Issue 98, 2021

Contrasteric coupling of allenes and tetrahydroisoquinolines by iron-catalysed allenic C(sp2)–H functionalisation

Abstract

An iron-catalysed C–H functionalisation of simple monosubstituted allenes for the synthesis of 1-tetrahydroisoquinolinyl 1,1-disubstituted allenes is reported. This transformation represents the first example of a direct conversion of allenic C–H bonds to C–C bonds through cross dehydrogenative coupling. The optimized protocol features broad scope and employs mild, functional group tolerant conditions.

Graphical abstract: Contrasteric coupling of allenes and tetrahydroisoquinolines by iron-catalysed allenic C(sp2)–H functionalisation

Supplementary files

Article information

Article type
Communication
Submitted
22 oct. 2021
Accepted
18 nov. 2021
First published
24 nov. 2021

Chem. Commun., 2021,57, 13329-13332

Contrasteric coupling of allenes and tetrahydroisoquinolines by iron-catalysed allenic C(sp2)–H functionalisation

Y. Xia, N. W. Wade, P. N. Palermo, Y. Wang and Y. Wang, Chem. Commun., 2021, 57, 13329 DOI: 10.1039/D1CC05949A

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