Issue 37, 2021

In vivo metal-catalyzed SeCT therapy by a proapoptotic peptide

Abstract

Selective cell tagging (SeCT) therapy is a strategy for labeling a targeted cell with certain chemical moieties via a catalytic chemical transformation in order to elicit a therapeutic effect. Herein, we report a cancer therapy based on targeted cell surface tagging with proapoptotic peptides (Ac-GGKLFG-X; X = reactive group) that induce apoptosis when attached to the cell surface. Using either Au-catalyzed amidation or Ru-catalyzed alkylation, these proapoptotic peptides showed excellent therapeutic effects both in vitro and in vivo. In particular, co-treatment with proapoptotic peptide and the carrier–Ru complex significantly and synergistically inhibited tumor growth and prolonged survival rate of tumor-bearing mice after only a single injection. This is the first report of Ru catalyst application in vivo, and this approach could be used in SeCT for cancer therapy.

Graphical abstract: In vivo metal-catalyzed SeCT therapy by a proapoptotic peptide

Supplementary files

Article information

Article type
Edge Article
Submitted
31 mars 2021
Accepted
16 août 2021
First published
02 sept. 2021
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2021,12, 12266-12273

In vivo metal-catalyzed SeCT therapy by a proapoptotic peptide

P. Ahmadi, K. Muguruma, T. Chang, S. Tamura, K. Tsubokura, Y. Egawa, T. Suzuki, N. Dohmae, Y. Nakao and K. Tanaka, Chem. Sci., 2021, 12, 12266 DOI: 10.1039/D1SC01784E

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