Issue 48, 2021

Synthesis of illudalic acid and analogous phosphatase inhibitors

Abstract

Developing an efficient, concise synthesis of the fungal natural product illudalic acid has been a long-standing challenge, made more pressing by the recent discovery that illudalic acid and analogs are selective phosphatase inhibitors. Syntheses of illudalic acid have become progressively more efficient over the decades yet remain strategically grounded in a 17-step synthesis reported in 1977. Here we validate a two-step process—convergent [4 + 2] benzannulation and one-pot coordinated functional group manipulations—for preparing the key trifunctional pharmacophore of illudalic acid. The modular building blocks are readily available in 2–3 steps, for a longest linear sequence (LLS) of 5 steps to illudalic acid from 3,3-dimethylcyclopentanone. A small collection of analogous indanes and tetralins featuring the same pharmacophore were prepared by a similar route. These compounds potently and selectively inhibit the human leukocyte common antigen-related (LAR) subfamily of protein tyrosine phosphatases (PTPs). Evidence supporting a postulated covalent ligation mechanism is provided herein.

Graphical abstract: Synthesis of illudalic acid and analogous phosphatase inhibitors

Supplementary files

Article information

Article type
Paper
Submitted
27 oct. 2021
Accepted
25 nov. 2021
First published
25 nov. 2021

Org. Biomol. Chem., 2021,19, 10596-10600

Synthesis of illudalic acid and analogous phosphatase inhibitors

H. F. Fulo, N. J. Rueb, R. Gaston, P. Batsomboon, K. T. Ahmed, A. M. Barrios and G. B. Dudley, Org. Biomol. Chem., 2021, 19, 10596 DOI: 10.1039/D1OB02106K

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