Issue 18, 2021

Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years

Abstract

The eye is a complex structure with a variety of anatomical barriers and clearance mechanisms, so the provision of safe and effective ophthalmic drug delivery technology is a major challenge. In the past few decades, a number of reports have shown that nano-delivery platforms based on polymeric micelles are of great interest, because of their hydrophobic core that encapsulates lipid-soluble drugs and small size with high penetration, allowing long-term drug retention and posterior penetration in the eye. Furthermore, as an ocular delivery platform, polymeric micelles not only cover the single micellar drug delivery system formed by poloxamer, chitosan or other polymers, but also include composite drug delivery systems like micelle-encapsulated hydrogels and micelle-embedded contact lenses. In this review, a number of ophthalmic micelles that have emerged in the last three years will be systematically reviewed, with a summary of and discussion on their unique advantages or unique drug delivery performance. Last but not least, the current challenges of polymeric micelle formulations in potential clinical ophthalmic therapeutic applications will also be proposed, which might be helpful for future design of ocular drug delivery formulations.

Graphical abstract: Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years

Article information

Article type
Review Article
Submitted
30 juil. 2021
Accepted
08 août 2021
First published
10 août 2021
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2021,3, 5240-5254

Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years

Z. Li, M. Liu, L. Ke, L. Wang, C. Wu, C. Li, Z. Li and Y. Wu, Nanoscale Adv., 2021, 3, 5240 DOI: 10.1039/D1NA00596K

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements