Issue 41, 2021

Visible-light-mediated multicomponent reaction for secondary amine synthesis

Abstract

The widespread presence of secondary amines in agrochemicals, pharmaceuticals, natural products, and small-molecule biological probes has inspired efforts to streamline the synthesis of molecules with this functional group. Herein, we report an operationally simple, mild protocol for the synthesis of secondary amines by three-component alkylation reactions of imines (generated in situ by condensation of benzaldehydes and anilines) with unactivated alkyl iodides catalyzed by inexpensive and readily available Mn2(CO)10. This protocol, which is compatible with a wide array of sensitive functional groups and does not require a large excess of the alkylating reagent, is a versatile, flexible tool for the synthesis of secondary amines.

Graphical abstract: Visible-light-mediated multicomponent reaction for secondary amine synthesis

Supplementary files

Article information

Article type
Communication
Submitted
23 mars 2021
Accepted
13 avr. 2021
First published
14 avr. 2021

Chem. Commun., 2021,57, 5028-5031

Visible-light-mediated multicomponent reaction for secondary amine synthesis

X. Wang, B. Zhu, J. Dong, H. Tian, Y. Liu, H. Song and Q. Wang, Chem. Commun., 2021, 57, 5028 DOI: 10.1039/D1CC01560E

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