Issue 26, 2021

Peptide foldamer-based self-assembled nanostructures containing cyclic beta-amino acids

Abstract

Peptide soft materials belong to an emerging branch of materials sciences due to their growing importance as responsive materials in diagnostics, therapeutics, and biomedical applications. The diversity provided by easily modifiable peptide sequences can be further increased by introducing nonnatural amino acids such as cyclic β-amino acids, leading to the formation of foldamers. Moreover, it is possible to combine peptide chains with other polymers, aromatic compounds, etc. to create hybrids with completely new properties and applications. In this review, we focus on the cis/trans enantiomers of three cyclic β-amino acids: 2-aminocyclobutane-1-carboxylic acid (ACBC), 2-aminocyclopentane-1-carboxylic acid (ACPC) and 2-aminocyclohexane-1-carboxylic acid (ACHC). The peptides discussed here either contain exclusively β-amino acids or are α,β-peptides, and they undergo self-assembly by forming different interactions that lead to the creation of well-defined nanostructures.

Graphical abstract: Peptide foldamer-based self-assembled nanostructures containing cyclic beta-amino acids

Article information

Article type
Minireview
Submitted
09 avr. 2021
Accepted
04 juin 2021
First published
14 juin 2021
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2021,13, 11325-11333

Peptide foldamer-based self-assembled nanostructures containing cyclic beta-amino acids

M. Szefczyk, Nanoscale, 2021, 13, 11325 DOI: 10.1039/D1NR02220B

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