Issue 1, 2015

A redox-responsive drug delivery system based on RGD containing peptide-capped mesoporous silica nanoparticles

Abstract

In this paper, an intracellular glutathione (GSH) responsive mesoporous silica nanoparticle (MSN-S-S-RGD) was developed as a drug nanocarrier by immobilizing the gatekeeper (RGD containing peptide) onto MSNs using disulfide bonds. The antitumor drug, DOX was loaded onto the porous structure of the MSNs and the DOX@MSN-S-S-RGD system has been proved to be an effective nanocarrier. It was determined that most of the drug could be entrapped with only a slight leakage. After being accumulated in tumor cells via the receptor-mediated endocytosis, the surface peptide layer of DOX@MSN-S-S-RGD was removed to trigger the release of the entrapped drug to kill the tumor cell due to the cleavage of the disulfide bonds by intracellular GSH.

Graphical abstract: A redox-responsive drug delivery system based on RGD containing peptide-capped mesoporous silica nanoparticles

Supplementary files

Article information

Article type
Paper
Submitted
15 sept. 2014
Accepted
18 oct. 2014
First published
22 oct. 2014

J. Mater. Chem. B, 2015,3, 39-44

A redox-responsive drug delivery system based on RGD containing peptide-capped mesoporous silica nanoparticles

Z. Li, J. Hu, Q. Xu, S. Chen, H. Jia, Y. Sun, R. Zhuo and X. Zhang, J. Mater. Chem. B, 2015, 3, 39 DOI: 10.1039/C4TB01533A

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