Issue 57, 2023

Calcium-triggered DNA-mediated membrane fusion in synthetic cells

Abstract

In cells, membrane fusion is mediated by SNARE proteins, whose activities are calcium-dependent. While several non-native membrane fusion mechanisms have been demonstrated, few can respond to external stimuli. Here, we develop a calcium-triggered DNA-mediated membrane fusion strategy where fusion is regulated using surface-bound PEG chains that are cleavable by the calcium-activated protease calpain-1.

Graphical abstract: Calcium-triggered DNA-mediated membrane fusion in synthetic cells

Supplementary files

Article information

Article type
Communication
Submitted
05 mai 2023
Accepted
05 juin 2023
First published
07 juin 2023

Chem. Commun., 2023,59, 8806-8809

Author version available

Calcium-triggered DNA-mediated membrane fusion in synthetic cells

Y. Hsu, S. J. Chen, J. Bernal-Chanchavac, B. Sharma, H. Moghimianavval, N. Stephanopoulos and A. P. Liu, Chem. Commun., 2023, 59, 8806 DOI: 10.1039/D3CC02204H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements