Issue 23, 2022

Recent developments in enantioselective nickel(ii)-catalyzed conjugate additions

Abstract

This review highlights the recent developments in enantioselective nickel-catalyzed conjugate additions of various nucleophiles to numerous acceptor-activated olefins published since 2016. By the very fact of the lower costs of nickel catalysts in comparison with other transition metals, these reactions represent powerful and economic methodologies for the stereocontrolled formation of carbon–carbon and carbon-heteroatom bonds. When applied to initiate domino reactions, these processes allowed a direct access to a variety of complex and functionalized chiral molecules.

Graphical abstract: Recent developments in enantioselective nickel(ii)-catalyzed conjugate additions

Article information

Article type
Review Article
Submitted
01 juil. 2022
Accepted
23 oct. 2022
First published
24 oct. 2022

Org. Chem. Front., 2022,9, 6717-6748

Recent developments in enantioselective nickel(II)-catalyzed conjugate additions

H. Pellissier, Org. Chem. Front., 2022, 9, 6717 DOI: 10.1039/D2QO01047J

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