin-dithiocarbamate derivatives (IDs) as anti-colorectal cancer agents

Heping Zhu, Shilong Ying, Bingluo Zhou, Xinyang Hu, Xiao Liang, Wangyu Li, Dungai Wang, Hongchuan Jin and Yuanjiang Pan

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36, 593
DOI: 10.1080/14756366.2021.1875458

Inhibition of the β-carbonic anhydrase from the dandruff-producing fungusMalassezia globosawith monothiocarbamates

Alessio Nocentini, Daniela Vullo, Sonia Del Prete, Sameh M. Osman, Fatmah A.S. Alasmary, Zeid AlOthman, Clemente Capasso, Fabrizio Carta, Paola Gratteri and Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017, 32, 1064
DOI: 10.1080/14756366.2017.1355307

Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth Gyrodactylus salaris

Ashok Aspatwar, Harlan Barker, Heidi Aisala, Ksenia Zueva, Marianne Kuuslahti, Martti Tolvanen, Craig R. Primmer, Jaakko Lumme, Alessandro Bonardi, Amit Tripathi, Seppo Parkkila and Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37, 1577
DOI: 10.1080/14756366.2022.2080818

Poly(amidoamine) dendrimers show carbonic anhydrase inhibitory activity against α-, β-, γ- and η-class enzymes

Fabrizio Carta, Sameh M. Osman, Daniela Vullo, Zeid AlOthman, Sonia Del Prete, Clemente Capasso and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry, 2015, 23, 6794
DOI: 10.1016/j.bmc.2015.10.006

Sulfocoumarin‐, Coumarin‐, 4‐Sulfamoylphenyl‐Bearing Indazole‐3‐carboxamide Hybrids: Synthesis and Selective Inhibition of Tumor‐Associated Carbonic Anhydrase Isozymes IX and XII

Srinivas Angapelly, P. V. Sri Ramya, Andrea Angeli, Claudiu T. Supuran and Mohammed Arifuddin

ChemMedChem, 2017, 12, 1578
DOI: 10.1002/cmdc.201700446

Sulfonamides incorporating heteropolycyclic scaffolds show potent inhibitory action against carbonic anhydrase isoforms I, II, IX and XII

Elisabetta Barresi, Silvia Salerno, Anna Maria Marini, Sabrina Taliani, Concettina La Motta, Francesca Simorini, Federico Da Settimo, Daniela Vullo and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry, 2016, 24, 921
DOI: 10.1016/j.bmc.2016.01.018

Protonography, a technique applicable for the analysis ofη-carbonic anhydrase activity

Sonia Del Prete, Viviana De Luca, Claudiu T. Supuran and Clemente Capasso

Journal of Enzyme Inhibition and Medicinal Chemistry, 2015, 30, 920
DOI: 10.3109/14756366.2014.990963

Probing the Surface of Human Carbonic Anhydrase for Clues towards the Design of Isoform Specific Inhibitors

Melissa A. Pinard, Brian Mahon and Robert McKenna

BioMed Research International, 2015, 2015, 1
DOI: 10.1155/2015/453543

Inhibition of TRAF6-Ubc13 interaction in NFkB inflammatory pathway by analyzing the hotspot amino acid residues and protein–protein interactions using molecular docking simulations

Ria Biswas and Angshuman Bagchi

Computational Biology and Chemistry, 2017, 70, 116
DOI: 10.1016/j.compbiolchem.2017.08.014

New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII

Rita Meleddu, Simona Distinto, Filippo Cottiglia, Rossella Angius, Pierluigi Caboni, Andrea Angeli, Claudia Melis, Serenella Deplano, Stefano Alcaro, Francesco Ortuso, Claudiu T. Supuran and Elias Maccioni

ACS Med. Chem. Lett., 2020, 11, 852
DOI: 10.1021/acsmedchemlett.9b00644

6-Substituted Sulfocoumarins Are Selective Carbonic Anhdydrase IX and XII Inhibitors with Significant Cytotoxicity against Colorectal Cancer Cells

Aiga Grandane, Muhammet Tanc, Lorenzo Di Cesare Mannelli, Fabrizio Carta, Carla Ghelardini, Raivis Žalubovskis and Claudiu T. Supuran

J. Med. Chem., 2015, 58, 3975
DOI: 10.1021/acs.jmedchem.5b00523

Design, synthesis and antiproliferative activity studies of novel 1,2,3-triazole–dithiocarbamate–urea hybrids

Ying-Chao Duan, Yi-Chao Zheng, Xiao-Chen Li, Meng-Meng Wang, Xian-Wei Ye, Yuan-Yuan Guan, Gai-Zhi Liu, Jia-Xin Zheng and Hong-Min Liu

European Journal of Medicinal Chemistry, 2013, 64, 99
DOI: 10.1016/j.ejmech.2013.03.058

Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity

Cenzo Congiu, Valentina Onnis, Alessandro Deplano, Gianfranco Balboni, Nurcan Dedeoglu and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry Letters, 2015, 25, 3850
DOI: 10.1016/j.bmcl.2015.07.060

Anion Inhibition Studies of the Beta-Carbonic Anhydrase from Escherichia coli

Sonia Del Prete, Viviana De Luca, Alessio Nocentini, Andrea Scaloni, Margaret D. Mastrolorenzo, Claudiu T. Supuran and Clemente Capasso

Molecules, 2020, 25, 2564
DOI: 10.3390/molecules25112564

Modulating the Efficacy of Carbonic Anhydrase Inhibitors through Fluorine Substitution

Emanuela Berrino, Bastien Michelet, Agnès Martin‐Mingot, Fabrizio Carta, Claudiu T. Supuran and Sébastien Thibaudeau

Angewandte Chemie, 2021, 133, 23252
DOI: 10.1002/ange.202103211

Anion inhibition studies of the dandruff-producing fungus Malassezia globosa β-carbonic anhydrase MgCA

Sonia Del Prete, Daniela Vullo, Sameh M. Osman, Zeid AlOthman, Clemente Capasso and Claudiu T. Supuran

Bioorganic & Medicinal Chemistry Letters, 2015, 25, 5194
DOI: 10.1016/j.bmcl.2015.09.068

A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents

Jorge R. A. Diaz, Martín Fernández Baldo, Gustavo Echeverría, Héctor Baldoni, Daniela Vullo, Delia B. Soria, Claudiu T. Supuran and Gerardo E. Camí

Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, 31, 51
DOI: 10.1080/14756366.2016.1187143

Evaluation of 99mTc-sulfonamide and sulfocoumarin derivatives for imaging carbonic anhydrase IX expression

Misaki Nakai, Jihne Pan, Kuo-Shyan Lin, John R. Thompson, Alessio Nocentini, Claudiu T. Supuran, Yasuo Nakabayashi and Tim Storr

Journal of Inorganic Biochemistry, 2018, 185, 63
DOI: 10.1016/j.jinorgbio.2018.04.009

Inhibition of Carbonic Anhydrase from Trypanosoma Cruzi for the Management of Chagas Disease: An Underexplored Therapeutic Opportunity

Claudiu T Supuran

Future Med. Chem., 2016, 8, 311
DOI: 10.4155/fmc.15.185

Dithiocarbamates effectively inhibit the α-carbonic anhydrase from Neisseria gonorrhoeae

Simone Giovannuzzi, Nader S. Abutaleb, Chad S. Hewitt, Fabrizio Carta, Alessio Nocentini, Mohamed N. Seleem, Daniel P. Flaherty and Claudiu T. Supuran

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37, 1
DOI: 10.1080/14756366.2021.1988945

Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs–CAIs) for the Treatment of Rheumatoid Arthritis

Silvia Bua, Lorenzo Di Cesare Mannelli, Daniela Vullo, Carla Ghelardini, Gianluca Bartolucci, Andrea Scozzafava, Claudiu T. Supuran and Fabrizio Carta

J. Med. Chem., 2017, 60, 1159
DOI: 10.1021/acs.jmedchem.6b01607

Identification of Metal Dithiocarbamates as a Novel Class of Antileishmanial Agents

Dhiman Sankar Pal, Dipon Kumar Mondal and Rupak Datta

Antimicrob Agents Chemother, 2015, 59, 2144
DOI: 10.1128/AAC.05146-14

Novel 1,3,5-Triazinyl Aminobenzenesulfonamides Incorporating Aminoalcohol, Aminochalcone and Aminostilbene Structural Motifs as Potent Anti-VRE Agents, and Carbonic Anhydrases I, II, VII, IX, and XII Inhibitors

Eva Havránková, Vladimír Garaj, Šárka Mascaretti, Andrea Angeli, Zuzana Soldánová, Miroslav Kemka, Jozef Motyčka, Marie Brázdová, Jozef Csöllei, Josef Jampílek and Claudiu T. Supuran

IJMS, 2021, 23, 231
DOI: 10.3390/ijms23010231