Issue 10, 2017

Two decades of new drug discovery and development for Alzheimer's disease

Abstract

Alzheimer's disease is a progressive and irreversible neurodegenerative disease, associated with a decreased cognitive function and severe behavioral abnormalities. Due to its complex pathophysiological characteristics, complicated interactions with a large number of genes and proteins, there is still no effective drug treatment of the disease. Amyloid cascade aggregation of senile plaques and hyperphosphorylation of Tau protein to form neurofibrillary tangles are the main pathological features of Alzheimer's disease, other mechanisms, such as oxidative stress, lack of central cholinergic neurotransmitters, inflammatory reaction and toxic metal ions have also been involved. The purpose of this review is to briefly introduce the progress of the development of the therapeutic agents based on their main mechanisms of action.

Graphical abstract: Two decades of new drug discovery and development for Alzheimer's disease

Supplementary files

Article information

Article type
Review Article
Submitted
13 nov. 2016
Accepted
16 déc. 2016
First published
18 janv. 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 6046-6058

Two decades of new drug discovery and development for Alzheimer's disease

Z. Liu, A. Zhang, H. Sun, Y. Han, L. Kong and X. Wang, RSC Adv., 2017, 7, 6046 DOI: 10.1039/C6RA26737H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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