Issue 77, 2019

Dual amplification ratiometric biosensor based on a DNA tetrahedron nanostructure and hybridization chain reaction for the ultrasensitive detection of microRNA-133a

Abstract

A novel ratiometric electrochemiluminescence (ECL)–electrochemical (EC) hybrid biosensor with a high accuracy and reproducibility was fabricated for the ultrasensitive detection of miRNA-133a. With the help of a DNA tetrahedron nanostructure and hybridization chain reaction dual amplification strategy, the detection limit of 12.17 aM for miRNA-133a was obtained.

Graphical abstract: Dual amplification ratiometric biosensor based on a DNA tetrahedron nanostructure and hybridization chain reaction for the ultrasensitive detection of microRNA-133a

Supplementary files

Article information

Article type
Communication
Submitted
19 juil. 2019
Accepted
30 août 2019
First published
30 août 2019

Chem. Commun., 2019,55, 11551-11554

Dual amplification ratiometric biosensor based on a DNA tetrahedron nanostructure and hybridization chain reaction for the ultrasensitive detection of microRNA-133a

L. Zhu, J. Ye, S. Wang, M. Yan, Q. Zhu, J. Huang and X. Yang, Chem. Commun., 2019, 55, 11551 DOI: 10.1039/C9CC05592D

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