Issue 15, 2021

Upconversion nanoparticles modified by Cu2S for photothermal therapy along with real-time optical thermometry

Abstract

Highly effective photothermal conversion performance coupled with high resolution temperature detection in real time is urgently needed for photothermal therapy (PTT). Herein, ultra-small Cu2S nanoparticles (NPs) were designed to absorb on the surface of NaScF4: Yb3+/Er3+/Mn2+@NaScF4@SiO2 NPs to form a central-satellite system, in which the Cu2S NPs play the role of providing significant light-to-heat conversion ability and the Er3+ ions in the NaScF4: Yb3+/Er3+/Mn2+ cores act as a thermometric probe based on the fluorescence intensity ratio (FIR) technology operating in the biological windows. A wavelength of 915 nm is used instead of the conventional 980 nm excitation wavelength to eliminate the laser induced overheating effect for the bio-tissues, by which Yb3+ can also be effectively excited. The temperature resolution of the FIR-based optical thermometer is determined to be better than 0.08 K over the biophysical temperature range with a minimal value of 0.06 K at 298 K, perfectly satisfying the requirements of biomedicine. Under the radiation of 915 nm light, the Cu2S NPs exhibit remarkable light-to-heat conversion capacity, which is proved by photothermal ablation testing of E. coli. The results reveal the enormous potential of the present NPs for PTT integrated with real-time temperature sensing with high resolution.

Graphical abstract: Upconversion nanoparticles modified by Cu2S for photothermal therapy along with real-time optical thermometry

Supplementary files

Article information

Article type
Paper
Submitted
26 déc. 2020
Accepted
22 mars 2021
First published
23 mars 2021

Nanoscale, 2021,13, 7161-7168

Upconversion nanoparticles modified by Cu2S for photothermal therapy along with real-time optical thermometry

G. Xiang, Q. Xia, X. Liu, Y. Wang, S. Jiang, L. Li, X. Zhou, L. Ma, X. Wang and J. Zhang, Nanoscale, 2021, 13, 7161 DOI: 10.1039/D0NR09115D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements