Issue 38, 2022

Achieving regioselective materials binding using multidomain peptides

Abstract

The ability to integrate two disparate materials-binding domains into a single ligand to achieve regiospecific binding would be powerful to direct material assembly; however, this has proven challenging to achieve due to cross-materials binding. Accomplishing this goal might be achieved by harnessing the precision of biology to exploit the recognition between peptides and specific nanomaterials. Here, a designed bifunctional molecule termed Biomolecular Exfoliant and Assembly Motifs (BEAM) is introduced, featuring two different materials-binding peptide domains, one for graphene and one for hexagonal boron nitride (h-BN), at each end of the molecule, separated by a fatty acid spacer. The BEAM is demonstrated to bind strongly to both graphene and h-BN surfaces, and in each case the materials-binding peptide domain is shown to preferentially bind its target material. Critically, the two materials-binding domains exhibited limited cross-domain interaction. The BEAM design concept shows substantial potential to eventually guide self-organization of a range of materials in aqueous media.

Graphical abstract: Achieving regioselective materials binding using multidomain peptides

Supplementary files

Article information

Article type
Paper
Submitted
08 juin 2022
Accepted
30 août 2022
First published
08 sept. 2022

Nanoscale, 2022,14, 14113-14121

Author version available

Achieving regioselective materials binding using multidomain peptides

R. Jin, N. Brljak, R. Sangrigoli, T. R. Walsh and M. R. Knecht, Nanoscale, 2022, 14, 14113 DOI: 10.1039/D2NR03169H

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