Themed collection Biomaterials Science Lectureship Winners
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Harnessing lipid nanoparticles for efficient CRISPR delivery
Lipid-based nanomaterials have shown to mediate specific and effective CRISPR delivery in vivo for the treatment of various diseases, including cancers, genetic disorders and infectious diseases.
Biomater. Sci., 2021,9, 6001-6011
https://doi.org/10.1039/D1BM00537E
Engineering DNA scaffolds for delivery of anticancer therapeutics
DNA scaffolds with programmability in size, shape and surface chemistry have been engineered for the delivery of various anticancer therapeutics.
Biomater. Sci., 2015,3, 1018-1024
https://doi.org/10.1039/C4BM00459K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Hydrogel scaffolds as in vitro models to study fibroblast activation in wound healing and disease
Hydrogels offer controllable and well-defined in vitro platforms to study the role of the fibroblast in wound healing and fibrosis.
Biomater. Sci., 2014,2, 634-650
https://doi.org/10.1039/C3BM60319A
Recent progress in the development of near-infrared organic photothermal and photodynamic nanotherapeutics
Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have gained considerable attention due to their high tumor ablation efficiency, excellent spatial resolution and minimal side effects on normal tissue.
Biomater. Sci., 2018,6, 746-765
https://doi.org/10.1039/C7BM01210A
Supramolecular polymeric biomaterials
This review highlights how the dynamic chemistry of supramolecular polymeric hydrogels affords macroscopic properties implemented in emerging biomaterials.
Biomater. Sci., 2018,6, 10-37
https://doi.org/10.1039/C7BM00780A
Hierarchically structured hydrogels utilizing multifunctional assembling peptides for 3D cell culture
Synthetic multifunctional assembling peptides were designed to mimic the structure of collagen and allow independent control of hydrogel mechanical and biochemical properties through covalent crosslinking, enabling long-term in vitro 3D cell culture.
Biomater. Sci., 2020,8, 1256-1269
https://doi.org/10.1039/C9BM01894H
Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo
Delivery is the key challenge for siRNA based therapeutics.
Biomater. Sci., 2017,5, 38-40
https://doi.org/10.1039/C6BM00683C
MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition
Enzymatically-responsive bivalirudin polymers loaded in thermoresponsive hydrogels mediate localized therapeutic peptide delivery in spinal cord injuries. These materials respond to upregulated remodelling enzymes to release therapeutic peptide into injured tissue.
Biomater. Sci., 2015,3, 41-45
https://doi.org/10.1039/C4BM00259H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Subcutaneous delivery of an antibody against SARS-CoV-2 from a supramolecular hydrogel depot
Prolonged maintenance of therapeutically-relevant levels of broadly neutralizing antibodies (bnAbs) is necessary to enable passive immunization against infectious disease.
Biomater. Sci., 2023,11, 2065-2079
https://doi.org/10.1039/D2BM00819J
Development and optimization of an ocular hydrogel adhesive patch using definitive screening design (DSD)
Bioadhesive hydrogel patches based on chemically modified photocrosslinkable polymers with specific physicochemical properties for sealing and repair of ocular injuries.
Biomater. Sci., 2023,11, 1318-1334
https://doi.org/10.1039/D2BM01013E
Ciprofloxacin-loaded bioadhesive hydrogels for ocular applications
Micelles loaded in a photocrosslinkable gelatin based hydrogel as a non-invasive suture-free approach for corneal tissue regeneration after injury with infection.
Biomater. Sci., 2020,8, 5196-5209
https://doi.org/10.1039/D0BM00935K
Biomimetic proteoglycan nanoparticles for growth factor immobilization and delivery
Growth factor delivery is often challenging due to their short half-life, low stability, and rapid deactivation. Here, we engineered novel biomimetic proteoglycan nanocarriers for the immobilization and controlled release of growth factors.
Biomater. Sci., 2020,8, 1127-1136
https://doi.org/10.1039/C9BM00668K
Interpenetrating network gelatin methacryloyl (GelMA) and pectin-g-PCL hydrogels with tunable properties for tissue engineering
The design of new hydrogel-based biomaterials with tunable physical and biological properties is essential for the advancement of applications related to tissue engineering and regenerative medicine.
Biomater. Sci., 2018,6, 2938-2950
https://doi.org/10.1039/C8BM00474A
Designing well-defined photopolymerized synthetic matrices for three-dimensional culture and differentiation of induced pluripotent stem cells
In this work, we establish an approach for the three-dimensional (3D) culture and differentiation of induced pluripotent stem cells (iPSCs) within well-defined synthetic matrices using light-based chemistries of relevance for the study of both disease and regeneration.
Biomater. Sci., 2018,6, 1358-1370
https://doi.org/10.1039/C8BM00099A
In vitro and in vivo analysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogels
Engineering visible light crosslinked GelMA hydrogels with tunable physical properties.
Biomater. Sci., 2017,5, 2093-2105
https://doi.org/10.1039/C7BM00110J
Iodine-131-labeled, transferrin-capped polypyrrole nanoparticles for tumor-targeted synergistic photothermal-radioisotope therapy
Tumor-targeting nanoparticles based on transferrin-capped polypyrrole are fabricated by a one-step approach for combination cancer therapy with a remarkable synergistic therapeutic effect.
Biomater. Sci., 2017,5, 1828-1835
https://doi.org/10.1039/C7BM00409E
Effects of the poly(ethylene glycol) hydrogel crosslinking mechanism on protein release
Poly(ethylene glycol) hydrogel crosslinking mechanism has a differential effect on controlling protein release.
Biomater. Sci., 2016,4, 405-411
https://doi.org/10.1039/C5BM00256G
Reducible, dibromomaleimide-linked polymers for gene delivery
Reducible, dibromomaleimide-linked polycations exhibit reduced cytotoxicity compared to their non-degradable analogs and can be site-specifically functionalized.
Biomater. Sci., 2015,3, 112-120
https://doi.org/10.1039/C4BM00240G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Design of thiol–ene photoclick hydrogels using facile techniques for cell culture applications
Thiol–ene photoclick hydrogels with tunable biomechanical and biochemical properties for biological applications, including controlled cell culture, regenerative medicine, and drug delivery.
Biomater. Sci., 2014,2, 1612-1626
https://doi.org/10.1039/C4BM00187G
Controllably degradable β-sheet nanofibers and gels from self-assembling depsipeptides
Inserting an ester bond into self-assembling peptides generated controllably degradable nanofibers and hydrogels for 3D cell culture.
Biomater. Sci., 2013,1, 1037-1045
https://doi.org/10.1039/C3BM60161G
Comparative study of guanidine-based and lysine-based brush copolymers for plasmid delivery
Guanidinylated HPMA-co-oligolysine copolymers exhibit higher transfection efficiency to cultured cells than analogous lysine-based polymers for nucleic acid delivery.
Biomater. Sci., 2013,1, 736-744
https://doi.org/10.1039/C3BM60079C
Synthetic hydrogel platform for three-dimensional culture of embryonic stem cell-derived motor neurons
Presented is an engineered PEG hydrogel capable of supporting the viability and subsequent axon extension of encapsulated mouse embryonic stem cell-derived motor neurons in 3D.
Biomater. Sci., 2013,1, 460-469
https://doi.org/10.1039/C3BM00166K
About this collection
This collection highlights winners of the Biomaterials Science Lectureship. This annual award was established in 2014 to honour an early-stage career scientist who has made a significant contribution to the biomaterials field.
The 2023 Biomaterials Science Lectureship was awarded to Eric Appel (Stanford University)
Eric A. Appel is an Associate Professor of Materials Science & Engineering at Stanford University. He received his BS in Chemistry and MS in Polymer Science from California Polytechnic State University in San Luis Obispo, CA. Eric performed his MS thesis research with Dr Jim Hedrick and Dr Robert Miller at the IBM Almaden Research Center in San Jose, CA. He then obtained his PhD in Chemistry with Prof. Oren A. Scherman at the University of Cambridge. For his PhD work, Eric was the recipient of the Jon Weaver PhD prize from the Royal Society of Chemistry and a Graduate Student Award from the Materials Research Society. Upon graduating from Cambridge, he was awarded a National Research Service Award from the NIBIB and a Wellcome Trust Postdoctoral Fellowship to work with Prof. Robert Langer at MIT. Eric’s research at Stanford focuses on the development of biomaterials that can be used as tools to better understand fundamental biological processes and to engineer advanced healthcare solutions. His research has led to more than one hundred publications and 30 patents. While at Stanford, Eric has been awarded young faculty awards from the Hellman Foundation, American Diabetes Association, American Cancer Society, and PhRMA Foundation. He also recently received the IUPAC Hanwha-TotalEnergies Young Polymer Scientist Award in 2022 and the Society for Biomaterials Young Investigator Award in 2023.
This collection features articles published in Biomaterials Science from Eric Appel as well as the previous lectureship winners:
2022- Yizhou Dong, The Ohio State University, USA
2021- Nasim Annabi, University of California, USA
2020 – Kanyi Pu, Nanyang Technological University, Singapore
2019 - April Kloxin, University of Delaware, USA
2018 - Zhen Gu, University of North Carolina at Chapel Hill & North Carolina State University, USA
2017 - Zhuang Liu, Foochow University, China
2016 – Fan Yang, Stanford University, USA
2015 – Joel Collier, Duke University, USA
2014 – Suzie Pun, University of Washington, USA