Issue 51, 2023

Transition metal-catalysis in interrupted borrowing hydrogen strategy

Abstract

In recent times, the transition metal-catalyzed borrowing hydrogen (BH) and interrupted borrowing hydrogen (IBH) strategies have attracted much attention and represent atom- and step-economic processes to access diverse building blocks via various C–C and C–heteroatom bond-forming reactions. The advantages of these approaches include (i) use of feedstock chemicals, (ii) high atom economy, (iii) no pre-activation of the substrates, and (iv) producing water as the only by-product. In this context, several synthetic strategies have been developed in this regime for the past few decades. To the best of our knowledge, no review article describes the important concepts of interrupted borrowing hydrogen (IBH) reaction. This review article highlights the recent advances in the IBH strategy and its application in sustainable chemical synthesis, particularly C–C bond formation using methanol as a C1 source, synthesis of 3,3′-bisindolylmethanes (3,3′-BIMs), α-branched ketones/diketones, and regioselective alkylation of N-heterocycles.

Graphical abstract: Transition metal-catalysis in interrupted borrowing hydrogen strategy

Article information

Article type
Highlight
Submitted
28 mars 2023
Accepted
23 mai 2023
First published
24 mai 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 7847-7862

Transition metal-catalysis in interrupted borrowing hydrogen strategy

M. Nallagangula, M. Subaramanian, R. Kumar and E. Balaraman, Chem. Commun., 2023, 59, 7847 DOI: 10.1039/D3CC01517C

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