Issue 48, 2023

Engineered aptamers for molecular imaging

Abstract

Molecular imaging, including quantification and molecular interaction studies, plays a crucial role in visualizing and analysing molecular events occurring within cells or organisms, thus facilitating the understanding of biological processes. Moreover, molecular imaging offers promising applications for early disease diagnosis and therapeutic evaluation. Aptamers are oligonucleotides that can recognize targets with a high affinity and specificity by folding themselves into various three-dimensional structures, thus serving as ideal molecular recognition elements in molecular imaging. This review summarizes the commonly employed aptamers in molecular imaging and outlines the prevalent design approaches for their applications. Furthermore, it highlights the successful application of aptamers to a wide range of targets and imaging modalities. Finally, the review concludes with a forward-looking perspective on future advancements in aptamer-based molecular imaging.

Graphical abstract: Engineered aptamers for molecular imaging

Article information

Article type
Review Article
Submitted
31 juil. 2023
Accepted
07 nov. 2023
First published
21 nov. 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2023,14, 14039-14061

Engineered aptamers for molecular imaging

B. Lin, F. Xiao, J. Jiang, Z. Zhao and X. Zhou, Chem. Sci., 2023, 14, 14039 DOI: 10.1039/D3SC03989G

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