Issue 73, 2024

Synthesis of triazole-fused tetracyclic spirooxindole derivatives via metal-free Huisgen cycloaddition

Abstract

We report an efficient, metal free method for synthesizing tetracyclic spirooxindole derivatives from N-protected isatins and propargyl bromide via Huisgen cycloaddition. This simple and practicle method provides access to spirooxindoles containing five-, six-, or seven-membered rings fused to a triazole ring.

Graphical abstract: Synthesis of triazole-fused tetracyclic spirooxindole derivatives via metal-free Huisgen cycloaddition

Supplementary files

Article information

Article type
Communication
Submitted
24 mai 2024
Accepted
26 juil. 2024
First published
06 août 2024

Chem. Commun., 2024,60, 10009-10012

Synthesis of triazole-fused tetracyclic spirooxindole derivatives via metal-free Huisgen cycloaddition

S. Maiti, N. Parui, J. Halder and J. Dash, Chem. Commun., 2024, 60, 10009 DOI: 10.1039/D4CC02534B

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