Issue 13, 2019

NAG-targeting fluorescence based probe for precision diagnosis of kidney injury

Abstract

We report an enzyme-activated fluorescence based probe (NHPO) for the selective detection of N-acetyl-β-D-glucosaminidase (NAG) activity in a drug-induced kidney injury mice model and NAG level in crude human urine. We used NHPO to explore the biological functions of NAG and provide a reference for the prognosis and prediction of proximal renal tubular dysfunction associated with various kidney diseases.

Graphical abstract: NAG-targeting fluorescence based probe for precision diagnosis of kidney injury

Supplementary files

Article information

Article type
Communication
Submitted
31 déc. 2018
Accepted
14 janv. 2019
First published
14 janv. 2019
This article is Open Access
Creative Commons BY license

Chem. Commun., 2019,55, 1955-1958

NAG-targeting fluorescence based probe for precision diagnosis of kidney injury

F. Yan, X. Tian, Z. Luan, L. Feng, X. Ma and T. D. James, Chem. Commun., 2019, 55, 1955 DOI: 10.1039/C8CC10311A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements