Seabuckthorn polysaccharide ameliorates high-fat diet-induced obesity by gut microbiota-SCFAs-liver axis

Ying Lan, Qingyang Sun, Zhiyuan Ma, Jing Peng, Mengqi Zhang, Chi Wang, Xiaotian Zhang, Xianfang Yan, Lili Chang, Xinglin Hou, Ruixue Qiao, Aiziguli Mulati, Yuan Zhou, Qiang Zhang, Zhigang Liu and Xuebo Liu

Food Funct., 2022, 13, 2925
DOI: 10.1039/D1FO03147C

Aloe polysaccharides ameliorate obesity-associated cognitive dysfunction in high-fat diet-fed mice by targeting the gut microbiota and intestinal barrier integrity

Ling Mo, Jingjing Li, Hangsun Lu, Shaoda Lu, Henghui Fu, Bo Huang and Chaochao Zhao

Food Funct., 2024, 15, 8070
DOI: 10.1039/D4FO01844C

Neuroprotective Roles of Lauric Acid and Resveratrol: Shared Benefits in Neuroinflammation and Anxiety, Distinct Effects on Memory Enhancement

Betul Kisioglu, Esra Onal, Derya Karabulut, Ilyas Onbasilar and Asli Akyol

Food Science & Nutrition, 2024, 12, 9735
DOI: 10.1002/fsn3.4520

Nebulized seabuckthorn seed oil inhalation attenuates Alzheimer’s disease progression in APP/PS1 mice

Ruichen Ren, Gaorui Zhang, Junqing Ma, Yongze Zheng, Yuxuan Zhao, Yang Zhang and Lin Zhao

Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-89747-x

Diosmetin Ameliorates HFD-induced Cognitive Impairments via Inhibiting Metabolic Disorders, Mitochondrial Dysfunction and Neuroinflammation in Male SD Rats

Yiyuan Zhang, Chunyun Luo, Puxin Huang, Yahong Cheng, Yufang Ma, Jiefang Gao and Hong Ding

Mol Neurobiol, 2024, 61, 8069
DOI: 10.1007/s12035-024-04083-x

Research Advances of Neuroregulatory Effects of Dietary Polyphenols on Obesity Complications

Tingting Han, Limeng Wei, Wei Gu, Sen Zheng, Yiqun Du, Huifang Ge, Daxiang Li and Zhongwen Xie

Nutrients, 2026, 18, 1075
DOI: 10.3390/nu18071075

Identification of Natural Compounds Triggering MRGPRX2-Mediated Calcium Flux and Degranulation in RBL-2H3 Cells

Lihui Zhang, Jing Liu, Jian Zheng, Wenguang Jing, Wenjuan Zhang, Jia Chen, Xinyue Zhang, Xianlong Cheng and Feng Wei

Cells, 2026, 15, 287
DOI: 10.3390/cells15030287

Phenolic compounds in sea buckthorn (Hippophae rhamnoides L.) and their health-promoting activities: a review

Balwinder Singh, Somna Oberoi and Amritpal Kaur

International Journal of Food Science and Technology, 2024, 59, 6642
DOI: 10.1111/ijfs.17143

Phytonutrients and potential health benefits of California almonds: a comprehensive analysis of bioactives

Shunyang Wang, Clayton Bloszies, Kiana Lee, Bety Rostandy, Lisa Offringa, Hannah Josifek, Mary Beth Miranda, Swati Kalgaonkar and Ivana Blaženović

Food Chemistry, 2025, 494, 145120
DOI: 10.1016/j.foodchem.2025.145120

Recombinant hirudin prevents against nonalcoholic fatty liver disease by modulating PAR1/JAK2/STAT5/STAT3/CD36 pathway

Y.U. Xiaoyu, Yi Sun, Changyuan Wang, Yang Wang, Ru Hao and Huijun Sun

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2025, 1870, 159678
DOI: 10.1016/j.bbalip.2025.159678

Isorhamnetin alleviates fibromyalgia-like pain and mood deficits via monoaminergic, inflammatory, and TRPV1 pathways in mice

Abdelrahim Alqudah, Esam Qnais, Yousra Bsieso, Sireen Abdul Rahim Shilbayeh, Alaa A. A. Aljabali, Mohammad E. Rabeh, Ahmad M. Rabi and Rabaa Y. Athamneh

Mol Biol Rep, 2026, 53
DOI: 10.1007/s11033-026-11777-z

Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway

Xiao-rong Liu, Shuo-fu Li, Wen-ya Mei, Xiang-dan Liu and Ri-bao Zhou

Chin. J. Integr. Med., 2024, 30, 299
DOI: 10.1007/s11655-023-3753-6

Exploring the role of insulin resistance in bridging the metabolic syndrome and Alzheimer’s disease-a review of mechanistic studies

Shilei Wang, Yuqing Shi, Rui Xin, Hailan Kang, Huazhong Xiong and Jixiang Ren

Front. Endocrinol., 2025, 16
DOI: 10.3389/fendo.2025.1614006

Mediating role of inflammatory markers in the association between dietary isorhamnetin consumption and CKD risk

Chang Liu, Hanhan Kong, Guixia Li, Wujian Peng and Peijia Liu

Medicine, 2025, 104, e44703
DOI: 10.1097/MD.0000000000044703

Potential Role of Quercetin and Its Derivatives in Treatment of Cognitive Dysfunction Disorders

Liu-yi Song, Li Hu, Qing-he Zhou, Jian Lu, Shu-lei Zhang and Hong-mei Zhou

Chin. J. Integr. Med., 2026, 32, 353
DOI: 10.1007/s11655-025-3951-5

Evaluating the Clinical Impact of a Polyphenol-Rich Extract from Salicornia ramosissima on Patients with Transient Ischemic Attack and Minor Stroke

Ana M. Nájar, Cristina López Azcárate, Carmen Domínguez Ruiz, David Núñez-Jurado, Reyes de Torres, Reyes López, Miriam Camino-Moya, Eleonora Magni, Emilio Montero-Ramirez, Antonio Bocero, Álvaro Laviana, Teresa Busquier Cerdán, Antonio León, Carmen del Rio, Joan Montaner and Soledad Pérez-Sánchez

Nutrients, 2024, 16, 4307
DOI: 10.3390/nu16244307

Cinnamomum cassia Presl flavonoids prevent hyperglycemia-induced cognitive impairment via inhibiting of AGEs accumulation and oxidative stress

Hemei Li, Jinling Zhou, Sitong Liu, Xiuting Chen, Tiantian Qin, Guodong Huang, Peizhen Luo, Ying Hu and Xing Xia

Journal of Functional Foods, 2023, 100, 105374
DOI: 10.1016/j.jff.2022.105374

Network pharmacology analysis of the active ingredients of Corydalis hendersonii Hemsl. and their effects on eliminating neuroinflammation and improving motor functions in MPTP-intoxicated mice

Jun Wang, Qiu-Tong Liu, Dan-Yang Shen, Jin-Peng Bai, Yang Hu, Qin Huang, Hui-Jing Yu, Ning-Ning He, Xiao-Yan Qin and Rongfeng Lan

Journal of Ethnopharmacology, 2024, 318, 117009
DOI: 10.1016/j.jep.2023.117009

Sea buckthorn polysaccharide ameliorates high-fat diet induced mice neuroinflammation and synaptic dysfunction via regulating gut dysbiosis

Ying Lan, Zhiyuan Ma, Lili Chang, Jing Peng, Mengqi Zhang, Qingyang Sun, Ruixue Qiao, Xinglin Hou, Xuechao Ding, Qiang Zhang, Qiang Peng, Juane Dong and Xuebo Liu

International Journal of Biological Macromolecules, 2023, 236, 123797
DOI: 10.1016/j.ijbiomac.2023.123797

Beneficial effects of natural flavonoids on neuroinflammation

Yu Chen, Fu Peng, Ziwei Xing, Junren Chen, Cheng Peng and Dan Li

Front. Immunol., 2022, 13
DOI: 10.3389/fimmu.2022.1006434

Elucidation of the potential molecular mechanism of the active compounds of Bryophyllum pinnatum (L. f.) Oken against gastritis based on network pharmacology

Yue LIU, Yi LI, Yuan-Yuan YUAN, Zhao-Peng GENG, Juan-Ling LI, Min-Juan WANG and Jun-Li WANG

Chinese Journal of Analytical Chemistry, 2023, 51, 100193
DOI: 10.1016/j.cjac.2022.100193

Preparation of an isorhamnetin phospholipid complex for improving solubility and anti-hyperuricemia activity

Fengmao Zou, Honghui Zhao, Aijinxiu Ma, Danni Song, Xiangrong Zhang and Xu Zhao

Pharmaceutical Development and Technology, 2022, 27, 842
DOI: 10.1080/10837450.2022.2123510

Potential Use of Agave Genus in Neuroinflammation Management

Maribel Herrera-Ruiz, Enrique Jiménez-Ferrer, Manasés González-Cortazar, Alejandro Zamilpa, Alexandre Cardoso-Taketa, Martha Lucía Arenas-Ocampo, Antonio Ruperto Jiménez-Aparicio and Nayeli Monterrosas-Brisson

Plants, 2022, 11, 2208
DOI: 10.3390/plants11172208

Fruits of Hippophaë rhamnoides in human leukocytes and Caco-2 cell monolayer models—A question about their preventive role in lipopolysaccharide leakage and cytokine secretion in endotoxemia

Anna K. Laskowska, Aleksandra Wilczak, Weronika Skowrońska, Piotr Michel, Matthias F. Melzig and Monika E. Czerwińska

Front. Pharmacol., 2022, 13
DOI: 10.3389/fphar.2022.981874

Isorhamnetin Ameliorates Non-Esterified Fatty Acid-Induced Apoptosis, Lipid Accumulation, and Oxidative Stress in Bovine Endometrial Epithelial Cells via Inhibiting the MAPK Signaling Pathway

Haimiao Lv, Lijuan Liu, Wenna Zou, Ying Yang, Yuan Li, Shengji Yang, Aixin Liang and Liguo Yang

Antioxidants, 2025, 14, 156
DOI: 10.3390/antiox14020156

Sea buckthorn, its bioactive constituents, and mechanism of action: potential application in female reproduction

Michal Mihal, Shubhadeep Roychoudhury, Alexander V. Sirotkin and Adriana Kolesarova

Front. Endocrinol., 2023, 14
DOI: 10.3389/fendo.2023.1244300

Therapeutic targeting of Ras/Raf/MAPK pathway by natural products: A systematic and mechanistic approach for neurodegeneration

Mohammad Mehdi Gravandi, Sadaf Abdian, Maedeh Tahvilian, Amin Iranpanah, Seyed Zachariah Moradi, Sajad Fakhri and Javier Echeverría

Phytomedicine, 2023, 115, 154821
DOI: 10.1016/j.phymed.2023.154821

Swimming training and caffeine supplementation protects against metabolic syndrome–induced nuclear factor–κB activation and cognitive deficits in rats

Adson Souza-Pereira, Mariele da Silva Hernandez, Jozyê Milena da Silva Guerra, Bruno Henrique Nieswald, Matheus Chimelo Bianchini, Douglas Buchmann Godinho, Alexandre Seixas Nascimento, Robson Luiz Puntel, Luiz Fernando Freire Royes and Leonardo Magno Rambo

Nutrition Research, 2024, 122, 19
DOI: 10.1016/j.nutres.2023.11.002

Functional characterization of O-methyltransferases involved in biosynthesis of flavonoids in dwarf banana Musella lasiocarpa

Long Huang, Pirui Li, Junzhi Wu, Boya Feng, Mei Tian, Shu Xu, Wei Lyu, Xu Feng, Wanli Zhao and Yu Chen

M, 2025, 4, 0
DOI: 10.48130/mpb-0025-0004

Neuroprotective and Antidepressant Effects of Isorhamnetin: Mechanistic Evaluations in a Reserpine-Induced Mouse Model of Pain and Depression

Abdelrahim Alqudah, Esam Qnais, Yousra Bsieso, Omar Gammoh, Alaa A. A. Aljabali and Sireen Abdul Rahim Shilbayeh

Mol Neurobiol, 2025, 62, 15798
DOI: 10.1007/s12035-025-05244-2

Puerarin ameliorates nonalcoholic fatty liver in rats by regulating hepatic lipid accumulation, oxidative stress, and inflammation

Jingxuan Zhou, Nanhai Zhang, Adil Aldhahrani, Mohamed Mohamed Soliman, Liebing Zhang and Feng Zhou

Front. Immunol., 2022, 13
DOI: 10.3389/fimmu.2022.956688

고지방 및 고콜레스테롤 식이에 의한 비만유도에 따른 비만 마우스에서 Allium hookeri 열수 추출물의 인지기능 장애 개선 효과

하린 문 and 정미 윤

Korean J. Food Cook. Sci, 2025, 41, 192
DOI: 10.9724/kfcs.2025.41.3.192

In Vitro Comparative Analysis of the Effect and Structure-Based Influencing Factors of Flavonols on Lipid Accumulation

Beijun Ang, Tian Yang, Zhenyu Wang, Yong Cheng, Qiuming Chen, Zhaojun Wang, Maomao Zeng, Jie Chen and Zhiyong He

J. Agric. Food Chem., 2024, 72, 8237
DOI: 10.1021/acs.jafc.4c02159

Study on the pharmacokinetics and brain tissue distribution of eight anti-inflammatory active components in normal and neuroinflammatory rats orally administered with extract of Tinospora sinensis (Lour.) Merr. using the UPLC-MS/MS method

Liping Chen, Longhui Lu, Guoliang Xu, Zhihui Jiang, Qiujin Guo, Feijun Huang, Wenyan Yan, Hang Zhang, Yi Wu, Yongyan Xie and Liping Huang

Fitoterapia, 2025, 184, 106564
DOI: 10.1016/j.fitote.2025.106564

Neuroprotective effects of Yangming-Kaixin-Yizhi formula in Alzheimer’s disease: dual regulation of PI3K/Akt and p38 MAPK signaling via network pharmacology and experimental approaches

Jing Lei, Jiaming Li, Wei Wu, Rui Xiong, Yao Liu and Yong Tang

Metab Brain Dis, 2025, 40
DOI: 10.1007/s11011-025-01688-6

Alcoholic brain injury is a modifiable risk factor: natural active substance intervention promises to improve alcohol-induced cognitive impairment

Wenqi Wang, Yuhan Du, Xuewen Tong, Jiahua Liu, Mingming Lei, Liankui Wen, Yang He, Xinxin Meng and Xuanwei Xu

Front. Nutr., 2025, 12
DOI: 10.3389/fnut.2025.1578169

Isorhamnetin Alleviates Early-Life Stress-Induced Anxiety and Depression in Male Mice: Neuroinflammatory Modulation and Sirt1/NF-κB Signaling Insights

Esam Qnais, Omar Gammoh, Mohammad Alqudah, Manal Al-Bzour, Mohammed Wedyan, Abdelrahim Alqudah, Anwar M. Alnakhli, Sireen Abdul Rahim Shilbayeh, Alaa A. A. Aljabali and Taher Hatahet

Mol Neurobiol, 2026, 63
DOI: 10.1007/s12035-025-05483-3

Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration

Jialiu Zeng, Lenny Yi Tong Cheong and Chih Hung Lo

Front. Endocrinol., 2025, 15
DOI: 10.3389/fendo.2024.1456948

Multi-omics analysis provides new insights into molecular mechanisms for waterfowl fatty liver formation

Jingjing Qi, Junpeng Li, Yang Xi, Zhao Yang, Shihao Guo, Xu Han, Rui Wang, Liang Li, Lili Bai, Chunchun Han, Jiwen Wang and Hehe Liu

Poultry Science, 2025, 104, 105398
DOI: 10.1016/j.psj.2025.105398

Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) mimic neurotrophic functions in inducing neurite outgrowth in cultured neurons: Signaling via PI3K/Akt and ERK pathways

Chen-Xi Xia, Alex Xiong Gao, Tina Ting-Xia Dong and Karl Wah-Keung Tsim

Phytomedicine, 2023, 115, 154832
DOI: 10.1016/j.phymed.2023.154832

Sea buckthorn-nutritional composition, bioactivity, safety, and applications: A review

Wenting Yu, Yongqiang Du, Shanshan Li, Lun Wu, Xingyu Guo, Wen Qin, Xinlan Kuang, Xin Gao, Qiuhong Wang and Haixue Kuang

Journal of Food Composition and Analysis, 2024, 133, 106371
DOI: 10.1016/j.jfca.2024.106371

Review of Plant Extracts and Active Components: Mechanisms of Action for the Treatment of Obesity-Induced Cognitive Impairment

Ike de la Peña, Timothy Afable, Vina Rose Dahilig-Talan and Philip Cruz

Brain Sciences, 2023, 13, 929
DOI: 10.3390/brainsci13060929

Sea Buckthorn (Hippophae rhamnoides L.): Nutritional Significance, Phytochemistry, Molecular Mechanisms, Therapeutic Potential, and Emerging Applications in Food Systems

Nazish Javaid, Adnan Amjad, Ralf Weiskirchen, Asad Abbas, Shehnshah Zafar, Mohibullah Shah, Muhammad Sameem Javed, Khurram Afzal, Umrah Zafar and Muhammad Israr

Foods, 2026, 15, 1389
DOI: 10.3390/foods15081389

Natural products as pharmacological modulators of mitochondrial dysfunctions for the treatment of diabetes and its complications: An update since 2010

Qian-Ru Lin, Lian-Qun Jia, Ming Lei, Di Gao, Nan Zhang, Lei Sha, Xu-Han Liu and Yu-Dan Liu

Pharmacological Research, 2024, 200, 107054
DOI: 10.1016/j.phrs.2023.107054