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Challenges and opportunities for SERS in the infrared: materials and methods

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SARS-CoV-2 proteins monitored by long-range surface plasmon field-enhanced Raman scattering with hybrid bowtie nanoaperture arrays and nanocavities

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Investigation of mammalian cells expressing SARS-CoV-2 proteins by surface-enhanced Raman scattering and multivariate analysis

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Detection of SARS-CoV-2 N protein using AgNPs-modified aligned silicon nanowires BioSERS chip

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Insight into prognostics, diagnostics, and management strategies for SARS CoV-2

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Ultra-sensitive and fast optical detection of the spike protein of the SARS-CoV-2 using AgNPs/SiNWs nanohybrid based sensors

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Spectroscopic methods for COVID-19 detection and early diagnosis

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High power impulse magnetron sputtering (HiPIMS) prepared ultrathin gold film for plasmonic biosensor application

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Ag@Ni–NiO NW Core–Shell Nanowires: A Reliable Surface-Enhanced Raman Scattering (SERS) Substrate

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In-situ fabrication of 3D interior hotspots templated with a protein@Au core–shell structure for label-free and on-site SERS detection of viral diseases

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Ultrasensitive detection of SARS‐CoV‐2 antigen using surface‐enhanced Raman spectroscopy‐based lateral flow immunosensor

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Photonic Crystal Surface Mode Real-Time Imaging of RAD51 DNA Repair Protein Interaction with the ssDNA Substrate

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Label-Free Detection of the Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein at Physiologically Relevant Concentrations Using Surface-Enhanced Raman Spectroscopy

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A review of metal nanoparticle‐based surface‐enhanced Raman scattering substrates for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) detection

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SERS Detection of SARS‐CoV‐2 Spike Proteins and IgG Antibodies Using Metallic H‐type Nano‐Apertures

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Advances in nanobiosensors during the COVID-19 pandemic and future perspectives for the post-COVID era

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High-sensitivity and point-of-care detection of SARS-CoV-2 from nasal and throat swabs by magnetic SERS biosensor

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Innovative and versatile surface-enhanced Raman spectroscopy-inspired approaches for viral detection leading to clinical applications: A review

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Noise Management of Surface-Enhanced Raman Spectroscopy Using Two-Dimensional Materials

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ACS Sens., 2026
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Classification of Coronavirus Spike Proteins by Deep-Learning-Based Raman Spectroscopy and its Interpretative Analysis

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Plasmonic nanostructure-enhanced Raman scattering for detection of SARS-CoV-2 nucleocapsid protein and spike protein variants

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How Surface-Enhanced Raman Spectroscopy Could Contribute to Medical Diagnoses

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Diagnosing COVID-19 in nasopharyngeal secretion through Raman spectroscopy: a feasibility study

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The Label-Free Detection and Identification of SARS-CoV-2 Using Surface-Enhanced Raman Spectroscopy and Principal Component Analysis

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Biosensors, 2023, 13, 1014
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Analysis of SARS-CoV-2 spike RBD binding to ACE2 and its inhibition by fungal cohaerin C using surface enhanced Raman spectroscopy

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Current Trends in In Vitro Diagnostics Using Surface-Enhanced Raman Scattering in Translational Biomedical Research

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Biosensors, 2025, 15, 265
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Facile nanostructures via nanoimprinting for biomedical devices

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Detection of live SARS-CoV-2 virus and its variants by specially designed SERS-active substrates and spectroscopic analyses

Jaya Sitjar, Jiunn-Der Liao, Han Lee, Huey-Pin Tsai, Jen-Ren Wang, Chien-Hsiung Chen, Hao Wang and Bernard Haochih Liu

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Determination of the denaturation temperature of the Spike protein S1 of SARS-CoV-2 (2019 nCoV) by Raman spectroscopy

A.C. Hernández-Arteaga, H.J. Ojeda-Galván, M.C. Rodríguez-Aranda, J.F. Toro-Vázquez, J. Sánchez, M. José-Yacamán and H.R. Navarro-Contreras

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Extracting the SERS characteristic features of SARS-CoV-2 and using machine learning to quickly screen positive specimens among hospitalized patients

Jaya Sitjar, Huey-Pin Tsai, Han Lee, Chun-Wei Chang, Xin-Ni Wu and Jiunn-Der Liao

Talanta, 2026, 297, 128621
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Applications of Raman Spectroscopy in Pandemic Virology: A Comprehensive Review

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ACS Photonics, 2026
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State-of-the-art sensor technologies for tracking SARS-CoV-2 in contaminated food and packaging: Towards the future techniques of food safety assurance

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Label-free SERS method with size-matched selectivity for analytes of varying sizes

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Surfaces and Interfaces, 2024, 44, 103821
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Rapid, On-Site SARS-CoV-2 Variant Detection and Differentiation Using GLAD-Pristine Silver Nanorod Arrays and Machine Learning-Enhanced SERS

Sneha Senapati, Arvind Kaushik, Rajan, Aditya Singh, Ishaan Gupta, Rashmi Virkar, Smita S. Kulkarni, Vidya Arankalle and Jitendra Pratap Singh

ACS Omega, 2025, 10, 44978
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Enhancement in surface-enhanced Raman spectroscopy (SERS) substrates and the potential for diseases detection

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Ultrafast Detection of SARS-CoV-2 Spike Protein (S) and Receptor-Binding Domain (RBD) in Saliva Using Surface-Enhanced Raman Spectroscopy

Mohammed Ba Abdullah, Chahinez Dab, Mohammed Almalki, Abdullah Alnaim, Alaaedeen Abuzir and Chawki Awada

Applied Sciences, 2022, 12, 5039
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Simple, Fast and Convenient Magnetic Bead-Based Sample Preparation for Detecting Viruses via Raman-Spectroscopy

Susanne Pahlow, Marie Richard-Lacroix, Franziska Hornung, Nilay Köse-Vogel, Thomas G. Mayerhöfer, Julian Hniopek, Oleg Ryabchykov, Thomas Bocklitz, Karina Weber, Ralf Ehricht, Bettina Löffler, Stefanie Deinhardt-Emmer and Jürgen Popp

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Probing the mutation independent interaction of DNA probes with SARS-CoV-2 variants through a combination of surface-enhanced Raman scattering and machine learning

Parikshit Moitra, Ardalan Chaichi, Syed Mohammad Abid Hasan, Ketan Dighe, Maha Alafeef, Alisha Prasad, Manas Ranjan Gartia and Dipanjan Pan

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Spectroscopy: a versatile sensing tool for cost-effective and rapid detection of novel coronavirus (COVID-19)

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Integrative Metabolomic and Lipidomic Signatures of SARS-CoV-2 VOCs: Correlations with Hematological and Biochemical Markers

Budhadev Baral, Vaishali Saini, Siddharth Singh, Tarun Prakash Verma, Deb Kumar Rath, Jyotirmayee Bahinipati, Priyadarsini Panda, Shubhransu Patro, Namrata Misra, Manas Ranjan Behera, Kartik Muduli, Hamendra Singh Parmar, Ajay Kumar Meena, Rajesh Kumar, Sonali Agarwal, Soumya R. Mohapatra, Nirmal Kumar Mohakud and Hem Chandra Jha

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Synergistic surface-enhanced Raman scattering effect to distinguish live SARS-CoV-2 S pseudovirus

Jaya Sitjar, Hong-Zheng Xu, Chih-Yun Liu, Jen-Ren Wang, Jiunn-Der Liao, Huey-Pin Tsai, Han Lee, Bernard Haochih Liu and Chia-Wei Chang

Analytica Chimica Acta, 2022, 1193, 339406
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Functionalized cascaded tapered optical fiber sensor for simultaneous detection of dengue II E and SARS-CoV-2 S proteins

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Biosensors and Bioelectronics, 2025, 277, 117200
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In Situ Surface-Enhanced Raman Scattering Detection of a SARS-CoV-2 Biomarker Using Flexible and Transparent Polydimethylsiloxane Films with Embedded Au Nanoplates

Weiling Yue, Zhichao Xia, Zhiyou Zeng, Zhinan Chen, Ling Qiao, Panjie Li, Yi He and Xiaojun Luo

ACS Appl. Nano Mater., 2022, 5, 12897
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Characterization and discrimination of spike protein in SARS‐CoV‐2 virus‐like particles via surface‐enhanced Raman spectroscopy

Munevver Akdeniz, Zakarya Al‐Shaebi, Mine Altunbek, Canan Bayraktar, Alisan Kayabolen, Tugba Bagci‐Onder and Omer Aydin

Biotechnology Journal, 2024, 19
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Label-free and liquid state SERS detection of multi-scaled bioanalytes via light-induced pinpoint colloidal assembly

Seungyeon Han, Junhee Park, Sunghyun Moon, Seonghyeon Eom, Chang Min Jin, Seungmin Kim, Yong-Sang Ryu, Yeonho Choi, Jong Bum Lee and Inhee Choi

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Nanoparticle-functionalized 3D substrates for superior analytical performance in surface enhanced Raman spectroscopy

Nafsika Mouti, Nikolaos Kostoglou, Robert Obenaus-Emler and Christian Mitterer

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Identify the Virus-like Models for COVID-19 as Bio-Threats: Combining Phage Display, Spectral Detection and Algorithms Analysis

Yuting Wu, Zhiwei Liu, Sihan Mao, Bing Liu and Zhaoyang Tong

IJMS, 2023, 24, 3209
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3D interior hotspots embedded with viral lysates for rapid and label-free identification of infectious diseases

Soo Hyun Lee, Iris Baffour Ansah, Won-Chul Lee, Jun-Yeong Yang, ChaeWon Mun, Hyowon Jang, Sunjoo Kim, Sunghoon Jung, Min-Young Lee, Ho Sang Jung, Taejoon Kang, Seunghun Lee, Dong-Ho Kim and Sung-Gyu Park

Chemical Engineering Journal, 2023, 454, 140066
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Counter-propagating Gaussian beam enhanced Raman spectroscopy for rapid reagentless detection of respiratory pathogens in nasal swab samples

Gregory W. Auner, S. Kiran Koya, Changhe Huang, Charles J. Shanley, Micaela Trexler, Sally Yurgelevic, Jake DeMeulemeester, Krista Bui, Kristen Amyx-Sherer and Michelle A. Brusatori

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Plasmonic Nanostars: Systematic Review of their Synthesis and Applications

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Nanomaterial‐Based Optical Biosensors for SARS‐CoV‐2 Detection: A Retrospective of the Pandemic

Flavie Martin, Scott G. Harroun and Michel Meunier

Advanced Sensor Research, 2025, 4
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The Local Vibrational Mode Theory and Its Place in the Vibrational Spectroscopy Arena

Elfi Kraka, Mateus Quintano, Hunter W. La Force, Juliana J. Antonio and Marek Freindorf

J. Phys. Chem. A, 2022, 126, 8781
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Facile, Flexible, Fast’: Highly sensitive and Low-cost paper sensor for real time spike protein sensing with SERS

Krithikadevi Ramachandran, Kais Daoudi, Soumya columbus, Mounir Gaidi, Jannat Hammouche and Siva Chidambaram

Materials Science and Engineering: B, 2022, 286, 115984
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Recent development of surface-enhanced Raman scattering for biosensing

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J Nanobiotechnol, 2023, 21
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Machine Learning-Assisted 3D SERS Chip with Acoustic Enrichment for High-Accuracy Diagnosis of Respiratory Viruses and Emerging Pathogens

Yingjin Ma, Man-Chung Wong, Menglin Song, Pui Wang, Yuan Liu, Yifei Zhao, Honglin Chen, Juewen Liu and Jianhua Hao

ACS Sens., 2025, 10, 7886
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Focused ion beam-fabricated nanorod substrate for label-free surface-enhanced Raman spectroscopy and enabling dual virus detection

Han Lee, Jiunn-Der Liao, Huey-Pin Tsai, Hao Wang and Jaya Sitjar

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Raman Scattering-Based Biosensing: New Prospects and Opportunities

Kseniya V. Serebrennikova, Anna N. Berlina, Dmitriy V. Sotnikov, Anatoly V. Zherdev and Boris B. Dzantiev

Biosensors, 2021, 11, 512
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Molybdenum Disulfide-Assisted Spontaneous Formation of Multistacked Gold Nanoparticles for Deep Learning-Integrated Surface-Enhanced Raman Scattering

Wansun Kim, Jisang Han, Yoo Jin Kim, Hyerin Lee, Tae Gi Kim, Jae-Ho Shin, Dong-Ho Kim, Ho Sang Jung, Sang Woong Moon and Samjin Choi

ACS Nano, 2024, 18, 17557
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Nanomaterial-Based Biosensors for SARS-CoV-2 and Future Epidemics

Parsa Yari, Shuang Liang, Vinit Kumar Chugh, Bahareh Rezaei, Shahriar Mostufa, Venkatramana Divana Krishna, Renata Saha, Maxim C.-J. Cheeran, Jian-Ping Wang, Jenifer Gómez-Pastora and Kai Wu

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Molecular Understanding of the Surface-Enhanced Raman Spectroscopy Salivary Fingerprint in People after Sars-COV-2 Infection and in Vaccinated Subjects

Francesca Rodà, Alice Gualerzi, Silvia Picciolini, Luana Forleo, Valentina Mangolini, Roberta Mancuso, Simone Agostini, Rudy Alexander Rossetto, Paola Pierucci, Paolo Innocente Banfi and Marzia Bedoni

Chemosensors, 2024, 12, 136
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Fast screening of COVID-19 inpatient samples by integrating machine learning and label-free SERS methods

Jaya Sitjar, Huey-Pin Tsai, Han Lee, Chun-Wei Chang, Xin-Ni Wu and Jiunn-Der Liao

Analytica Chimica Acta, 2025, 1350, 343872
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Biofingerprint detection of corona virus using Raman spectroscopy: a novel approach

Muhammad Izzuddin Rumaling, Fuei Pien Chee, Abdullah Bade, Lucky Poh Wah Goh and Floressy Juhim

SN Appl. Sci., 2023, 5
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Label‐free laser spectroscopy for respiratory virus detection: A review

Yury V. Kistenev, Anubhab Das, Nirmal Mazumder, Olga P. Cherkasova, Anastasia I. Knyazkova, Alexander P. Shkurinov, Valery V. Tuchin and Igor K. Lednev

Journal of Biophotonics, 2022, 15
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3D Interior Hotspots Embedded with Viral Lysates for Rapid and Label-Free Identification of Infectious Diseases

Soo Hyun Lee, Iris Baffour Ansah, Won-Chul Lee, Jun-Yeong Yang, ChaeWon Mun, Hyowon Jang, Sunjoo Kim, Sunghoon Jung, Min-Young Lee, Ho Sang Jung, Taejoon Kang, Dong-Ho Kim, Seunghun Lee and Sung-Gyu Park

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Gold Nanorod-Based Surface-Enhanced Raman Spectroscopy for the Rapid and Selective Detection of Aconitine in Various Complex Matrices

Miao Qin, Mingwen Ma, Likun Deng, Guangkuo Tong and Cong Wang

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A biosensor based on magnetoelastic waves for detection of antibodies in human plasma for COVID-19 serodiagnosis

Wenderson R. F. Silva, Larissa C. P. Monteiro, Renato Lima Senra, Eduardo N. D. de Araújo, Rafael O. R. R. Cunha, Tiago A. de O. Mendes and Joaquim B. S. Mendes

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Recent advances of Au@Ag core–shell SERS‐based biosensors

Gul Awiaz, Jie Lin and Aiguo Wu

Exploration, 2023, 3
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Surface-enhanced Raman scattering-based immunoassay for severe acute respiratory syndrome coronavirus 2

Hyunjung Cha, Hyeran Kim, Younju Joung, Hyunju Kang, Jeong Moon, Hyowon Jang, Sohyun Park, Hyung-Jun Kwon, In-Chul Lee, Sunjoo Kim, Dongeun Yong, Sun-Woo Yoon, Sung-Gyu Park, Kyeonghye Guk, Eun-Kyung Lim, Hyun Gyu Park, Jaebum Choo, Juyeon Jung and Taejoon Kang

Biosensors and Bioelectronics, 2022, 202, 114008
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Recent Advances of Representative Optical Biosensors for Rapid and Sensitive Diagnostics of SARS-CoV-2

Meimei Xu, Yanyan Li, Chenglong Lin, Yusi Peng, Shuai Zhao, Xiao Yang and Yong Yang

Biosensors, 2022, 12, 862
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SARS-CoV-2 Virus-like Particles with Plasmonic Au Cores and S1-Spike Protein Coronas

Weronika Andrzejewska, Barbara Peplińska, Jagoda Litowczenko, Patryk Obstarczyk, Joanna Olesiak-Bańska, Stefan Jurga and Mikołaj Lewandowski

ACS Synth. Biol., 2023, 12, 2320
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Understanding the Excitation Wavelength Dependence and Thermal Stability of the SARS-CoV-2 Receptor-Binding Domain Using Surface-Enhanced Raman Scattering and Machine Learning

Kunyan Zhang, Ziyang Wang, He Liu, Néstor Perea-López, Jeewan C. Ranasinghe, George Bepete, Allen M. Minns, Randall M. Rossi, Scott E. Lindner, Sharon X. Huang, Mauricio Terrones and Shengxi Huang

ACS Photonics, 2022, 9, 2963
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Practical SERS substrates by spray coating of silver solutions for deep learning-assisted sensitive antigen identification

Furkan Sahin, Gamze Demirel Sahin, Ali Camdal, Ilkgul Akmayan, Tulin Ozbek, Serap Acar and Mustafa Serdar Onses

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2025, 707, 135828
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