Issue 7, 2019

Using automated glycan assembly (AGA) for the practical synthesis of heparan sulfate oligosaccharide precursors

Abstract

Herein we report synthesis of complex heparan sulfate oligosaccharide precursors by automated glycan assembly using disaccharide donor building blocks. Rapid access to a hexasaccharide was achieved through iterative solid phase glycosylations on a photolabile resin using Glyconeer™, an automated oligosaccharide synthesiser, followed by photochemical cleavage and glycan purification using simple flash column chromatography.

Graphical abstract: Using automated glycan assembly (AGA) for the practical synthesis of heparan sulfate oligosaccharide precursors

  • This article is part of the themed collection: New Talent

Supplementary files

Article information

Article type
Communication
Submitted
06 nov. 2018
Accepted
06 déc. 2018
First published
11 déc. 2018

Org. Biomol. Chem., 2019,17, 1817-1821

Using automated glycan assembly (AGA) for the practical synthesis of heparan sulfate oligosaccharide precursors

D. Budhadev, K. Saxby, J. Walton, G. Davies, P. C. Tyler, R. Schwörer and M. A. Fascione, Org. Biomol. Chem., 2019, 17, 1817 DOI: 10.1039/C8OB02756K

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