Issue 42, 2020

Enhancing the photodynamic therapy efficacy of black phosphorus nanosheets by covalently grafting fullerene C60

Abstract

Few-layer black phosphorus (BP) nanosheets show potential application in biomedicine such as photodynamic therapy (PDT), and are therefore commonly used in anticancer therapy and nanomedicine due to being relatively less invasive. However, they suffer from low ambient stability and poor therapeutic efficacy. Herein, C60 was covalently grafted onto the edges of BP nanosheets, and the resultant BP-C60 hybrid was applied as a novel endocytosing photosensitizer, resulting in not only significantly enhanced PDT efficacy relative to that of the pristine BP nanosheets, but also drastically improved stability in a physiological environment, as confirmed by both in vitro and in vivo studies. Such improved stability was due to shielding effect of the stable hydrophobic C60 molecules. The enhanced PDT efficacy is interpreted from the photoinduced electron transfer from BP to C60, leading to the promoted generation of ˙OH radicals, acting as a reactive oxygen species (ROS) that is effective in killing tumor cells. Furthermore, the BP-C60 hybrid exhibited low systemic toxicity in the major organs of mice. The BP-C60 hybrid represents the first BP-fullerene hybrid nanomaterial fulfilling promoted ROS generation and consequently enhanced PDT efficacy.

Graphical abstract: Enhancing the photodynamic therapy efficacy of black phosphorus nanosheets by covalently grafting fullerene C60

Supplementary files

Article information

Article type
Edge Article
Submitted
16 juin 2020
Accepted
07 sept. 2020
First published
09 sept. 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 11435-11442

Enhancing the photodynamic therapy efficacy of black phosphorus nanosheets by covalently grafting fullerene C60

Y. Liu, D. Zhu, X. Zhu, G. Cai, J. Wu, M. Chen, P. Du, Y. Chen, W. Liu and S. Yang, Chem. Sci., 2020, 11, 11435 DOI: 10.1039/D0SC03349A

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