Issue 91, 2021

Room-temperature C–H bond alkynylation by merging cobalt and photocatalysts

Abstract

A new protocol is developed for the mono- and bis-ortho-C–H alkynylation of easily accessible benzamide derivatives using alkynyl bromides at room temperature by merging cobalt and photocatalysts. The diverse reactivity of various alkynyl bromides towards the C–H alkynylation and competing C–H/N–H bond annulation reactions has been demonstrated to give the corresponding products in good yields with excellent functional group tolerance.

Graphical abstract: Room-temperature C–H bond alkynylation by merging cobalt and photocatalysts

Supplementary files

Article information

Article type
Communication
Submitted
18 sept. 2021
Accepted
25 oct. 2021
First published
25 oct. 2021

Chem. Commun., 2021,57, 12167-12170

Room-temperature C–H bond alkynylation by merging cobalt and photocatalysts

R. Mandal, N. Barsu, B. Garai, A. Das, D. Perekalin and B. Sundararaju, Chem. Commun., 2021, 57, 12167 DOI: 10.1039/D1CC05263B

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