Issue 86, 2019

Visible light-mediated selective α-functionalization of 1,3-dicarbonyl compounds via disulfide induced aerobic oxidation

Abstract

A visible light-mediated α-functionalization of 1,3-dicarbonyl compounds with switchable selectivity induced by disulfide is disclosed. Upon irradiation with visible light, the metal- and base-free α-hydroxylation or α-hydroxymethylation reaction proceeded smoothly through a disulfide-catalyzed oxidation under mild conditions. The combination of a continuous-flow strategy could further improve the reaction efficiencies.

Graphical abstract: Visible light-mediated selective α-functionalization of 1,3-dicarbonyl compounds via disulfide induced aerobic oxidation

Supplementary files

Article information

Article type
Communication
Submitted
23 août 2019
Accepted
07 oct. 2019
First published
07 oct. 2019

Chem. Commun., 2019,55, 13008-13011

Visible light-mediated selective α-functionalization of 1,3-dicarbonyl compounds via disulfide induced aerobic oxidation

J. Zhao, F. Yang, Z. Yu, X. Tang, Y. Wu, C. Ma and Q. Meng, Chem. Commun., 2019, 55, 13008 DOI: 10.1039/C9CC06544J

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