Issue 74, 2023

Highly chemoselective homologative assembly of the α-substituted methylsulfinamide motif from N-sulfinylamines

Abstract

α-Substituted methylsulfinamide are prepared through the homologation of electrophilic N-sulfinylamines with Li-CHXY reagents. The transformation takes place under full chemocontrol and exhibits good flexibility for preparing both N-aryl and N-alkyl analogues. Various sensitive functionalities can be accommodated on the starting materials, thus documenting a wide reaction scope.

Graphical abstract: Highly chemoselective homologative assembly of the α-substituted methylsulfinamide motif from N-sulfinylamines

Supplementary files

Article information

Article type
Communication
Submitted
12 juil. 2023
Accepted
21 août 2023
First published
21 août 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 11065-11068

Highly chemoselective homologative assembly of the α-substituted methylsulfinamide motif from N-sulfinylamines

M. Malik, R. Senatore, D. Castiglione, A. Roller-Prado and V. Pace, Chem. Commun., 2023, 59, 11065 DOI: 10.1039/D3CC03326K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements