Issue 16, 2022

Tuning the immune system by nanoparticle–biomolecular corona

Abstract

Nanotechnology has a great potential to revolutionize the landscape of medicine, but an inadequate understanding of the nanomaterial-biological (nano–bio) interface hampers its ultimate clinical translation. Surface attachment of biomolecules provides a new biological identity of nanoparticles that plays a crucial role in vivo as it can activate the immune system triggering inflammatory responses, clearance from the body, and cellular toxicity. In this review, we summarize and critically analyze progress in understanding the relationship between the biological identity of nanoparticles and immune system activation. Accordingly, we discuss the implications of biomolecular corona on nanotoxicity, immune safety, and biocompatibility. We also highlight a perspective on engineering the biological identity of nanoparticles for modulating immunological responses.

Graphical abstract: Tuning the immune system by nanoparticle–biomolecular corona

Article information

Article type
Minireview
Submitted
06 mai 2022
Accepted
14 juil. 2022
First published
18 juil. 2022
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2022,4, 3300-3308

Tuning the immune system by nanoparticle–biomolecular corona

V. Palmieri and G. Caracciolo, Nanoscale Adv., 2022, 4, 3300 DOI: 10.1039/D2NA00290F

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