Issue 47, 2020

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

Abstract

The sudden ravaging outbreak of a novel coronavirus, or SARS-CoV-2, in terms of virulence, severity, and casualties has already overtaken previous versions of coronaviruses, like SARS CoV and MERS CoV. Originating from its epicenter in Wuhan, China, this mutated version of the influenza virus with its associated pandemic effects has engulfed the whole world with awful speed. In the midst of this bewildering situation, medical and scientific communities are on their toes to produce the potential vaccine-mediated eradication of this virus. Though the chances are really high, to date no such panacea has been reported. The time requirements for the onerous procedures of human trials for the successful clinical translation of any vaccine or potential therapeutics are also a major concern. In order to build some resistance against this massive pandemic, the repurposing of some earlier antiviral drugs has been done, along with the refurbishment of some immune-responsive alternative avenues, like monoclonal antibody mediated neutralization, interferon treatment, and plasma therapy. New drugs developed from the RBD domain of the virus spike protein and drugs targeting viral proteases are also undergoing further research and have shown potential from preliminary results. The sole purpose of this review article is to provide a brief collective overview of the recent status of therapeutics advances and approaches, and their current state of implementation for the management of COVID-19.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle

Article information

Article type
Review Article
Submitted
21 juin 2020
Accepted
09 juil. 2020
First published
28 juil. 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 28243-28266

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

G. Das, S. Ghosh, S. Garg, S. Ghosh, A. Jana, R. Samat, N. Mukherjee, R. Roy and S. Ghosh, RSC Adv., 2020, 10, 28243 DOI: 10.1039/D0RA05434H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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