Issue 17, 2021

Electrochemical synthesis of sulfonated benzothiophenes using 2-alkynylthioanisoles and sodium sulfinates

Abstract

Electrochemical sulfonylation/cyclization of 2-alkynylthioanisoles with sodium sulfinates was developed under catalyst-, external oxidant- and metal-free conditions. The electrosynthesis provides sustainable and efficient access to 3-sulfonated benzothiophenes with good substrate scope and functional group tolerance. This cascade radical process has been triggered through a sulfonyl radical addition to alkynes using sodium sulfinates under electrochemical conditions.

Graphical abstract: Electrochemical synthesis of sulfonated benzothiophenes using 2-alkynylthioanisoles and sodium sulfinates

Supplementary files

Article information

Article type
Paper
Submitted
15 janv. 2021
Accepted
22 mars 2021
First published
23 mars 2021

Org. Biomol. Chem., 2021,19, 3844-3849

Electrochemical synthesis of sulfonated benzothiophenes using 2-alkynylthioanisoles and sodium sulfinates

M. Zhang, Y. Sun, W. Wang, K. Chen, W. Yang and L. Wang, Org. Biomol. Chem., 2021, 19, 3844 DOI: 10.1039/D1OB00079A

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